Yıl: 2021 Cilt: 19 Sayı: 1 Sayfa Aralığı: 36 - 45 Metin Dili: Türkçe DOI: 10.5336/anesthe.2020-80057 İndeks Tarihi: 12-05-2023

Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu

Öz:
Her yıl milyonlarca hasta, yoğun bakıma kabul edilmekte ve bunların 1/3’ü mekanik ventilatöre ihtiyaç duymaktadır. Durumu kritik derecede olan bu bireyler, hastalıklar, yaralanmalar, ventilatörler veya diğer tedaviler nedeniyle çeşitli sağlık sorunları yaşayabilmektedir. Bu tür sorunlar, yoğun bakım izlemi süresince tehlikeli süreç atlatılsa da her zaman tamamen ortadan kaldırılamayabilir ve bireyin taburculuk sonrası yaşamında da devam edebilir. Yoğun bakım sonrası sendromu; yoğun bakımda yatış sırasında ve taburcu olduktan sonra hastalarda or taya çıkan fiziksel, bilişsel ve mental bozukluklar ile uzun vadeli prog nozu ifade eder. Bu durum, ayrıca hastaların ailelerinde de mental olarak ortaya çıkabilmektedir. Yoğun bakımda kalan hastaların yarı sından fazlası, sendrom sonucu ortaya çıkan bozukluklardan en az bi rine sahip olmaktadır. Bu durum, kritik hastalık sonrası hayatta kalan bireylerin yaşamını ciddi olarak etkilemekte ve hastalar güçsüzlük, kas kaybı, dikkat eksikliği, hafıza kaybı, anksiyete, depresyon gibi birçok problemle karşı karşıya kalmaktadır. Bu tür olumsuzlukların önlenmesi için yoğun bakım sonrası sendromunun, multidisipliner ekip anlayışı çerçevesinde değerlendirilmesi ve önlemeye yönelik stratejilerin be nimsenmesi kritik rol oynamaktadır. Sendrom, günümüz yoğun bakım tıbbı ve alandaki sağlık profesyonelleri tarafından göz ardı edilmemesi ve önemsenmesi gereken hedefler içinde yerini almalıdır. Bu derlemede sendromun oluşumu, risk faktörleri ve önleme stratejileri tartışılarak, yoğun bakım alanında sıklıkla ihmal edilen bir konuya ışık tutmak ve sağlık profesyonellerinin farkındalığını artırmak amaçlanmaktadır
Anahtar Kelime:

The Neglected Consequences of Critical Illness Survivors: Post-Intensive Care Syndrome

Öz:
Millions of patients are admitted to intensive care every year, and one third of these require a mechanical ventilator. These critically ill individuals may experience various health problems due to illnesses, injuries, ventilators or other treatments. Even though the dangerous process is overcome during intensive care follow-up, such problems may not always be completely eliminated and may continue in the life of the individual after discharge. Post-intensive care syndrome refers to the long-term prognosis of patients as well as physical, cognitive and mental disorders that occur during hospitalization in intensive care and after discharge. This situation can also occur in families of patients. More than half of the patients staying in the intensive care unit have at least one of the disorders resulting from the syndrome. This situation seriously affects the lives of individuals who survive critical illness and patients face many problems such as weakness, muscle wasting, attention deficit, memory loss, anxiety and depression. Evaluation of post-intensive care syndrome within the framework of a multidisciplinary team understanding and adoption of prevention strategies play a critical role in preventing such adversities. The syndrome should be among the goals that should not be ignored and considered by today's intensive care medicine and health professionals in the field. In this review, the formation of the syndrome, risk factors and prevention strategies are discussed, aimed to shed light on this frequently neglected issue in the intensive care field and to increase the awareness of health professionals.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Bibliyografik
