A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement
Yıl: 2023 Cilt: 30 Sayı: 2 Sayfa Aralığı: 209 - 212 Metin Dili: İngilizce DOI: 10.5505/vtd.2023.80664 İndeks Tarihi: 12-05-2023
A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement
Öz: MOGAD (Myelin Oligodendrocyte Glycoprotein Antibody Disease) is caused by antibodies against the myelin oligodendrocyte glycoprotein (MOG) found on the surfaces of oligodendrocytes and its damage. MOGAD and Neuromyelitis Optica Spectrum Disorders (NMOSD) are very rare autoimmune inflammatory demyelinating diseases of the central nervous system that are often se en with joint involvement of the optic nerves and spinal cord. MOGAD can be confused with Multiple Sclerosis (MS) or NMOSD, which are more common in the community, due to its clinical presentations that may be similar and its characteristic to progress with habitual attacks. Although the clinical course of these three diseases is similar, their diagnosis and treatment are different; It is important to avoid diagnostic confusion, to make differential diagnosis of patients with other diseases and not to waste time for treatment, to prevent possible disability and disability. In addition, Optic Neuritis is an inflammatory disease of the optic nerve and is very common in patients with Multiple Sclerosis, and it can often be the first clinical presentation of the disease. However, being the first and early finding in other very rare demyelinating diseases can cause diagnostic confusion. In this article, we wanted to present the importance of optic neuritis, demyelinating diseases and differential diagnosis in a İnformed consent of the patient was obtaine d, 51-years-old female patient who had bilateral optic neuritis attacks at different times, in the light of the literature.
Anahtar Kelime: Vaka Takdimi: Optik Nöritin Eşlik Ettiği Spinal Tutulumun Olmadığı Nadir Bir MOGAD Vakası
Öz: MOGAD (Myelin Oligodendrocyte Glycoprotein Antibody Disease), oligodendrositlerin yüzeylerinde bulunan miyelin oligodendrosit glikoproteinine (MOG) kar şı oluşan antikor ve onun verdi ği hasardan kaynaklanır. MOGAD ve NöroMiyelitis Optica Spektrum Disorders (NMOSD), sıklıkla optik sinirler ve omuriliğin birlikte tutulumu ile görülen merkezi sinir sisteminin çok nadir otoimmün inflamat uar demiyelinizan hastalıklarıdır. MOGAD, benzer olabilecek klinik tabloları ve alışılmış ataklarla seyretme özelliğinden dolayı toplumda daha s ık görülen Multipl Skleroz (MS) veya NMOSD ile karıştırılabilir. Bu üç hastalığın her ne kadar klinik seyirl eri benzer olsa da tan ı ve tedavileri farklı olduğundan; tanı karışıklığı oluşmaması, hastalar ın di ğer hastalıklarla ayırıcı tanısının yap ılması ve tedavi için zaman kaybetmemesi, oluşabilecek disabilite ve engelliliğin önlenmesi açısından önemlidir. Ayrıca, Optik Nörit, optik sinirin inflamatuar hastalığıdır ve Multiple Skleroz hastalarında çok s ık görülmekte, çoğu zaman da hastal ığın ilk klinik prezentasyonu olabilmektedir. Ancak çok nadir görülen diğer demiyelinizan hastalıklarda ilk ve erken bulgu olmas ı tanı karışıklığı oluşturabilmektedir. Biz bu yazımızda, aydınlatılmış hasta onamı alınan, farklı zamanlarda bilateral optik nörit ata ğı geçiren, 51 yaş bayan hasta özelinde optik nörit, demiyelinizan hastal ıklar ve ayırıcı tanının önemini literatür eşliğinde sunmak istedik.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
- 1. Reindl M, Di Pauli F, Rostásy K, Berger T. The spectrum of MOG autoantibody associated demyelinating diseases. Nat Rev Neurol 2013; 9(8): 455-461.
- 2. Eraksoy M, G Akman-Demir. Merkezi Sinir Sisteminin Miyelin Hastalıkları. İçinde: Öge AE, B Baykan, Editörler. İstanbul Tıp Fakültesi Temel ve Klinik Bilimler Ders Kitapları. Nöroloji. 2. Baskı. İstanbul: Nobel Yayınları; 2015. s. 603-648
- 3. Narayan R, Simpson A, Fritsche K, Salama S, Pardo S, Mealy M, Levy M. MOG antibody disease: a review of MOG antibody seropositive neuromyelitis optica spectrum disorder. Mult scler relat disord 2018; 25: 66-72.
