TY  - JOUR
TI  - Investigation of Toll-like Receptor-2, -3 and -4 Gene Expressions in Larynx Squamous Cell Carcinoma
AB  - Objective: Despite all the recent advancements, larynx cancer has shown no improvement in survival rates. The aim of this study was to investigate the expressions of toll-like receptor (TLR)- 2, -3, and -4 genes, and determine any relationships with the histopathologic characteristics of the disease. Methods: This retrospective study included 50 subjects who underwent total or partial laryngectomy with an open surgical method for larynx squamous cell carcinoma. Measurements of TLRs-2, -3, and -4 expression values were taken with quantitative real time-polymerase chain reaction in normal tissue and tumor tissue samples of the patients. Results: Evaluations were made of TLR-2, -3, and -4 mRNA expressions according to 2-∆∆CT calculations in 50 subjects with larynx cancer. When the tumor tissue was compared with the healthy tissue from the same subjects, reductions were determined in TLR expression in 86%, 84%, and 82%, respectively. This reduction in each gene expression was statistically significant (p<0.001). No statistically significant correlation was determined between the change in TLR-2, -3, and -4 expression and the histopathologic characteristics of the disease. Conclusion: The data obtained in this study demonstrated that TLR-2, -3, and -4 expressions were reduced in larynx squamous cell cancer. The results of further studies targeting these genes would be useful in the diagnosis and treatment of the disease.
AU  - inan, caner
AU  - Gözen, Emine Deniz
AU  - karaman, emin
AU  - EKER, CAGLAR
AU  - ÇELEBİ, ASUMAN
DO  - 10.4274/tao.2022.2022-6-17
PY  - 2022
JO  - Turkish archives of otorhinolaryngology 
VL  - 60
IS  - 3
SN  - 2667-7466
SP  - 22
EP  - 28
DB  - TRDizin
UR  - http://search/yayin/detay/1170469
ER  -