Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats
Yıl: 2022 Cilt: 47 Sayı: 1 Sayfa Aralığı: 33 - 39 Metin Dili: İngilizce DOI: 10.1515/tjb-2021-0091 İndeks Tarihi: 17-05-2023
Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats
Öz: Objectives: This study was performed to investigate whether exercise and quercetin have an effect on muscle energy charge in the metabolic syndrome (MetS) model of rats. Methods: Male Sprague-Dawley rats consisting of Control, Fructose, Quercetin, Exercise, Fructose + Exercise, Fructose + Quercetin, Fructose + Quercetin + Exercise groups were randomly divided into seven groups, six rats in each group. Consequently, it was determined that the 20% fructose supplement for 10 weeks with drinking water let to metabolic syndrome in the animals depending on the increase of systolic blood pressure, serum triglyceride, serum insulin and high HOMA-IR scores. MetS criteria were successfully established by oral fructose administration. Results: ATP and AMP levels were higher in fructose and exercise groups, and ADP levels were lower. The energy charge increased in quercetin treated groups. We found that regular aerobic exercise and quercetin application might be beneficial in the fructose-mediated MetS in accordance with previous studies. However it was found that quercetin was more effective than exercise in muscle. Conclusions: Consequently, it is thought that the regular aerobic exercise alone is a preventive method for the MetS and also it can be used together with quercetin as a beneficial treatment.
Anahtar Kelime: [Ratların metabolik sendrom modelinde kas enerji yükü üzerine kuersetin ve egzersizin etkileri]
Öz: Amaç: Bu çalışma; ratların metabolik sendrom (MetS) modelinde, egzersiz ve kuersetin’in kas enerji yükü üzerine etkisi olup olmadığını araştırmak için yapılmıştır. Gereç ve Yöntem: 42 erkek Sprague-Dawley ratları rastgele yedi gruba ayrıldı (n = 7): Kontrol, Fruktoz, Kuersetin, Egzersiz, Fruktoz + Egzersiz, Fruktoz + Kuersetin, Fruktoz + Kuersetin + Egzersiz. Sonuç olarak, içme suyu ile 10 hafta süreyle % 20 fruktoz takviyesinin; sistolik kan basıncı, serum trigliserit, serum insülin ve yüksek HOMA-IR skorlarındaki artışa bağlı olarak hayvanlarda metabolik sendroma yol açtığı belirlendi. MetS kriterleri, oral fruktoz uygulamasıyla başarıyla oluşturulmuştur. Bulgular: ATP ve AMP düzeyleri fruktoz ve egzersiz gruplarında daha yüksek, ADP düzeyleri daha düşük bulundu. Kuersetin uygulaması gruplarda enerji yükü artırdı. Düzenli aerobik egzersiz ve kuersetin uygulamasının fruktoz aracılı MetS’de, önceki çalışmalarla uyumlu olarak faydalı olabileceğini bulduk. Ancak kuersetin’in kasta egzersizden daha etkili olduğu bulundu. Sonuç: Sonuç olarak, düzenli aerobik egzersizin tek başına MetS için önleyici bir yöntem olduğu ve ayrıca yararlı bir tedavi olarak kuersetin ile birlikte kullanılabileceği düşünülmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | er f, Çimen B, YILMAZ C, zorba e, TÜRKÖZKAN N (2022). Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats. , 33 - 39. 10.1515/tjb-2021-0091 |
| Chicago | er fatmanur,Çimen Behzat,YILMAZ CANAN,zorba erdal,TÜRKÖZKAN Nurten Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats. (2022): 33 - 39. 10.1515/tjb-2021-0091 |
| MLA | er fatmanur,Çimen Behzat,YILMAZ CANAN,zorba erdal,TÜRKÖZKAN Nurten Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats. , 2022, ss.33 - 39. 10.1515/tjb-2021-0091 |
| AMA | er f,Çimen B,YILMAZ C,zorba e,TÜRKÖZKAN N Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats. . 2022; 33 - 39. 10.1515/tjb-2021-0091 |
| Vancouver | er f,Çimen B,YILMAZ C,zorba e,TÜRKÖZKAN N Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats. . 2022; 33 - 39. 10.1515/tjb-2021-0091 |
| IEEE | er f,Çimen B,YILMAZ C,zorba e,TÜRKÖZKAN N "Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats." , ss.33 - 39, 2022. 10.1515/tjb-2021-0091 |
| ISNAD | er, fatmanur vd. "Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats". (2022), 33-39. https://doi.org/10.1515/tjb-2021-0091 |
| APA | er f, Çimen B, YILMAZ C, zorba e, TÜRKÖZKAN N (2022). Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats. Türk Biyokimya Dergisi, 47(1), 33 - 39. 10.1515/tjb-2021-0091 |
| Chicago | er fatmanur,Çimen Behzat,YILMAZ CANAN,zorba erdal,TÜRKÖZKAN Nurten Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats. Türk Biyokimya Dergisi 47, no.1 (2022): 33 - 39. 10.1515/tjb-2021-0091 |
| MLA | er fatmanur,Çimen Behzat,YILMAZ CANAN,zorba erdal,TÜRKÖZKAN Nurten Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats. Türk Biyokimya Dergisi, vol.47, no.1, 2022, ss.33 - 39. 10.1515/tjb-2021-0091 |
| AMA | er f,Çimen B,YILMAZ C,zorba e,TÜRKÖZKAN N Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats. Türk Biyokimya Dergisi. 2022; 47(1): 33 - 39. 10.1515/tjb-2021-0091 |
| Vancouver | er f,Çimen B,YILMAZ C,zorba e,TÜRKÖZKAN N Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats. Türk Biyokimya Dergisi. 2022; 47(1): 33 - 39. 10.1515/tjb-2021-0091 |
| IEEE | er f,Çimen B,YILMAZ C,zorba e,TÜRKÖZKAN N "Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats." Türk Biyokimya Dergisi, 47, ss.33 - 39, 2022. 10.1515/tjb-2021-0091 |
| ISNAD | er, fatmanur vd. "Effects of exercise and quercetin on muscle energy charge in metabolic syndrome model of rats". Türk Biyokimya Dergisi 47/1 (2022), 33-39. https://doi.org/10.1515/tjb-2021-0091 |