  • 1. Harvey MA, Davidson JE. Postintensive care syndrome: right care, right now…and later. Crit Care Med. 2016;44(2):381-5. [Crossref] [PubMed]
  • 2. Rawal G, Yadav S, Kumar R. Post-intensive care syndrome: an overview. J Transl Int Med. 2017;30;5(2):90-2. [Crossref] [PubMed] [PMC]
  • 3. Colbenson GA, Johnson A, Wilson ME. Post intensive care syndrome: impact, prevention, and management. Breathe (Sheff). 2019;15(2):98-101. [Crossref] [PubMed] [PMC]
  • 4. Inoue S, Hatakeyama J, Kondo Y, Hifumi T, Sakuramoto H, Kawasaki T, et al. Post-inten sive care syndrome: its pathophysiology, pre vention, and future directions. Acute Med Surg. 2019;25;6(3):233-46. [Crossref] [PubMed] [PMC]
  • 5. Needham DM, Davidson J, Cohen H, Hopkins RO, Weinert C, Wunsch H, et al. Improving long-term outcomes after discharge from in tensive care unit: report from a stakeholders' conference. Crit Care Med. 2012;40(2):502-9. [Crossref] [PubMed]
  • 6. Brown SM, Bose S, Banner-Goodspeed V, Beesley SJ, Dinglas VD, Hopkins RO, et al; Addressing Post Intensive Care Syndrome 01 (APICS-01) study team. Approaches to ad dressing post-ıntensive care syndrome among ıntensive care unit survivors. A narrative re view. Ann Am Thorac Soc. 2019;16(8):947-56. [Crossref] [PubMed]
  • 7. Davidson JE, Harvey MA. Patient and family post-ıntensive care syndrome. AACN Adv Crit Care. 2016;27(2):184-6. [Crossref] [PubMed]
  • 8. Wunsch H, Angus DC, Harrison DA, Collange O, Fowler R, Hoste EA, et al. Variation in crit ical care services across North America and Western Europe. Crit Care Med. 2008;36(10): 2787-93,e1-9. [Crossref] [PubMed]
  • 9. Kosinski S, Mohammad RA, Pitcher M, Haezebrouck E, Coe AB, Costa DK, et al. What Is post-intensive care syndrome (PICS)? Am J Respir Crit Care Med. 2020;15;201(8): P15-P6. [Crossref] [PubMed]
  • 10. Daniels LM, Johnson AB, Cornelius PJ, Bowron C, Lehnertz A, Moore M, et al. Im proving quality of life in patients at risk for post intensive care syndrome. Mayo Clin Proc Innov Qual Outcomes. 2018;2(4):359-69. [Crossref] [PubMed] [PMC]
  • 11. Pandharipande PP, Girard TD, Jackson JC, Morandi A, Thompson JL, Pun BT, et al; BRAIN-ICu Study Investigators. Long-term cognitive impairment after critical illness. N Engl J Med. 2013;3;369(14):1306-16. [Cross ref] [PubMed] [PMC]
  • 12. Maley JH, Brewster I, Mayoral I, Siruckova R, Adams S, McGraw KA, et al. Resilience in sur vivors of critical illness in the context of the survivors' experience and recovery. Ann Am Thorac Soc. 2016;13(8):1351-60. [Crossref] [PubMed] [PMC]
  • 13. Marra A, Pandharipande PP, Girard TD, Patel MB, Hughes CG, Jackson JC, et al. Co-oc currence of post-intensive care syndrome problems among 406 survivors of critical ill ness. Crit Care Med. 2018;46(9):1393-401. [Crossref] [PubMed] [PMC]
  • 14. Elliott D, Davidson JE, Harvey MA, Bemis Dougherty A, Hopkins RO, Iwashyna TJ, et al. Exploring the scope of post-intensive care syndrome therapy and care: engagement of non-critical care providers and survivors in a second stakeholders meeting. Crit Care Med. 2014;42(12):2518-26. [Crossref] [PubMed]
