TY  - JOUR
TI  - The Relationship between Coronary Artery Calcium Score and Monocyte to High-Density Lipoprotein Cholesterol Ratio in Patients with Stable Angina Pectoris
AB  - Objective: Coronary artery calcification is a cornerstone marker for coronary atherosclerosis. Therefore, the calculation of the coronary artery calcium score has become a routine method in diagnosing coronary artery disease in recent years. Monocyte to high-density lipoprotein cholesterol ratio reflects proatherogenic and antiatherogenic balance, and this ratio is associated with coronary atherosclerosis and cardiovascular events. This study aimed to investigate the value of monocyte to high- densi tylip oprot ein cholesterol ratio in predicting coronary atherosclerosis, which coronary artery calcium score determines. Methods: A total of 276 patients with chest pain who underwent coronary computed tomography angiography were enrolled in the study. The patients were divided into 3 groups according to coronary artery calcium score [coronary artery calcium score = 0 for very low risk (n = 121), coronary artery calcium score = 1-99 for low risk (n = 100), coronary artery calcium score ≥ 100 for moderate-high risk (n = 55)]. The monocyte to high-density lipoprotein cholesterol ratio, neutr ophil -to-l ympho cyte ratio, systemic immune-inflammation index, and plate letto- lym phocy te ratio were calculated from venous blood samples. Results: Monocyte to high-density lipoprotein cholesterol ratio values were significantly higher in patients with moderate-high coronary artery calcium score (1.29 ± 0.59 vs 1.41 ± 0.56 vs 1.56 ± 0.58, P = .009). However, there were no differences between the groups in terms of other inflammatory markers (neut rophi l-to- lymph ocyte ratio, systemic immune-inflammation index, and plate let-t o-lym phocy te ratio). Age (odds ratio: 1.178; 95% CI: 1.107-1.253; P < .001), dyslipidemia (odds ratio: 14.252; 95% CI: 5.459-37.211; P < .001), smoking (odds ratio: 2.893; 95% CI: 1.317-6.358; P = .008), and monocyte to high-density lipoprotein cholesterol ratio (odds ratio: 2.082 per 1-point increase; 95% CI: 1.016-4.268; P = .045) were independent predictors of coronary artery calcium score in multivariate analysis. Conclusion: Our data showed that high monocyte to high-density lipoprotein cholesterol ratio is significantly associated with increased coronary artery calcium score. Monocyte to highdensity lipoprotein cholesterol ratio indicates that it can be applied easily and swiftly in clinics to help predicting the coronary artery disease.
AU  - celik, aziz inan
AU  - bezgin, tahir
AU  - KARAASLAN, MUHAMMET BUGRA
AU  - çoşkun, reşit
AU  - Çağdaş, Metin
DO  - 10.5543/tkda.2022.22412
PY  - 2022
JO  - Türk Kardiyoloji Derneği Arşivi
VL  - 50
IS  - 8
SN  - 1016-5169
SP  - 583
EP  - 589
DB  - TRDizin
UR  - http://search/yayin/detay/1171358
ER  -