Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma
Yıl: 2022 Cilt: 60 Sayı: 3 Sayfa Aralığı: 22 - 28 Metin Dili: İngilizce DOI: 10.4274/tao.2022.2022-6-17 İndeks Tarihi: 14-05-2023
Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma
Öz: Objective: Despite all the recent advancements, larynx cancer has shown no improvement in survival rates. The aim of this study was to investigate the expressions of toll-like receptor (TLR)- 2, -3, and -4 genes, and determine any relationships with the histopathologic characteristics of the disease. Methods: This retrospective study included 50 subjects who underwent total or partial laryngectomy with an open surgical method for larynx squamous cell carcinoma. Measurements of TLRs-2, -3, and -4 expression values were taken with quantitative real time-polymerase chain reaction in normal tissue and tumor tissue samples of the patients. Results: Evaluations were made of TLR-2, -3, and -4 mRNA expressions according to 2-∆∆CT calculations in 50 subjects with larynx cancer. When the tumor tissue was compared with the healthy tissue from the same subjects, reductions were determined in TLR expression in 86%, 84%, and 82%, respectively. This reduction in each gene expression was statistically significant (p<0.001). No statistically significant correlation was determined between the change in TLR-2, -3, and -4 expression and the histopathologic characteristics of the disease. Conclusion: The data obtained in this study demonstrated that TLR-2, -3, and -4 expressions were reduced in larynx squamous cell cancer. The results of further studies targeting these genes would be useful in the diagnosis and treatment of the disease.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | EKER C, inan c, ÇELEBİ A, Gözen E, karaman e (2022). Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma. , 22 - 28. 10.4274/tao.2022.2022-6-17 |
| Chicago | EKER CAGLAR,inan caner,ÇELEBİ ASUMAN,Gözen Emine Deniz,karaman emin Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma. (2022): 22 - 28. 10.4274/tao.2022.2022-6-17 |
| MLA | EKER CAGLAR,inan caner,ÇELEBİ ASUMAN,Gözen Emine Deniz,karaman emin Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma. , 2022, ss.22 - 28. 10.4274/tao.2022.2022-6-17 |
| AMA | EKER C,inan c,ÇELEBİ A,Gözen E,karaman e Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma. . 2022; 22 - 28. 10.4274/tao.2022.2022-6-17 |
| Vancouver | EKER C,inan c,ÇELEBİ A,Gözen E,karaman e Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma. . 2022; 22 - 28. 10.4274/tao.2022.2022-6-17 |
| IEEE | EKER C,inan c,ÇELEBİ A,Gözen E,karaman e "Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma." , ss.22 - 28, 2022. 10.4274/tao.2022.2022-6-17 |
| ISNAD | EKER, CAGLAR vd. "Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma". (2022), 22-28. https://doi.org/10.4274/tao.2022.2022-6-17 |
| APA | EKER C, inan c, ÇELEBİ A, Gözen E, karaman e (2022). Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma. Turkish archives of otorhinolaryngology , 60(3), 22 - 28. 10.4274/tao.2022.2022-6-17 |
| Chicago | EKER CAGLAR,inan caner,ÇELEBİ ASUMAN,Gözen Emine Deniz,karaman emin Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma. Turkish archives of otorhinolaryngology 60, no.3 (2022): 22 - 28. 10.4274/tao.2022.2022-6-17 |
| MLA | EKER CAGLAR,inan caner,ÇELEBİ ASUMAN,Gözen Emine Deniz,karaman emin Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma. Turkish archives of otorhinolaryngology , vol.60, no.3, 2022, ss.22 - 28. 10.4274/tao.2022.2022-6-17 |
| AMA | EKER C,inan c,ÇELEBİ A,Gözen E,karaman e Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma. Turkish archives of otorhinolaryngology . 2022; 60(3): 22 - 28. 10.4274/tao.2022.2022-6-17 |
| Vancouver | EKER C,inan c,ÇELEBİ A,Gözen E,karaman e Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma. Turkish archives of otorhinolaryngology . 2022; 60(3): 22 - 28. 10.4274/tao.2022.2022-6-17 |
| IEEE | EKER C,inan c,ÇELEBİ A,Gözen E,karaman e "Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma." Turkish archives of otorhinolaryngology , 60, ss.22 - 28, 2022. 10.4274/tao.2022.2022-6-17 |
| ISNAD | EKER, CAGLAR vd. "Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma". Turkish archives of otorhinolaryngology 60/3 (2022), 22-28. https://doi.org/10.4274/tao.2022.2022-6-17 |
