Introduction: Patent ductus arteriosus (PDA) is the most common congenital heart disease in preterm infants. Surgical ligation is still the gold standard technique, especially in low birth weight patients. To reduce surgical trauma and possible complications, the anterior mini-thoracotomy (AMT) technique has been defined. However, conventional lateral thoracotomy (LT) is still the method preferred by many centers today. In our study, we aimed to compare the early results of preterm infants who underwent PDA ligation wi th two different surgical techniques in a newly established center. Materials and Methods: A total of 26 patients (12 males, 14 females; median gestational age at surgery 32 weeks [IQR: 29- 37]) who underwent surgical PDA ligation in preterm infants between January 2018 and February 2020 were retrospectively analyzed. PDA closure was performed through the left anterior mini-thoracotomy approach in 15 of the patients and left lateral thoracotomy in 11 patients. The early outcomes of the two groups were compared. Results: The median weight at operation was 1000 g (IQR: 720-1200) in AMT group and 1200 g (IQR: 1000 – 2800) in the LT group. The difference between weights at operation was found statistically significant. The operation time of the AMT group was found to be statistically significantly shorter. Conclusion: Anterior mini-thoracotomy technique provides an effective surgical closure in the low-weight preterm infant at least lateral thoracotomy technique. Based on the results of our series and our opinion, it should be considered the first choice surgical method, especially in very low and extremely low- weight preterm infants.