Restless leg syndrome and sleep quality in granulomatosis with polyangiitis

Güven, Serdar Can; Akyüz Dağlı, Pınar; Armagan, Berkan; erden, abdulsamet; kucuksahin, orhan; KARACAOGLU, Selin; Omma, Ahmet

doi:10.4274/raed.galenos.2022.36035

Restless leg syndrome and sleep quality in granulomatosis with polyangiitis

Serdar Can GÜVEN, (Ankara Bilkent Şehir Hastanesi, Romatoloji Kliniği, Ankara, Türkiye)

Pınar AKYÜZ DAĞLI, (Ankara Bilkent Şehir Hastanesi, Romatoloji Kliniği, Ankara, Türkiye)

Selin KARACAOGLU, (Ankara Şehir Hastanesi, Dahiliye Kliniği, Ankara, Türkiye)

Berkan ARMAĞAN, (Ankara Bilkent Şehir Hastanesi, Romatoloji Kliniği, Ankara, Türkiye)

Abdulsamet ERDEN, (Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Anabilim Dalı, Ankara, Türkiye)

Orhan KÜÇÜKŞAHİN, (Ankara Yıldırım Beyazıt Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Romatoloji Anabilim Dalı, Ankara, Türkiye)

Ahmet OMMA (Sağlık Bilimleri Üniversitesi, Ankara Bilkent Şehir Hastanesi, Romatoloji Kliniği, Ankara, Türkiye)

Ulusal Romatoloji Dergisi

7 2

Yıl: 2022 Cilt: 14 Sayı: 3 Sayfa Aralığı: 124 - 130 Metin Dili: İngilizce DOI: 10.4274/raed.galenos.2022.36035 İndeks Tarihi: 19-05-2023

Restless leg syndrome and sleep quality in granulomatosis with polyangiitis

Öz:

Objective: We investigated the frequency and severity of restless leg syndrome (RLS) and sleep quality in granulomatosis with polyangiitis (GPA) patients. Methods: A cross-sectional study was conducted on GPA patients. A control group was formed from patients of similar age and gender. Demographic, clinic and laboratory data were recorded. In the GPA group, disease activity was evaluated with Birmingham Vasculitis Activity score for Wegener Granulomatosis, disease-related damage by vasculitis damage index (VDI), quality of life (QoL) was by health assessment questionnaire (HAQ). In both groups, RLS diagnosis was confirmed and severity was measured according to the International Restless Legs Study Group criteria. Sleep quality was evaluated by the Pittsburgh Sleep Quality index (PSQI), sleepiness the Epworth Sleepiness scale, level of depression by the Beck Depression index (BDI). Results: Out of total 55 GPA patients, 36 who could be reached and who agreed to participate and meet the inclusion criteria were enrolled. The control group comprised 35 subjects. Age and sex were similar between groups. The frequency of RLS was similar between groups (19.4% vs. 17.1%, p=0.802). RLS severity score was indifferent. PSQI and BDI scores were increased in GPA. When parameters in GPA patients with and without RLS were compared, no significant differences were observed except for the cardiovascular damage domain of VDI. RLS severity scores did not correlate with other parameters. PSQI scores had significantly correlated with HAQ and BDI. Conclusion: The frequency of RLS was not increased in GPA compared with controls. Sleep quality was impaired and was observed to be related to worse QoL and higher scores for depression.

Anahtar Kelime:

Granülomatöz polianjit hastalarında uyku kalitesi ve huzursuz bacak sendromu

Öz:

