Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding

Ozbaykus, Abdullah Canberk; Ekici, Hüsamettin; Dizdaroglu, Hazal; KUMANDAS, ALI; Midi, Ahmet; balık, mehmet sabri; Yesilada, Erdem

doi:10.14235/bas.galenos.2021.5544

Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding

Hüsamettin EKİCİ, (Kırıkkale Üniversitesi, Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Kırıkkale, Türkiye)

ALİ KUMANDAŞ, (Kırıkkale Üniversitesi, Veteriner Fakültesi, Cerrahi Anabilim Dalı, Kırıkkale, Türkiye)

Abdullah Canberk ÖZBAYKUŞ, (Bahçeşehir Üniversitesi, Tıp Fakültesi, İstanbul, Türkiye)

Hazal Dizdaroglu, (Bahçeşehir Üniversitesi, Tıp Fakültesi, İstanbul, Türkiye)

Ahmet MİDİ, (Bahçeşehir Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye)

Mehmet Sabri BALIK, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Ortopedi ve Travmatoloji Anabilim Dalı, Rize, Türkiye)

Erdem YEŞİLADA (Yeditepe Üniversitesi, Eczacılık Fakültesi, Farmakognozi ve Fitoterapi Anabilim Dalı, İstanbul, Türkiye)

Bezmiâlem Science

2 0

Yıl: 2022 Cilt: 10 Sayı: 1 Sayfa Aralığı: 88 - 95 Metin Dili: İngilizce DOI: 10.14235/bas.galenos.2021.5544 İndeks Tarihi: 15-05-2023

Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding

Öz:

Objective: The aim of this study is to evaluate the efficacy of the Algan Hemostatic Agent (AHA) available in three different physical form (liquid, powder and sponge absorbed) in the femoral artery incision model in rats. Methods: A total of sixty-four 5-7 weeks old rats were used in the study. Rats were randomly divided into 8 groups each consisting of eight rats (4 groups heparinized and 4 groups non-heparinized). An experimental femoral artery incision was created. As a control, physiological saline absorbed sponge was applied. AHA liquid, AHA powder and AHA sponge absorbed forms were applied to the experimental groups. Results: Upon application to the bleeding sites, all the AHA forms stopped bleeding in a significantly shorter time compared to the control group (p<0.05). In contrast, bleeding in control group could not be controlled within 4 minutes. The best result was in AHA powder form and it was able to control bleeding in the non-heparinized group at 87.5% in the first minute and 12.5% in the second minute. In the heparinize group, the AHA powder form was able to control the bleeding at 62.5% in the first minute and 37.5% in the second minute. Conclusion: This study shows that AHA is a highly effective and promising hemostatic agent in bleeding control.

Anahtar Kelime:

Ratlarda Femoral Arter Kanama Modelinde Bitki Bazlı Algan Hemostatik Ajanın Etkinliğinin Araştırılması

Öz:

