CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality

Objective: Most patients with coronavirus disease (COVID-19) have abnormalities of lym- phocyte subsets. This study aimed to determine the distribution of lymphocytes in patients with various severity levels of COVID-19 and to describe the relationship between the CD4 + T helper and prognosis. Materials and Methods: Adult (>18 years old) patients with COVID-19 who followed up in a tertiary hospital were included in the study prospectively. Demographic and clinical characteristics of the patients were obtained from the hospital records. Peripheral flow cy- tometry was studied in patients with different severity of COVID-19 and different progno- ses. Next, we analyzed the characteristics and predictive values of lymphocyte subsets in COVID-19 patients. Results: Totally 86 patients were included in the study, of which 21 (24.4%) had asymp- tomatic, 23 (26.7%) had mild/moderate, and 42 (48.8%) had severe/critical COVID-19. Severe/critical patients had lower lymphocyte levels and older age than asymptomatic pa- tients (p<0.001 and p<0.001, respectively). We determined that decreased CD4 + T cell ra- tio (p<0.001) and CD4 + /CD8 + ratio (p<0.001) were indicative of the severity of the disease. CD4 + T cell ratio on admission (odds ratio [OR]=0.858; p=0.033), day seven CD4 + T cell ratio (OR=0.840; p=0.029), and C-reactive protein (CRP) levels (OR=1.014; p=0.043) were prognostic factors for mortality. According to receiver operating characteristics (ROC) curve analysis, the area under the curve was greater than 0.9 for decreased CD4 + T cell ratio on admission and the seventh day. Conclusion: A low CD4 + T helper ratio predicts a poor prognosis. In combination with CRP, it can be used in clinical follow-up.

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APA	Eryilmaz-Eren E, koker M, A, hörmet öz h, ALTINTOP Y, SAATÇİ E, Şimşek S, Kılınç Toker A, topaloglu u, Yüksel R, AVCILAR H, Bestepe Dursun Z, Çelik İ (2023). CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality. , 23 - 30. 10.36519/idcm.2023.190
Chicago	Eryilmaz-Eren Esma,koker Mustafa Yavuz, Aysegul,hörmet öz hatice tuna,ALTINTOP Yasemin Ay,SAATÇİ Esma,Şimşek Sevil,Kılınç Toker Ayşin,topaloglu ulasserkan,Yüksel Recep Civan,AVCILAR HÜSEYIN,Bestepe Dursun Zehra,Çelik İlhami CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality. (2023): 23 - 30. 10.36519/idcm.2023.190
MLA	Eryilmaz-Eren Esma,koker Mustafa Yavuz, Aysegul,hörmet öz hatice tuna,ALTINTOP Yasemin Ay,SAATÇİ Esma,Şimşek Sevil,Kılınç Toker Ayşin,topaloglu ulasserkan,Yüksel Recep Civan,AVCILAR HÜSEYIN,Bestepe Dursun Zehra,Çelik İlhami CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality. , 2023, ss.23 - 30. 10.36519/idcm.2023.190
AMA	Eryilmaz-Eren E,koker M, A,hörmet öz h,ALTINTOP Y,SAATÇİ E,Şimşek S,Kılınç Toker A,topaloglu u,Yüksel R,AVCILAR H,Bestepe Dursun Z,Çelik İ CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality. . 2023; 23 - 30. 10.36519/idcm.2023.190
Vancouver	Eryilmaz-Eren E,koker M, A,hörmet öz h,ALTINTOP Y,SAATÇİ E,Şimşek S,Kılınç Toker A,topaloglu u,Yüksel R,AVCILAR H,Bestepe Dursun Z,Çelik İ CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality. . 2023; 23 - 30. 10.36519/idcm.2023.190
IEEE	Eryilmaz-Eren E,koker M, A,hörmet öz h,ALTINTOP Y,SAATÇİ E,Şimşek S,Kılınç Toker A,topaloglu u,Yüksel R,AVCILAR H,Bestepe Dursun Z,Çelik İ "CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality." , ss.23 - 30, 2023. 10.36519/idcm.2023.190
ISNAD	Eryilmaz-Eren, Esma vd. "CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality". (2023), 23-30. https://doi.org/10.36519/idcm.2023.190

APA	Eryilmaz-Eren E, koker M, A, hörmet öz h, ALTINTOP Y, SAATÇİ E, Şimşek S, Kılınç Toker A, topaloglu u, Yüksel R, AVCILAR H, Bestepe Dursun Z, Çelik İ (2023). CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality. Infectious diseases and clinical microbiology (Online), 5(1), 23 - 30. 10.36519/idcm.2023.190
Chicago	Eryilmaz-Eren Esma,koker Mustafa Yavuz, Aysegul,hörmet öz hatice tuna,ALTINTOP Yasemin Ay,SAATÇİ Esma,Şimşek Sevil,Kılınç Toker Ayşin,topaloglu ulasserkan,Yüksel Recep Civan,AVCILAR HÜSEYIN,Bestepe Dursun Zehra,Çelik İlhami CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality. Infectious diseases and clinical microbiology (Online) 5, no.1 (2023): 23 - 30. 10.36519/idcm.2023.190
MLA	Eryilmaz-Eren Esma,koker Mustafa Yavuz, Aysegul,hörmet öz hatice tuna,ALTINTOP Yasemin Ay,SAATÇİ Esma,Şimşek Sevil,Kılınç Toker Ayşin,topaloglu ulasserkan,Yüksel Recep Civan,AVCILAR HÜSEYIN,Bestepe Dursun Zehra,Çelik İlhami CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality. Infectious diseases and clinical microbiology (Online), vol.5, no.1, 2023, ss.23 - 30. 10.36519/idcm.2023.190
AMA	Eryilmaz-Eren E,koker M, A,hörmet öz h,ALTINTOP Y,SAATÇİ E,Şimşek S,Kılınç Toker A,topaloglu u,Yüksel R,AVCILAR H,Bestepe Dursun Z,Çelik İ CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality. Infectious diseases and clinical microbiology (Online). 2023; 5(1): 23 - 30. 10.36519/idcm.2023.190
Vancouver	Eryilmaz-Eren E,koker M, A,hörmet öz h,ALTINTOP Y,SAATÇİ E,Şimşek S,Kılınç Toker A,topaloglu u,Yüksel R,AVCILAR H,Bestepe Dursun Z,Çelik İ CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality. Infectious diseases and clinical microbiology (Online). 2023; 5(1): 23 - 30. 10.36519/idcm.2023.190
IEEE	Eryilmaz-Eren E,koker M, A,hörmet öz h,ALTINTOP Y,SAATÇİ E,Şimşek S,Kılınç Toker A,topaloglu u,Yüksel R,AVCILAR H,Bestepe Dursun Z,Çelik İ "CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality." Infectious diseases and clinical microbiology (Online), 5, ss.23 - 30, 2023. 10.36519/idcm.2023.190
ISNAD	Eryilmaz-Eren, Esma vd. "CD4⁺ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality". Infectious diseases and clinical microbiology (Online) 5/1 (2023), 23-30. https://doi.org/10.36519/idcm.2023.190