Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives
Yıl: 2023 Cilt: 30 Sayı: 2 Sayfa Aralığı: 142 - 152 Metin Dili: İngilizce DOI: 10.5505/vtd.2023.95881 İndeks Tarihi: 12-05-2023
Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives
Öz: Introduction: This study aimed to investigate the relationships between neurological soft signs (NSS), circadian preferences, and emotional regulation difficulties in patients with bipolar disorder (BD) and their unaffected first-degree relatives (FDRs). Materials and Methods: A total of 105 people (35 BD patients, 35 FDRs, and 35 healthy controls) enrolled in the study. They completed a sociodemographic information form, the Young Mania Rating Scale (YMRS), Hamilton Depression Rating Scale (HAM-D), Morningness-Eveningness Questionnaire (MEQ), Difficulties in Emotion Regulation Scale (DERS), and Neurological Evaluation Scale (NES). Results: NES motor coordination, complex motor movements, other subscale and total scores we re significantly higher in BD and FDRs compared to the control group. The subscales of the DERS including nonacceptance, goals, impulse, strategies, accessibility, and total DERS scores were also significantly higher in patients than the relative and control groups. A statistically positive, weak, and significant relationship emerged between the patient group’s ot her NES sub-dime nsion and the DERS sub-dimensions of impuls e and awareness. Meanwhile, significant relationship was found in the FDRs between NSS and the NES sub-dimensions emotional integration and complex motor movements. A significant relationship was also found between the DERS sub- dimension nonacceptance and the NSS sub-dimension complex motor movements. Conclusion: This study discovered that NSS are associated with negative emotional regulation strategies in patients with BD during in euthymic period and FDRs. NSS and circadian preferences may be endophenotype candidates for BD.
Anahtar Kelime: Bipolar Bozuklukta ve Birinci Derece Yakınlarında Silik Nörolojik Belirtiler, Sirkadiyen Tercihler ve Duygu Düzenleme
Öz: Amaç: Bu çalışmanın amac ı bipolar bozukluğu (BB) olan hastalar ve birinci derece akrabalarında (BDA) silik nörolojik belirtiler (SNB), sirkadiyen tercihler ve duygu düzenleme güçlükleri arasındaki ilişkileri araştırmaktır. Gereç ve Yöntem: Çalışmaya toplam 105 kişi (35 BB, 35 BDA ve 35 sağlıklı kontrol) al ındı. Sosyodemografik bilgi formu, Young Mani Derecelendirme Ölçeği (YMDÖ), Hamilton Depresyon Derecelendirme Ölçeği (HAM-D), Sabahlılık Akşamlılık Ölçeği (SAÖ), Duygu Düzenleme Güçlüğü Ölçeği (DDGÖ) ve Nörolojik Değerlendirme Ölçeği (NDÖ) dolduruldu. Bulgular: BB ve BDA’da NDÖ motor koordinasyon, karma şık motor hareketler ve di ğer alt ölçek ve toplam puanları kontrol grubuna göre anlamlı derecede yüksek saptandı. DDGÖ kabul etmeme, hedefler, dürtü, stratejiler, erişilebilirlik alt ölçek ve toplam puanları BB’de BDA ve kontrol gruplarına göre anlamlı olarak daha yüksekti. BB’de DDGÖ di ğer alt ölçeği ile DDGÖ dürtü ve farkındalık alt boyutları arasında anlamlı ilişki saptandı. BDA grubunda SNB ile NDÖ alt boyutları olan duygusal bütünleşme ve karmaşık motor hareketler arasında anlamlı bir ilişki bulundu. DDGÖ kabul etmeme ile SNB karmaşık motor hareketler alt boyutları arasında da anlamlı ilişki bulundu. Sonuç: Bu çalışmada ötimik dönemdeki BB’de ve BDA’larda SNB'nin olumsuz duygu düzenl eme stratejileri ile ilişkili olduğu saptandı. SNB ve sirkadiyen tercihler BB için endofenotip adayları olabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Ferrari AJ, Stockings E, Khoo JP, Erskine HE, Degenhardt L, Vos T et al. The prevalence and burden of bipolar disorder: findings from the Global Burden of Disease Study 2013. Bipolar Disord 2016;18(5):440- 450.
- 2. Hu B, Cha J, Fullerton JM, Hesam-Shariati S, Nakamura K, Nurnberger JI et al. Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach. Transl Psychiatry 2022;12(1):137.
