Background: In the literature, the dental implant survival rate has been reported one hundred percent in immunosuppressed patients after a solid organ transplant (SOT). There is no previously published dental implant failure that has been reported on immunosuppressed renal transplant, which is the most common SOT therapy. Case Report: The case presented is that of a 66-years old male edentulous patient suffering from lack of functional prosthesis and who received a renal transplant two years ago. No complications such as infection, radiolucency, or pus were detected after two dental implants were placed in the mandible and after three months recovery period. The right mandibular dental implant failure occurred due to compression of the dental implant and healing head during the delivery of the patient’s removable prosthesis. Following implant socket healing after two months, the 4.8 mm diameter implant was placed immediately after. Osseointegration was completed uneventfully, and the patient was successfully rehabilitated with a two implant-retained mandibular overdenture prosthesis. The implant restoration was performing well with stable Peri-implant bone levels have shown minimal marginal bone loss at a 2-year follow-up. Conclusion: Treatment of combined immunosuppressive medication used in renal transplant patients after dental implant rehabilitation, as well as accompanying chronic diseases, should be performed considering the possibility of failure in dental implant applications. In this case report, the causes of implant failure were reported patients who received dental implant treatment after renal transplantation from a cadaver.