  • 15. Smith S, Rahman O. Post intensive care syn drome. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2020. p.1-31. (Baskı sayısı eklenmelidir.) [Link]
  • 16. Davidson JE, Jones C, Bienvenu OJ. Family response to critical illness: postintensive care syndrome-family. Crit Care Med. 2012;40(2):618-24. [Crossref] [PubMed]
  • 17. Schmidt M, Azoulay E. Having a loved one in the ICu: the forgotten family. Curr Opin Crit Care. 2012;18(5):540-7. [Crossref] [PubMed]
  • 18. Kress JP, Hall JB. ICu-acquired weakness and recovery from critical illness. N Engl J Med. 2014;24;370(17):1626-35. [Crossref] [PubMed]
  • 19. Latronico N, Bolton CF. Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis. Lancet Neurol. 2011;10(10):931-41. [Crossref] [PubMed]
  • 20. Farhan H, Moreno-Duarte I, Latronico N, Za fonte R, Eikermann M. Acquired muscle weak ness in the surgical ıntensive care unit: nosology, epidemiology, diagnosis, and pre vention. Anesthesiology. 2016;124(1):207-34. [Crossref] [PubMed]
  • 21. Stevens RD, Marshall SA, Cornblath DR, Hoke A, Needham DM, de Jonghe B, et al. A framework for diagnosing and classifying in tensive care unit-acquired weakness. Crit Care Med. 2009;37(10 Suppl):S299-308. [Crossref] [PubMed]
  • 22. De Jonghe B, Bastuji-Garin S, Sharshar T, Outin H, Brochard L. Does ICu-acquired pare sis lengthen weaning from mechanical venti lation? Intensive Care Med. 2004;30(6): 1117-21. [Crossref] [PubMed]
  • 23. Dinglas VD, Aronson Friedman L, Colantuoni E, Mendez-Tellez PA, Shanholtz CB, Ciesla ND, et al. Muscle weakness and 5-year sur vival in acute respiratory distress syndrome survivors. Crit Care Med. 2017;45(3):446-53. [Crossref] [PubMed] [PMC]
  • 24. Stevens RD, Dowdy DW, Michaels RK, Mendez-Tellez PA, Pronovost PJ, Needham DM. Neuromuscular dysfunction acquired in critical illness: a systematic review. Intensive Care Med. 2007;33(11):1876-91. [Crossref] [PubMed]
  • 25. Fan E, Dowdy DW, Colantuoni E, Mendez Tellez PA, Sevransky JE, Shanholtz C, et al. Physical complications in acute lung injury sur vivors: a two-year longitudinal prospective study. Crit Care Med. 2014;42(4):849-59. [Crossref] [PubMed] [PMC]
  • 26. Hermans G, Van Mechelen H, Clerckx B, Van hullebusch T, Mesotten D, Wilmer A, et al. Acute outcomes and 1-year mortality of inten sive care unit-acquired weakness. A cohort study and propensity-matched analysis. Am J Respir Crit Care Med. 2014;15;190(4):410-20. [Crossref] [PubMed]
  • 27. Griffiths J, Hatch RA, Bishop J, Morgan K, Jenkinson C, Cuthbertson BH, et al. An ex ploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study. Crit Care. 2013;28;17(3):R100. [Crossref] [PubMed] [PMC]
  • 28. Davidson JE, Harvey MA, Bemis-Dougherty A, Smith JM, Hopkins RO. Implementation of the pain, agitation, and delirium clinical prac tice guidelines and promoting patient mobility to prevent post-intensive care syndrome. Crit Care Med. 2013;41(9 Suppl 1):S136-45. [Crossref] [PubMed]
  • 29. Wolters AE, Slooter AJ, van der Kooi AW, van Dijk D. Cognitive impairment after inten sive care unit admission: a systematic review. Intensive Care Med. 2013;39(3):376-86. [Crossref] [PubMed]