Amaç: Bu çalışmanın amacı, sıçanlarda femoral arter insizyon modelinde üç farklı fiziksel formda (sıvı, toz ve spança emdirilmiş) bulunan Algan Hemostatik Ajanın (AHA) etkinliğini değerlendirmektir. Yöntemler: Çalışmada toplam 64 adet 5-7 haftalık rat kullanıldı. Ratlar rastgele olarak her biri sekiz rattan oluşan 4 gruba (4 grup heparinize ve 4 grup nonheparinize) ayrıldı. Deneysel femoral arter insizyonu oluşturuldu. Kontrol olarak serum fizyolojik emdirilmiş spanç uygulandı. Deney gruplarına AHA sıvısı, AHA tozu ve AHA sıvısı emdirilmiş spanç formları uygulandı. Bulgular: Kanama bölgelerine uygulanan tüm AHA formları kontrol grubuna göre anlamlı olarak daha kısa sürede kanamayı durdurdu (p<0.05). Buna karşılık, kontrol grubunda kanama 4 dakika içinde kontrol edilemedi. En iyi sonuç AHA toz formundaydı ve heparinize olmayan grupta kanamayı birinci dakikada %87,5 ve ikinci dakikada %12,5 oranında kontrol edebildi. Heparinize grupta AHA toz formu birinci dakikada %62,5, ikinci dakikada ise %37,5 oranında kanamayı kontrol edebildi. Sonuç: Bu çalışma, AHA'nın kanama kontrolünde oldukça etkili ve umut verici bir hemostatik ajan olduğunu göstermektedir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ekici H, KUMANDAS A, Ozbaykus A, Dizdaroglu H, Midi A, balık m, Yesilada E (2022). Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. , 88 - 95. 10.14235/bas.galenos.2021.5544
Chicago	Ekici Hüsamettin,KUMANDAS ALI,Ozbaykus Abdullah Canberk,Dizdaroglu Hazal,Midi Ahmet,balık mehmet sabri,Yesilada Erdem Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. (2022): 88 - 95. 10.14235/bas.galenos.2021.5544
MLA	Ekici Hüsamettin,KUMANDAS ALI,Ozbaykus Abdullah Canberk,Dizdaroglu Hazal,Midi Ahmet,balık mehmet sabri,Yesilada Erdem Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. , 2022, ss.88 - 95. 10.14235/bas.galenos.2021.5544
AMA	Ekici H,KUMANDAS A,Ozbaykus A,Dizdaroglu H,Midi A,balık m,Yesilada E Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. . 2022; 88 - 95. 10.14235/bas.galenos.2021.5544
Vancouver	Ekici H,KUMANDAS A,Ozbaykus A,Dizdaroglu H,Midi A,balık m,Yesilada E Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. . 2022; 88 - 95. 10.14235/bas.galenos.2021.5544
IEEE	Ekici H,KUMANDAS A,Ozbaykus A,Dizdaroglu H,Midi A,balık m,Yesilada E "Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding." , ss.88 - 95, 2022. 10.14235/bas.galenos.2021.5544
ISNAD	Ekici, Hüsamettin vd. "Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding". (2022), 88-95. https://doi.org/10.14235/bas.galenos.2021.5544

APA	Ekici H, KUMANDAS A, Ozbaykus A, Dizdaroglu H, Midi A, balık m, Yesilada E (2022). Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. Bezmiâlem Science, 10(1), 88 - 95. 10.14235/bas.galenos.2021.5544
Chicago	Ekici Hüsamettin,KUMANDAS ALI,Ozbaykus Abdullah Canberk,Dizdaroglu Hazal,Midi Ahmet,balık mehmet sabri,Yesilada Erdem Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. Bezmiâlem Science 10, no.1 (2022): 88 - 95. 10.14235/bas.galenos.2021.5544
MLA	Ekici Hüsamettin,KUMANDAS ALI,Ozbaykus Abdullah Canberk,Dizdaroglu Hazal,Midi Ahmet,balık mehmet sabri,Yesilada Erdem Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. Bezmiâlem Science, vol.10, no.1, 2022, ss.88 - 95. 10.14235/bas.galenos.2021.5544
AMA	Ekici H,KUMANDAS A,Ozbaykus A,Dizdaroglu H,Midi A,balık m,Yesilada E Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. Bezmiâlem Science. 2022; 10(1): 88 - 95. 10.14235/bas.galenos.2021.5544
Vancouver	Ekici H,KUMANDAS A,Ozbaykus A,Dizdaroglu H,Midi A,balık m,Yesilada E Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding. Bezmiâlem Science. 2022; 10(1): 88 - 95. 10.14235/bas.galenos.2021.5544
IEEE	Ekici H,KUMANDAS A,Ozbaykus A,Dizdaroglu H,Midi A,balık m,Yesilada E "Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding." Bezmiâlem Science, 10, ss.88 - 95, 2022. 10.14235/bas.galenos.2021.5544
ISNAD	Ekici, Hüsamettin vd. "Investigation of The Effectiveness of Plant Based Algan Hemostatic Agent in a Rat Model of Femoral Arterial Bleeding". Bezmiâlem Science 10/1 (2022), 88-95. https://doi.org/10.14235/bas.galenos.2021.5544