- 3. Bora E, Akgül Ö, Ceylan D, Özerdem A. Neurological soft signs in bipolar disorder in comparison to healthy controls and schizophrenia: A meta-analysis. Eur Neuropsychopharmacol 2018;28(11):1185- 1193.
- 4. Chrobak AA, Soltys Z, Dudek D, Siwek M. Neurological and cerebellar soft signs in bipolar disorder: The role of staging, type and history of psychotic symptoms. Prog Neuropsychopharmacol Biol Psychiatry 2023;121:110673.
- 5. Kloiber S, Rosenblat JD, Husain MI, Ortiz A, Berk M, Quevedo J et al. Neurodevelopmental pathways in bipolar disorder. Neurosci Biobehav Rev 2020;112:213-226.
- 6. Selvi Y, Beşiroğlu L, Aydın A. Chronobiology and Mood disorders. Curr Approaches Psychiatry 2011;3:368-86.
- 7. Roybal DJ, Chang KD, Chen MC, Howe ME, Gotlib IH, Singh MK. Characterization and factors associated with sleep quality in adolescents with bipolar I disorder. Child Psychiatry Hum Dev 2011;42(6):724-740.
- 8. Henry C, Van den Bulke D, Bellivier F, Roy I, Swendsen J, M'Baïlara K et al. Affective lability and affect intensity as core dimensions of bipolar disorders during euthymic period. Psychiatry Res 2008;159:1- 6.
- 9. Carruthers SP, Rossell SL, Murray G, Karantonis J, Furlong LS, Van Rheenen TE. Mindfulness, mood symptom tendencies and quality of life in bipolar disorder: An examination of the mediating influence of emotion regulation difficulties. J Affect Disord 2022;298:166-172.
- 10. Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978;133:429-435.
- 11. Karadağ FOE, Yalçın Aran F, Erten E. Reliability and validity of Turkish translation of Young Mania Rating Scale. Turk Psikiyatri Derg 2001;13:107-114.
- 12. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56-62.
- 13. Akdemir A, Orsel S, Dag I, Turkcapar H, Iscan N, Ozbay H. Validity and clinical use of Hamilton Depression Rating Scale. J Psychiatry Psychol Psychopharmacol 1996;4:251–259.
- 14. Horne JA, Ostberg O. A self-assessment questionnaire to determine morningness eveningness in human circadian rhythms. Int J Chronobiol 1976;4(2):97-110.
- 15. Agargun MY, Cilli AS, Boysan M, Selvi Y, Gulec M, Kara H. Turkish version of Morningness-Eveningness Questionnaire (MEQ). Sleep and Hypnosis 2007;9(1):16- 23.
- 16. Gratz KL, Roemer L. Multidimensional assessment of emotion regulation and dysregulation: Development, factor structure, and initial validation of the Difficulties in Emotion Regulation Scale. Psychopathology and Behavioral Assessment 2004;26: 41-54.
- 17. Ruganci RN, Gençöz T. Psychometric properties of a Turkish version of the Difficulties in Emotion Regulation Scale. J Clin Psychol 2010;66(4):442-455.
- 18. Buchanan RW, Heinrichs DW. Neurological Evaluation Scale (NES): a structured instrument for the assesment of neurological signs in schizophrenia. Psychiatry Res 1989; 27(3): 335-350.
- 19. Bombin I, Arango CRW. Significance and meaning of neurological signs in schizophrenia: two decades later. Schizophr Bull 2005; 31: 962-977.
- 20. Chrobak AA, Soltys Z, Dudek D, Siwek M. Neurological and cerebellar soft signs in bipolar disorder: The role of staging, type and history of psychotic symptoms. Prog Neuropsychopharmacol Biol Psychiatry 2023;121:110673.
- 21. Tobar S, Hazem MA. comparative profile of neurological soft signs (NSS) in first degree relatives of schizophrenia, and bipolar disorder. Egypt J Neurol Psychiatry Neurosurg 2008;45:129–136.
- 22. Sharma S, Bhatia T, Mazumdar S, Deshpande SN. Neurological soft signs and cognitive functions: Amongst euthymic bipolar I disorder cases, non-affected first degree relatives and healthy controls. Asian J Psychiatr 2016; 22: 53–59.