  • 30. Hopkins RO, Suchyta MR, Snow GL, Jephson A, Weaver LK, Orme JF. Blood glucose dys regulation and cognitive outcome in ARDS survivors. Brain Inj. 2010;24(12):1478-84. [Crossref] [PubMed]
  • 31. Davydow DS, Zatzick D, Hough CL, Katon WJ. In-hospital acute stress symptoms are as sociated with impairment in cognition 1 year after intensive care unit admission. Ann Am Thorac Soc. 2013;10(5):450-7. [Crossref] [PubMed] [PMC]
  • 32. Jackson JC, Gordon SM, Ely EW, Burger C, Hopkins RO. Research issues in the evalua tion of cognitive impairment in intensive care unit survivors. Intensive Care Med. 2004;30(11):2009-16. [Crossref] [PubMed]
  • 33. Katz IR, Curyto KJ, TenHave T, Mossey J, Sands L, Kallan MJ. Validating the diagnosis of delirium and evaluating its association with deterioration over a one-year period. Am J Geriatr Psychiatry. 2001;9(2):148-59. [Cross ref] [PubMed]
  • 34. Needham DM, Dinglas VD, Morris PE, Jack son JC, Hough CL, Mendez-Tellez PA, et al, Hopkins RO; NIH NHLBI ARDS Network. Physical and cognitive performance of pa tients with acute lung injury 1 year after initial trophic versus full enteral feeding. EDEN trial follow-up. Am J Respir Crit Care Med. 2013;188(5):567-76. [Crossref] [PubMed] [PMC]
  • 35. Girard TD, Jackson JC, Pandharipande PP, Pun BT, Thompson JL, Shintani AK, et al. Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med. 2010;38(7):1513-20. [Crossref] [PubMed] [PMC]
  • 36. Iwashyna TJ, Ely EW, Smith DM, Langa KM. Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA. 2010;27;304(16):1787-94. [Crossref] [PubMed] [PMC]
  • 37. Gordon SM, Jackson JC, Ely EW, Burger C, Hopkins RO. Clinical identification of cognitive impairment in ICu survivors: insights for in tensivists. Intensive Care Med. 2004;30(11):1997-2008. [Crossref] [PubMed] [PMC]
  • 38. Sukantarat KT, Burgess PW, Williamson RC, Brett SJ. Prolonged cognitive dysfunction in survivors of critical illness. Anaesthesia. 2005;60(9):847-53. [Crossref] [PubMed]
  • 39. Jones C, Griffiths RD, Humphris G, Skirrow PM. Memory, delusions, and the development of acute posttraumatic stress disorder-related symptoms after intensive care. Crit Care Med. 2001;29(3):573-80. [Crossref] [PubMed]
  • 40. Davydow DS, Hough CL, Langa KM, Iwashyna TJ. Symptoms of depression in sur vivors of severe sepsis: a prospective cohort study of older Americans. Am J Geriatr Psy chiatry. 2013;21(9):887-97. [Crossref] [PubMed] [PMC]
  • 41. Davydow DS, Desai SV, Needham DM, Bien venu OJ. Psychiatric morbidity in survivors of the acute respiratory distress syndrome: a systematic review. Psychosom Med. 2008;70(4):512-9. [Crossref] [PubMed]
  • 42. Jackson JC, Obremskey W, Bauer R, Greevy R, Cotton BA, Anderson V, et al. Long-term cognitive, emotional, and functional outcomes in trauma intensive care unit survivors without intracranial hemorrhage. J Trauma. 2007;62(1):80-8. [Crossref] [PubMed]
  • 43. Dowdy DW, Dinglas V, Mendez-Tellez PA, Bi envenu OJ, Sevransky J, Dennison CR, et al. Intensive care unit hypoglycemia predicts de pression during early recovery from acute lung injury. Crit Care Med. 2008;36(10):2726-33. [Crossref] [PubMed] [PMC]
  • 44. Kress JP. Sedation and mobility: changing the paradigm. Crit Care Clin. 2013;29(1):67-75. [Crossref] [PubMed]
