The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris
Yıl: 2022 Cilt: 50 Sayı: 8 Sayfa Aralığı: 583 - 589 Metin Dili: İngilizce DOI: 10.5543/tkda.2022.22412 İndeks Tarihi: 16-05-2023
The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris
Öz: Objective: Coronary artery calcification is a cornerstone marker for coronary atherosclerosis. Therefore, the calculation of the coronary artery calcium score has become a routine method in diagnosing coronary artery disease in recent years. Monocyte to high-density lipoprotein cholesterol ratio reflects proatherogenic and antiatherogenic balance, and this ratio is associated with coronary atherosclerosis and cardiovascular events. This study aimed to investigate the value of monocyte to high- densi tylip oprot ein cholesterol ratio in predicting coronary atherosclerosis, which coronary artery calcium score determines. Methods: A total of 276 patients with chest pain who underwent coronary computed tomography angiography were enrolled in the study. The patients were divided into 3 groups according to coronary artery calcium score [coronary artery calcium score = 0 for very low risk (n = 121), coronary artery calcium score = 1-99 for low risk (n = 100), coronary artery calcium score ≥ 100 for moderate-high risk (n = 55)]. The monocyte to high-density lipoprotein cholesterol ratio, neutr ophil -to-l ympho cyte ratio, systemic immune-inflammation index, and plate letto- lym phocy te ratio were calculated from venous blood samples. Results: Monocyte to high-density lipoprotein cholesterol ratio values were significantly higher in patients with moderate-high coronary artery calcium score (1.29 ± 0.59 vs 1.41 ± 0.56 vs 1.56 ± 0.58, P = .009). However, there were no differences between the groups in terms of other inflammatory markers (neut rophi l-to- lymph ocyte ratio, systemic immune-inflammation index, and plate let-t o-lym phocy te ratio). Age (odds ratio: 1.178; 95% CI: 1.107-1.253; P < .001), dyslipidemia (odds ratio: 14.252; 95% CI: 5.459-37.211; P < .001), smoking (odds ratio: 2.893; 95% CI: 1.317-6.358; P = .008), and monocyte to high-density lipoprotein cholesterol ratio (odds ratio: 2.082 per 1-point increase; 95% CI: 1.016-4.268; P = .045) were independent predictors of coronary artery calcium score in multivariate analysis. Conclusion: Our data showed that high monocyte to high-density lipoprotein cholesterol ratio is significantly associated with increased coronary artery calcium score. Monocyte to highdensity lipoprotein cholesterol ratio indicates that it can be applied easily and swiftly in clinics to help predicting the coronary artery disease.
Anahtar Kelime: Stabil Angina Pektorisli Hastalarda Koroner Arter Kalsiyum Skoru ile Monosit/Yüksek-Yoğunluklu Lipoprotein Kolesterol Oranı Arasındaki İlişki
Öz: Amaç: Koroner arter kalsifikasyonu, koroner ateroskleroz için önemli bir belirteçtir. Bu nedenle koroner arter kalsiyum skorunun (CCS) hesaplanması son yıllarda koroner arter hastalığı tanısında rutin bir yöntem haline gelmiştir. Monosit/yüksek yoğunluklu lipoprotein kolesterol oranı (MHR), proaterojenik ve antiaterojenik dengeyi yansıtır ve bu oran koroner ateroskleroz ve kardiyovasküler olaylarla ilişkilidir. Bu çalışma, CCS’nin belirlediği koroner aterosklerozu öngörmede MHR’nin değerini araştırmayı amaçladı. Yöntemler: Koroner BT anjiyografisi yapılan göğüs ağrısı olan toplam 276 hasta çalışmaya alındı. Hastalar CCS’ye göre [CCS = 0 çok düşük risk (n: 121), CCS = 1-99 düşük risk (n: 100), CCS ≥ 100 orta-yüksek risk (n: 55) olarak] üç gruba ayrıldı. Venöz kan örneklerinden