- 4. Ungureanu A, Seze J, Ahle G. Myelin oligodendrocyte glycoprotein antibodies in neuromyelitis optica spectrum disorder. Rev Neurol 2018; 174(10): 675-679.
- 5. Louapre C, Papeix C, Lubetzki C. Multiple sclerosis and aging. Geriatr Psychol Neuropsychiatr Vieil 2017; 15(4): 402-408.
- 6. Dutra BG, da Rocha AJ, Nunes RH, Maia ACM. Neuromyelitis Optica Spectrum Disorders: Spectrum of MR Imaging Findings and Their Differential Diagnosis. RadioGraphics 2018; 38(1): 169-193.
- 7. Tajfirouz DA, Bhatti MT, Chen JJ. Clinical characteristics and treatment of MOG-IgG– associated optic neuritis. Curr neurol neurosci rep 2019; 19(12): 1-8
- 8. Ramanathan S, Dale R C, Brilot F. Anti MOG antibody: the history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination. Autoimmun Rev 2016; 15(4): 307-324.
- 9. Jarius S, Paul F, Aktas O, Asgari N, Dale R C, De Seze J, et al. MOG encephalomyelitis: international recommendations on diagnosis and antibody testing. J neuroinflammation 2018; 15(1): 1-10.
- 10. Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K, et al. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 1: frequency, syndrome specificity, influence of disease activity, long-term course, association with AQP4-IgG, and origin. J Neuroinflammation 2016; 13(1): 1-16.
- 11. Nakashima I. Anti myelin oligodendrocyte glycoprotein antibody in demyelinating diseases. Clin Exp Neuroimmunol 2015; 6: 59-63.
- 12. Shahriari M, Sotirchos E S, Newsome S D, Yousem D M. MOGAD: How It Differs From and Resembles Other Neuroinflammatory Disorders. Am J Roentgenol 2021; 216(4): 1031-1039.
- 13. Takahashi K, Takeuchi H, Fukai R, Nakamura H, Morihara K, Higashiyama Y, et al. Case Report: Anti-MOG Antibody Seroconversion Accompanied by Dimethyl Fumarate Treatment. Front Immunol 2021; 12: 347.
| APA | akünal türel c, HALICIOĞLU S (2023). A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement. , 209 - 212. 10.5505/vtd.2023.80664 |
| Chicago | akünal türel canan,HALICIOĞLU Sıddıka A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement. (2023): 209 - 212. 10.5505/vtd.2023.80664 |
| MLA | akünal türel canan,HALICIOĞLU Sıddıka A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement. , 2023, ss.209 - 212. 10.5505/vtd.2023.80664 |
| AMA | akünal türel c,HALICIOĞLU S A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement. . 2023; 209 - 212. 10.5505/vtd.2023.80664 |
| Vancouver | akünal türel c,HALICIOĞLU S A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement. . 2023; 209 - 212. 10.5505/vtd.2023.80664 |
| IEEE | akünal türel c,HALICIOĞLU S "A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement." , ss.209 - 212, 2023. 10.5505/vtd.2023.80664 |
| ISNAD | akünal türel, canan - HALICIOĞLU, Sıddıka. "A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement". (2023), 209-212. https://doi.org/10.5505/vtd.2023.80664 |
| APA | akünal türel c, HALICIOĞLU S (2023). A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement. Van Tıp Dergisi, 30(2), 209 - 212. 10.5505/vtd.2023.80664 |
| Chicago | akünal türel canan,HALICIOĞLU Sıddıka A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement. Van Tıp Dergisi 30, no.2 (2023): 209 - 212. 10.5505/vtd.2023.80664 |
| MLA | akünal türel canan,HALICIOĞLU Sıddıka A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement. Van Tıp Dergisi, vol.30, no.2, 2023, ss.209 - 212. 10.5505/vtd.2023.80664 |
| AMA | akünal türel c,HALICIOĞLU S A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement. Van Tıp Dergisi. 2023; 30(2): 209 - 212. 10.5505/vtd.2023.80664 |
| Vancouver | akünal türel c,HALICIOĞLU S A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement. Van Tıp Dergisi. 2023; 30(2): 209 - 212. 10.5505/vtd.2023.80664 |
| IEEE | akünal türel c,HALICIOĞLU S "A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement." Van Tıp Dergisi, 30, ss.209 - 212, 2023. 10.5505/vtd.2023.80664 |
| ISNAD | akünal türel, canan - HALICIOĞLU, Sıddıka. "A Rare Case Report: MOGAD with Optic Neuritis- without Spinal İnvolvement". Van Tıp Dergisi 30/2 (2023), 209-212. https://doi.org/10.5505/vtd.2023.80664 |