  • 45. Hopkins RO, Key CW, Suchyta MR, Weaver LK, Orme JF Jr. Risk factors for depression and anxiety in survivors of acute respiratory distress syndrome. Gen Hosp Psychiatry. 2010;32(2):147-55. [Crossref] [PubMed]
  • 46. Wunsch H, Christiansen CF, Johansen MB, Olsen M, Ali N, Angus DC, et al. Psychiatric diagnoses and psychoactive med ication use among nonsurgical critically ill patients receiving mechanical ventilation. JAMA. 2014;311(11):1133-42. [Crossref] [PubMed]
  • 47. Davydow DS, Gifford JM, Desai SV, Bienvenu OJ, Needham DM. Depression in general in tensive care unit survivors: a systematic re view. Intensive Care Med. 2009;35(5): 796-809. [Crossref] [PubMed]
  • 48. Davydow DS, Gifford JM, Desai SV, Needham DM, Bienvenu OJ. Posttraumatic stress disor der in general intensive care unit survivors: a systematic review. Gen Hosp Psychiatry. 2008;30(5):421-34. [Crossref] [PubMed] [PMC]
  • 49. Iwashyna TJ. Survivorship will be the defining challenge of critical care in the 21st century. Ann Intern Med. 2010;3;153(3):204-5. [Cross ref] [PubMed]
  • 50. Netzer G, Sullivan DR. Recognizing, naming, and measuring a family intensive care unit syndrome. Ann Am Thorac Soc. 2014;11(3): 435-41. [Crossref] [PubMed] [PMC]
  • 51. Jezierska N. Psychological reactions in family members of patients hospitalised in intensive care units. Anaesthesiol Intensive Ther. 2014;46(1):42-5. [Crossref] [PubMed]
  • 52. Sullivan DR, Liu X, Corwin DS, Verceles AC, McCurdy MT, Pate DA, et al. Learned help lessness among families and surrogate deci sion-makers of patients admitted to medical, surgical, and trauma ICus. Chest. 2012; 142(6):1440-6. [Crossref] [PubMed] [PMC]
  • 53. Wang S, Allen D, Perkins A, Monahan P, Khan S, Lasiter S, et al. Validation of a new clinical tool for post-intensive care syndrome. Am J Crit Care. 2019;28(1):10-8. [Crossref] [PubMed] [PMC]
  • 54. Fan E, Cheek F, Chlan L, Gosselink R, Hart N, Herridge MS, et al; ATS Committee on ICu acquired Weakness in Adults; American Tho racic Society. An official American Thoracic Society Clinical Practice guideline: the diag nosis of intensive care unit-acquired weak ness in adults. Am J Respir Crit Care Med. 2014;15;190(12):1437-46. [Crossref] [PubMed]
  • 55. Schweickert WD, Hall J. ICu-acquired weak ness. Chest. 2007;131(5):1541-9. [Crossref] [PubMed]
  • 56. Woon FL, Dunn CB, Hopkins RO. Predicting cognitive sequelae in survivors of critical ill ness with cognitive screening tests. Am J Respir Crit Care Med. 2012;15;186(4):333-40. [Crossref] [PubMed]
  • 57. Nasreddine ZS, Phillips NA, Bédirian V, Char bonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impair ment. J Am Geriatr Soc. 2005;53(4):695-9. Er ratum in: J Am Geriatr Soc. 2019;67(9):1991. [Crossref] [PubMed]
  • 58. Vlake JH, van Genderen ME, Schut A, Verkade M, Wils EJ, Gommers D, et al. Pa tients suffering from psychological impair ments following critical illness are in need of information. J Intensive Care. 2020;8(6):1-10. [Crossref] [PubMed] [PMC]
  • 59. Castro E, Turcinovic M, Platz J, Law I. Early mobilization: changing the mindset. Crit Care Nurse. 2015;35(4):e1-5; quiz e6. [Crossref] [PubMed]
  • 60. Parker A, Sricharoenchai T, Needham DM. Early rehabilitation in the intensive care unit: preventing physical and mental health impair ments. Curr Phys Med Rehabil Rep. 2013;1(4):307-14. [Crossref] [PubMed] [PMC]
