TY  - JOUR
TI  - ASSOCIATING eNOS GENE VARIANTS WITH COVID-19 SUSCEPTIBILITY IN THE TURKISH POPULATION
AB  - Objective: COVID-19 is a serious respiratory and vascular disease that impairs the protective function of the endothelial barrier. Endothelial nitric oxide synthase (eNOS), the most important isoform for nitric oxide (NO) production, is mostly expressed in endothelial cells. Therefore, this study aims to evaluate whether eNOS G894T and variable tandem repeat number (VNTR) functional variants show predisposition to developing COVID-19. Materials and Methods: The study includes a total of 384 subjects (284 COVID-19 patients and 100 healthy controls). Two eNOS gene variants (G894T and VNTR) were genotyped using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods, with the results being evaluated using statistical methods. Results: A significant association has been identified between eNOS G894T and COVID-19. For the eNOS G894T variant, the T/T genotype (p=0.035) and T allele carriers (p=0.030) appear to have an increased risk of developing COVID-19. The eNOS G894T G/G genotype (p=0.030) was more common in the control group compared to the patient group. No significant difference was found between groups regarding the eNOS VNTR genotype and allele frequencies (p˃0.05). The genotypes of the patient and control groups for these variants were in Hardy- Weinburg equilibrium (HWE). Conclusion: These results provide evidence supporting the hypothesis that the eNOS G894T variant is associated with an increased risk of developing COVID-19 in the Turkish population. These findings may lead to the emergence of new treatment options. Further research is required to understand the molecular mechanisms involved in the pathogenesis of the disease.
AU  - PEHLİVAN, MUSTAFA
AU  - Tukek, Tufan
AU  - Oyacı, Yasemin
AU  - Konyaoğlu, Hilal
AU  - Kose, Murat
AU  - Medetalibeyoglu, Alpay
AU  - pehlivan, sacide
AU  - Senkal, Naci
AU  - Cebeci, Timurhan
AU  - ÖNEL, MUSTAFA
AU  - Yeşil, Gözde
AU  - Isoglu-Alkac, Ummuhan
DO  - 10.26650/IUITFD.1211888
PY  - 2023
JO  - İstanbul Tıp Fakültesi Dergisi
VL  - 86
IS  - 1
SN  - 1305-6441
SP  - 1
EP  - 6
DB  - TRDizin
UR  - http://search/yayin/detay/1170290
ER  -