- 23. Chen CH, Suckling J, Lennox BR, Ooi C, Bullmore ET. A quantitative meta-analysis of fMRI studies in bipolar disorder. Bipolar Disord 2011;13:1–15.
- 24. Gruber J, Kogan A, Mennin D, Murray G. Real-world emotion? An experience sampling approach to emotion experience and regulation in bipolar I disorder. J Abnorm Psychol 2013;122:971–983.
- 25. Saunders EF, Novick DM, Fernandez Mendoza J, Kamali M, Ryan KA, Langenecker SA et al. Sleep quality during euthymia in bipolar disorder: the role of clinical features, personality traits, and stressful life events. Int J Bipolar Disord 2013;1:16.
- 26. Dallaspezia S, Benedetti F. Chronobiology of bipolar disorder: therapeutic implication. Curr Psychiatry Rep 2015;17:606.
- 27. Pinho M, Sehmbi M, Cudney LE, Kauer Sant'anna M, Magalhães PV, Reinares M et al. The association between biological rhythms, depression, and functioning in bipolar disorder: a large multi-center study. Acta Psychiatr Scand 2016; 133(2): 102-108.
- 28. Melo MCA, Abreu RLC, Linhares Neto VB, de Bruin PFC, de Bruin VMS. Chronotype and circadian rhythm in bipolar disorder: A systematic review. Sleep Med Rev 2017;34:46-58.
- 29. Schlarb AA, Sopp R, Ambiel D, Grünwald J. Chronotype-related differences in childhood and adolescent aggression and antisocial behavior--a review of the literature. Chronobiol Int 2014;31(1):1-16.
| APA | Erkuş B, Guzel Ozdemir P, IŞIK M (2023). Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives. , 142 - 152. 10.5505/vtd.2023.95881 |
| Chicago | Erkuş Barış,Guzel Ozdemir Pinar,IŞIK MESUT Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives. (2023): 142 - 152. 10.5505/vtd.2023.95881 |
| MLA | Erkuş Barış,Guzel Ozdemir Pinar,IŞIK MESUT Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives. , 2023, ss.142 - 152. 10.5505/vtd.2023.95881 |
| AMA | Erkuş B,Guzel Ozdemir P,IŞIK M Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives. . 2023; 142 - 152. 10.5505/vtd.2023.95881 |
| Vancouver | Erkuş B,Guzel Ozdemir P,IŞIK M Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives. . 2023; 142 - 152. 10.5505/vtd.2023.95881 |
| IEEE | Erkuş B,Guzel Ozdemir P,IŞIK M "Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives." , ss.142 - 152, 2023. 10.5505/vtd.2023.95881 |
| ISNAD | Erkuş, Barış vd. "Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives". (2023), 142-152. https://doi.org/10.5505/vtd.2023.95881 |
| APA | Erkuş B, Guzel Ozdemir P, IŞIK M (2023). Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives. Van Tıp Dergisi, 30(2), 142 - 152. 10.5505/vtd.2023.95881 |
| Chicago | Erkuş Barış,Guzel Ozdemir Pinar,IŞIK MESUT Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives. Van Tıp Dergisi 30, no.2 (2023): 142 - 152. 10.5505/vtd.2023.95881 |
| MLA | Erkuş Barış,Guzel Ozdemir Pinar,IŞIK MESUT Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives. Van Tıp Dergisi, vol.30, no.2, 2023, ss.142 - 152. 10.5505/vtd.2023.95881 |
| AMA | Erkuş B,Guzel Ozdemir P,IŞIK M Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives. Van Tıp Dergisi. 2023; 30(2): 142 - 152. 10.5505/vtd.2023.95881 |
| Vancouver | Erkuş B,Guzel Ozdemir P,IŞIK M Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives. Van Tıp Dergisi. 2023; 30(2): 142 - 152. 10.5505/vtd.2023.95881 |
| IEEE | Erkuş B,Guzel Ozdemir P,IŞIK M "Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives." Van Tıp Dergisi, 30, ss.142 - 152, 2023. 10.5505/vtd.2023.95881 |
| ISNAD | Erkuş, Barış vd. "Neurological Soft Signs, Circadian Preferences and Emotion Regulation in Bipolar Disorder and First- Degree Relatives". Van Tıp Dergisi 30/2 (2023), 142-152. https://doi.org/10.5505/vtd.2023.95881 |
