Objective: In many countries worldwide, medical knowledge of PIDs remains insufficient, which leads to late diagnosis, higher morbidity, a shorter life span, and worse quality of life. This study aims to assess the level of awareness and knowledge of physicians working in Turkey about PIDs. Materials and Methods: Between June and September 2019, a questionnaire regarding the findings, diagnosis, and treatment of PIDs was sent via social media to physicians from various medical specialties. The research was conducted using the data collected from physicians who agreed to participate in the study and completed the questionnaire. Results: The results of 661 participants (50.8%) who completed the entire survey were evaluated. While the majority of the questions in the general information section about PIDs were correctly answered by more than 80% of the physicians, knowledge about warning signs, laboratory findings, and treatment methods was less robust. Remarkably, pediatricians’ knowledge was slightly higher than that of other specialties. Only a small part of family physicians and internists felt competent; 29.7% of pediatricians, 8.2% of family physicians, and 19% of internists felt worried; and half of the family physicians and internists stated they referred these patients directly without performing any evaluation. Conclusion: It may be possible to perform intervention programs to enhance primary care for PIDs in Turkey using this information regarding physicians’ PID management approaches, views, and beliefs.