  • 61. Peris A, Bonizzoli M, Iozzelli D, Migliaccio ML, Zagli G, Bacchereti A, et al. Early intra-inten sive care unit psychological intervention pro motes recovery from post traumatic stress disorders, anxiety and depression symptoms in critically ill patients. Crit Care. 2011;15(1):R41. Erratum in: Crit Care. 2011;15(2):418. [Crossref] [PubMed] [PMC]
  • 62. Czerwonka AI, Herridge MS, Chan L, Chu LM, Matte A, Cameron JI. Changing support needs of survivors of complex critical illness and their family caregivers across the care continuum: a qualitative pilot study of Towards RE COVER. J Crit Care. 2015;30(2):242-9. [Crossref] [PubMed]
  • 63. Petrinec AB, Mazanec PM, Burant CJ, Hoffer A, Daly BJ. Coping strategies and posttrau matic stress symptoms in post-ICu family de cision makers. Crit Care Med. 2015;43(6): 1205-12. [Crossref] [PubMed] [PMC]
  • 64. ullman AJ, Aitken LM, Rattray J, Kenardy J, Le Brocque R, MacGillivray S, et al. Diaries for recovery from critical illness. Cochrane Database Syst Rev. 2014;2014(12): CD010468. [Crossref] [PubMed] [PMC]
  • 65. Garrouste-Orgeas M, Coquet I, Périer A, Tim sit JF, Pochard F, Lancrin F, et al. Impact of an intensive care unit diary on psychological dis tress in patients and relatives*. Crit Care Med. 2012;40(7):2033-40. [Crossref] [PubMed]
  • 66. Jones C, Bäckman C, Griffiths RD. Intensive care diaries and relatives' symptoms of post traumatic stress disorder after critical illness: a pilot study. Am J Crit Care. 2012;21(3):172-6. [Crossref] [PubMed]
  • 67. Barr J, Fraser GL, Puntillo K, Ely EW, Gélinas C, Dasta JF, et al; American College of Critical Care Medicine. Clinical practice guidelines for the management of pain, agitation, and delir ium in adult patients in the intensive care unit. Crit Care Med. 2013;41(1):263-306. [Crossref] [PubMed]
  • 68. Ely EW. The ABCDEF bundle: science and philosophy of how ICu liberation serves pa tients and families. Crit Care Med. 2017;45(2):321-30. [Crossref] [PubMed] [PMC]
  • 69. Balas MC, Vasilevskis EE, Olsen KM, Schmid KK, Shostrom V, Cohen MZ, et al. Effective ness and safety of the awakening and breath ing coordination, delirium monitoring/ management, and early exercise/mobility bun dle. Crit Care Med. 2014;42(5):1024-36. [Crossref] [PubMed] [PMC]
  • 70. Salluh Jorge IF, Wang H, Schneider EB, Na garaja N, Yenokyan G, Damluji A, et al. Out come of delirium in critically ill patients: systematic review and meta-analysis. BMJ. 2015;350:h2538. [Crossref] [PubMed] [PMC]
  • 71. Warlan H, Howland L. Posttraumatic stress syndrome associated with stays in the inten sive care unit: importance of nurses' involve ment. Crit Care Nurse. 2015;35(3):44-52; quiz 54. [Crossref] [PubMed]
  • 72. Teixeira C, Rosa RG. [Post-intensive care out patient clinic: is it feasible and effective? A lit erature review). Rev Bras Ter Intensiva. 2018;30(1):98-111. [Crossref] [PubMed] [PMC]
  • 73. Van Der Schaaf M, Bakhshi-Raiez F, Van Der Steen M, Dongelmans DA, De Keizer NF. Recommendations for intensive care follow-up clinics; report from a survey and conference of Dutch intensive cares. Minerva Anestesiol. 2015;81(2):135-44. [PubMed]
