Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye

gök, koray; kul, gizem; ESIM BÜYÜKBAYRAK, ESRA; AKALIN, MÜNİP; KARA, Merve; Akalın, Emine Eda

doi:10.14744/zkmj.2022.24865

Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye

Münip AKALIN, (Perinatoloji Anabilim Dalı, Marmara Üniversite Pendik Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

Merve KARA, (Kadın Hastalıkları Bölümü ve Jinekoloji, Marmara Üniversitesi Pendik Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

Emine Eda AKALIN, (Kadın Hastalıkları Bölümü ve Jinekoloji, Bahçeşehir Üniversitesi Tıp Fakültesi, İstanbul, Türkiye)

Koray GÖK, (Perinatoloji Anabilim Dalı, Marmara Üniversite Pendik Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

Gizem KUL, (Perinatoloji Anabilim Dalı, Marmara Üniversite Pendik Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

Esra Esim BÜYÜKBAYRAK (Perinatoloji Anabilim Dalı, Marmara Üniversite Pendik Eğitim ve Araştırma Hastanesi, İstanbul, Türkiye)

Zeynep Kamil medical journal (Online)

12 0

Yıl: 2022 Cilt: 53 Sayı: 4 Sayfa Aralığı: 207 - 212 Metin Dili: İngilizce DOI: 10.14744/zkmj.2022.24865 İndeks Tarihi: 15-05-2023

Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye

Öz:

Objective: The aim of this study was to determine the reference ranges of second trimester nasal bone length (NBL), pre-nasal thickness (PT), and PT/NBL ratios of low- risk pregnant women in Turkish population. Material and Methods: Pregnant women of 16–28th gestational age who underwent ultrasonographic fetal screening between November 2021 and June 2022 were ret- rospectively analyzed. Fetuses with congenital malformations, high risk in antenatal screening tests, diagnosed with aneuploidy, and pregnant women of non-Turkish ethnic origin were excluded from the study. Fetuses were classified as ≤19+6 weeks, 20+0–20+6 weeks, 21+0–21+6 weeks, 22+0–22+6 weeks, 23+0–23+6 weeks, and ≥24+0 weeks. NBL, PT, and PT/NBL ratio was evaluated for each gestational age separately. Results: A total of 242 fetuses were included in the study. The mean NBL and mean PT increased with gestational age (6.42±0.65 at 20+0–20+6 weeks versus 7.65±0.79 at 23+0–23+6 weeks and 3.10±0.62 at 20+0–20+6 weeks vs. 3.55±0.63 at 23+0–23+6 weeks, respectively). Both NBL and PT were positively correlated with gestational age whereas the PT/NBL ratio was constant throughout the second trimester (PCC=0.81, p<0.001, PCC=0.56, p<0.001, and PCC=−0.07, p=0.255, respectively). The mean PT/NBL ratio in the second trimester was calculated as 0.46 (95% CI, 0.45–0.47, 5th p=0.35 and 95th p=0.62). Conclusion: The reference ranges for NBL, PT, and PT/NBL ratio may vary in differ- ent populations. Therefore, the use of population-specific nomograms may lead to higher success rates in Down syndrome screening.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	AKALIN M, KARA M, Akalın E, gök k, kul g, ESIM BÜYÜKBAYRAK E (2022). Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye. , 207 - 212. 10.14744/zkmj.2022.24865
Chicago	AKALIN MÜNİP,KARA Merve,Akalın Emine Eda,gök koray,kul gizem,ESIM BÜYÜKBAYRAK ESRA Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye. (2022): 207 - 212. 10.14744/zkmj.2022.24865
MLA	AKALIN MÜNİP,KARA Merve,Akalın Emine Eda,gök koray,kul gizem,ESIM BÜYÜKBAYRAK ESRA Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye. , 2022, ss.207 - 212. 10.14744/zkmj.2022.24865
AMA	AKALIN M,KARA M,Akalın E,gök k,kul g,ESIM BÜYÜKBAYRAK E Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye. . 2022; 207 - 212. 10.14744/zkmj.2022.24865
Vancouver	AKALIN M,KARA M,Akalın E,gök k,kul g,ESIM BÜYÜKBAYRAK E Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye. . 2022; 207 - 212. 10.14744/zkmj.2022.24865
IEEE	AKALIN M,KARA M,Akalın E,gök k,kul g,ESIM BÜYÜKBAYRAK E "Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye." , ss.207 - 212, 2022. 10.14744/zkmj.2022.24865
ISNAD	AKALIN, MÜNİP vd. "Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye". (2022), 207-212. https://doi.org/10.14744/zkmj.2022.24865

APA	AKALIN M, KARA M, Akalın E, gök k, kul g, ESIM BÜYÜKBAYRAK E (2022). Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye. Zeynep Kamil medical journal (Online), 53(4), 207 - 212. 10.14744/zkmj.2022.24865
Chicago	AKALIN MÜNİP,KARA Merve,Akalın Emine Eda,gök koray,kul gizem,ESIM BÜYÜKBAYRAK ESRA Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye. Zeynep Kamil medical journal (Online) 53, no.4 (2022): 207 - 212. 10.14744/zkmj.2022.24865
MLA	AKALIN MÜNİP,KARA Merve,Akalın Emine Eda,gök koray,kul gizem,ESIM BÜYÜKBAYRAK ESRA Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye. Zeynep Kamil medical journal (Online), vol.53, no.4, 2022, ss.207 - 212. 10.14744/zkmj.2022.24865
AMA	AKALIN M,KARA M,Akalın E,gök k,kul g,ESIM BÜYÜKBAYRAK E Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye. Zeynep Kamil medical journal (Online). 2022; 53(4): 207 - 212. 10.14744/zkmj.2022.24865
Vancouver	AKALIN M,KARA M,Akalın E,gök k,kul g,ESIM BÜYÜKBAYRAK E Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye. Zeynep Kamil medical journal (Online). 2022; 53(4): 207 - 212. 10.14744/zkmj.2022.24865
IEEE	AKALIN M,KARA M,Akalın E,gök k,kul g,ESIM BÜYÜKBAYRAK E "Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye." Zeynep Kamil medical journal (Online), 53, ss.207 - 212, 2022. 10.14744/zkmj.2022.24865
ISNAD	AKALIN, MÜNİP vd. "Reference ranges of nasal bone length, pre-nasal thickness, and pre-nasal thickness-to-nasal bone length ratio in low-risk pregnant women: A retrospective and cohort study from Türkiye". Zeynep Kamil medical journal (Online) 53/4 (2022), 207-212. https://doi.org/10.14744/zkmj.2022.24865