MHR, nötrofil- lenfosit oranı (NLR), sistemik immün-enflamasyon indeksi (SII) ve trombosit-lenfosit oranı (PLR) hesaplandı. Bulgular: MHR değerleri orta-yüksek CCS’li hastalarda anlamlı olarak daha yüksekti (1,29 ± 0,59’a karşı 1,41 ± 0,56’ya karşı 1,56 ± 0,58, P = ,009). Ancak diğer enflamatuvar belirteçler (SII, NLR, PLR) açısından gruplar arasında fark yoktu. Yaş (OR: 1,178; %95 CI: 1,107-1,253; P <.001), dislipidemi (OR: 14,252; %95 CI: 5,459-37.211; P < ,001), sigara (OR: 2,893; %95 CI: 1,317-6,358; P = ,008) ve MHR (OR: 1 puanlık artış başına 2,082; %95 CI: 1,016-4,268; P = ,045), çok değişkenli analizde CCS’nin bağımsız öngörücüleriydi. Sonuç: Verilerimiz, yüksek MHR’nin artan CCS ile önemli ölçüde ilişkili olduğunu göstermektedir. MHR, koroner arter hastalığının öngörülmesine yardımcı olmak için kliniklerde kolay ve hızlı bir şekilde uygulanabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | celik a, bezgin t, KARAASLAN M, çoşkun r, Çağdaş M (2022). The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris. , 583 - 589. 10.5543/tkda.2022.22412 |
| Chicago | celik aziz inan,bezgin tahir,KARAASLAN MUHAMMET BUGRA,çoşkun reşit,Çağdaş Metin The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris. (2022): 583 - 589. 10.5543/tkda.2022.22412 |
| MLA | celik aziz inan,bezgin tahir,KARAASLAN MUHAMMET BUGRA,çoşkun reşit,Çağdaş Metin The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris. , 2022, ss.583 - 589. 10.5543/tkda.2022.22412 |
| AMA | celik a,bezgin t,KARAASLAN M,çoşkun r,Çağdaş M The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris. . 2022; 583 - 589. 10.5543/tkda.2022.22412 |
| Vancouver | celik a,bezgin t,KARAASLAN M,çoşkun r,Çağdaş M The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris. . 2022; 583 - 589. 10.5543/tkda.2022.22412 |
| IEEE | celik a,bezgin t,KARAASLAN M,çoşkun r,Çağdaş M "The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris." , ss.583 - 589, 2022. 10.5543/tkda.2022.22412 |
| ISNAD | celik, aziz inan vd. "The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris". (2022), 583-589. https://doi.org/10.5543/tkda.2022.22412 |
| APA | celik a, bezgin t, KARAASLAN M, çoşkun r, Çağdaş M (2022). The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris. Türk Kardiyoloji Derneği Arşivi, 50(8), 583 - 589. 10.5543/tkda.2022.22412 |
| Chicago | celik aziz inan,bezgin tahir,KARAASLAN MUHAMMET BUGRA,çoşkun reşit,Çağdaş Metin The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris. Türk Kardiyoloji Derneği Arşivi 50, no.8 (2022): 583 - 589. 10.5543/tkda.2022.22412 |
| MLA | celik aziz inan,bezgin tahir,KARAASLAN MUHAMMET BUGRA,çoşkun reşit,Çağdaş Metin The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris. Türk Kardiyoloji Derneği Arşivi, vol.50, no.8, 2022, ss.583 - 589. 10.5543/tkda.2022.22412 |
| AMA | celik a,bezgin t,KARAASLAN M,çoşkun r,Çağdaş M The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris. Türk Kardiyoloji Derneği Arşivi. 2022; 50(8): 583 - 589. 10.5543/tkda.2022.22412 |
| Vancouver | celik a,bezgin t,KARAASLAN M,çoşkun r,Çağdaş M The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris. Türk Kardiyoloji Derneği Arşivi. 2022; 50(8): 583 - 589. 10.5543/tkda.2022.22412 |
| IEEE | celik a,bezgin t,KARAASLAN M,çoşkun r,Çağdaş M "The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris." Türk Kardiyoloji Derneği Arşivi, 50, ss.583 - 589, 2022. 10.5543/tkda.2022.22412 |
| ISNAD | celik, aziz inan vd. "The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris". Türk Kardiyoloji Derneği Arşivi 50/8 (2022), 583-589. https://doi.org/10.5543/tkda.2022.22412 |