  • 74. Lautrette A, Darmon M, Megarbane B, Joly LM, Chevret S, Adrie C, et al. A communica tion strategy and brochure for relatives of pa tients dying in the ICu. N Engl J Med. 2007;1;356(5):469-78. Erratum in: N Engl J Med. 2007;12;357(2):203. [Crossref] [PubMed]
  • 75. Curtis JR, Treece PD, Nielsen EL, Gold J, Ciechanowski PS, Shannon SE, et al. Ran domized trial of communication facilitators to reduce family distress and intensity of end-of life care. Am J Respir Crit Care Med. 2016;15;193(2):154-62. [Crossref] [PubMed] [PMC]
  • 76. Sundararajan K, Sullivan TR, Chapman M. Determinants of family satisfaction in the in tensive care unit. Anaesth Intensive Care. 2012;40(1):159-65. Erratum in: Anaesth In tensive Care. 2012;40(2):351. [Crossref] [PubMed]
APA Erbay Dalli O, Kelebek Girgin N, Kahveci F (2021). Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu. , 36 - 45. 10.5336/anesthe.2020-80057
Chicago Erbay Dalli Oznur,Kelebek Girgin Nermin,Kahveci Ferda Sohret Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu. (2021): 36 - 45. 10.5336/anesthe.2020-80057
MLA Erbay Dalli Oznur,Kelebek Girgin Nermin,Kahveci Ferda Sohret Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu. , 2021, ss.36 - 45. 10.5336/anesthe.2020-80057
AMA Erbay Dalli O,Kelebek Girgin N,Kahveci F Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu. . 2021; 36 - 45. 10.5336/anesthe.2020-80057
Vancouver Erbay Dalli O,Kelebek Girgin N,Kahveci F Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu. . 2021; 36 - 45. 10.5336/anesthe.2020-80057
IEEE Erbay Dalli O,Kelebek Girgin N,Kahveci F "Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu." , ss.36 - 45, 2021. 10.5336/anesthe.2020-80057
ISNAD Erbay Dalli, Oznur vd. "Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu". (2021), 36-45. https://doi.org/10.5336/anesthe.2020-80057
APA Erbay Dalli O, Kelebek Girgin N, Kahveci F (2021). Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu. Türkiye Klinikleri Anesteziyoloji Reanimasyon Dergisi, 19(1), 36 - 45. 10.5336/anesthe.2020-80057
Chicago Erbay Dalli Oznur,Kelebek Girgin Nermin,Kahveci Ferda Sohret Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu. Türkiye Klinikleri Anesteziyoloji Reanimasyon Dergisi 19, no.1 (2021): 36 - 45. 10.5336/anesthe.2020-80057
MLA Erbay Dalli Oznur,Kelebek Girgin Nermin,Kahveci Ferda Sohret Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu. Türkiye Klinikleri Anesteziyoloji Reanimasyon Dergisi, vol.19, no.1, 2021, ss.36 - 45. 10.5336/anesthe.2020-80057
AMA Erbay Dalli O,Kelebek Girgin N,Kahveci F Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu. Türkiye Klinikleri Anesteziyoloji Reanimasyon Dergisi. 2021; 19(1): 36 - 45. 10.5336/anesthe.2020-80057
Vancouver Erbay Dalli O,Kelebek Girgin N,Kahveci F Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu. Türkiye Klinikleri Anesteziyoloji Reanimasyon Dergisi. 2021; 19(1): 36 - 45. 10.5336/anesthe.2020-80057
IEEE Erbay Dalli O,Kelebek Girgin N,Kahveci F "Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu." Türkiye Klinikleri Anesteziyoloji Reanimasyon Dergisi, 19, ss.36 - 45, 2021. 10.5336/anesthe.2020-80057
ISNAD Erbay Dalli, Oznur vd. "Hayatta Kalan Kritik Hastaların İhmal Edilen Sonuçları: Yoğun Bakım Sonrası Sendromu". Türkiye Klinikleri Anesteziyoloji Reanimasyon Dergisi 19/1 (2021), 36-45. https://doi.org/10.5336/anesthe.2020-80057