Amaç: Bu çalışmada, granülomatöz polianjit (GPA) hastalarında huzursuz bacak sendromu (HBS) sıklığının, şiddetinin ve uyku kalitesinin değerlendirilmesi amaçlanmıştır. Yöntem: Kliniğimizde takip edilen erişkin GPA hastaları kesitsel olarak çalışmaya dahil edildi. Benzer yaş ve cinsiyet özelliklerine sahip sağlıklı gönüllülerden bir kontrol grubu oluşturuldu. Demografik, klinik ve laboratuvar bilgileri kaydedildi. Hasta grubunda hastalık aktivite düzeyi Birmingham Vaskülit Aktivite skoru-Wegener Granülomatozu (BVAS/ WG), GPA ilişkili hasar vaskülit hasar indeksi (VHİ), yaşam kalitesi Sağlık Değerlendirme Anketi (SDA) ile skorlandı. Her iki grupta HBS tanısı ve şiddeti Uluslararası Huzursuz Bacak Sendromu Çalışma Grubu tanı ve hastalık şiddeti kriterlerine göre belirlendi. Uyku kalitesi, Pittsburgh Uyku Kalitesi indeksi (PUKİ), uykululuk hali Epworth Uykululuk skalası, depresyon düzeyi Beck Depresyon indeksi (BDİ) ile ölçüldü. Bulgular: Elli beş GPA hastasından ulaşılan, katılmayı kabul eden ve dışlama kriteri olmayan 36 hasta çalışmaya dahil edildi. Otuz beş sağlıklı gönüllüden kontrol grubu oluşturuldu. İki grup arasında yaş ve cinsiyet yönünden anlamlı fark saptanmadı. GPA grubunda HBS sıklığı %19,4 kontrol grubunda %17,1 olarak saptandı (p=0,802). HBS şiddet skorları iki grup arasında anlamlı olarak farklı değildi. PUKİ ve BDİ skorları GPA grubunda daha yüksekti. HBS olan ve olmayan GPA hastaları karşılaştırıldığında BVAS/WG, VHİ skorları benzerdi. VHİ alt gruplarına bakıldığında sadece kardiyovasküler hasar HBS grubunda anlamlı olarak daha fazlaydı. HBS şiddet skorları ile diğer parametreler arasında korelasyon saptanmazken, PUKİ ile BDİ ve SDA arasında anlamlı korelasyon saptandı. Sonuç: GPA hastalarında HBS sıklığı kontrol grubuna göre anlamlı artış göstermemekle beraber uyku kalitesi skorları GPA hastalarında daha kötü olarak izlendi, depresyon ve yaşam kalitesi bozukluğu ile ilişkili olduğu görüldü.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Güven S, Akyüz Dağlı P, KARACAOGLU S, Armagan B, erden a, kucuksahin o, Omma A (2022). Restless leg syndrome and sleep quality in granulomatosis with polyangiitis. , 124 - 130. 10.4274/raed.galenos.2022.36035
Chicago	Güven Serdar Can,Akyüz Dağlı Pınar,KARACAOGLU Selin,Armagan Berkan,erden abdulsamet,kucuksahin orhan,Omma Ahmet Restless leg syndrome and sleep quality in granulomatosis with polyangiitis. (2022): 124 - 130. 10.4274/raed.galenos.2022.36035
MLA	Güven Serdar Can,Akyüz Dağlı Pınar,KARACAOGLU Selin,Armagan Berkan,erden abdulsamet,kucuksahin orhan,Omma Ahmet Restless leg syndrome and sleep quality in granulomatosis with polyangiitis. , 2022, ss.124 - 130. 10.4274/raed.galenos.2022.36035
AMA	Güven S,Akyüz Dağlı P,KARACAOGLU S,Armagan B,erden a,kucuksahin o,Omma A Restless leg syndrome and sleep quality in granulomatosis with polyangiitis. . 2022; 124 - 130. 10.4274/raed.galenos.2022.36035
Vancouver	Güven S,Akyüz Dağlı P,KARACAOGLU S,Armagan B,erden a,kucuksahin o,Omma A Restless leg syndrome and sleep quality in granulomatosis with polyangiitis. . 2022; 124 - 130. 10.4274/raed.galenos.2022.36035
IEEE	Güven S,Akyüz Dağlı P,KARACAOGLU S,Armagan B,erden a,kucuksahin o,Omma A "Restless leg syndrome and sleep quality in granulomatosis with polyangiitis." , ss.124 - 130, 2022. 10.4274/raed.galenos.2022.36035
ISNAD	Güven, Serdar Can vd. "Restless leg syndrome and sleep quality in granulomatosis with polyangiitis". (2022), 124-130. https://doi.org/10.4274/raed.galenos.2022.36035

APA	Güven S, Akyüz Dağlı P, KARACAOGLU S, Armagan B, erden a, kucuksahin o, Omma A (2022). Restless leg syndrome and sleep quality in granulomatosis with polyangiitis. Ulusal Romatoloji Dergisi, 14(3), 124 - 130. 10.4274/raed.galenos.2022.36035
Chicago	Güven Serdar Can,Akyüz Dağlı Pınar,KARACAOGLU Selin,Armagan Berkan,erden abdulsamet,kucuksahin orhan,Omma Ahmet Restless leg syndrome and sleep quality in granulomatosis with polyangiitis. Ulusal Romatoloji Dergisi 14, no.3 (2022): 124 - 130. 10.4274/raed.galenos.2022.36035
MLA	Güven Serdar Can,Akyüz Dağlı Pınar,KARACAOGLU Selin,Armagan Berkan,erden abdulsamet,kucuksahin orhan,Omma Ahmet Restless leg syndrome and sleep quality in granulomatosis with polyangiitis. Ulusal Romatoloji Dergisi, vol.14, no.3, 2022, ss.124 - 130. 10.4274/raed.galenos.2022.36035
AMA	Güven S,Akyüz Dağlı P,KARACAOGLU S,Armagan B,erden a,kucuksahin o,Omma A Restless leg syndrome and sleep quality in granulomatosis with polyangiitis. Ulusal Romatoloji Dergisi. 2022; 14(3): 124 - 130. 10.4274/raed.galenos.2022.36035
Vancouver	Güven S,Akyüz Dağlı P,KARACAOGLU S,Armagan B,erden a,kucuksahin o,Omma A Restless leg syndrome and sleep quality in granulomatosis with polyangiitis. Ulusal Romatoloji Dergisi. 2022; 14(3): 124 - 130. 10.4274/raed.galenos.2022.36035
IEEE	Güven S,Akyüz Dağlı P,KARACAOGLU S,Armagan B,erden a,kucuksahin o,Omma A "Restless leg syndrome and sleep quality in granulomatosis with polyangiitis." Ulusal Romatoloji Dergisi, 14, ss.124 - 130, 2022. 10.4274/raed.galenos.2022.36035
ISNAD	Güven, Serdar Can vd. "Restless leg syndrome and sleep quality in granulomatosis with polyangiitis". Ulusal Romatoloji Dergisi 14/3 (2022), 124-130. https://doi.org/10.4274/raed.galenos.2022.36035