Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity
Yıl: 2022 Cilt: 14 Sayı: 3 Sayfa Aralığı: 146 - 149 Metin Dili: İngilizce DOI: 10.4274/raed.galenos.2022.87597 İndeks Tarihi: 19-05-2023
Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity
Öz: Tubulointerstitial nephritis and uveitis syndrome is a rarely seen multi-systemic disease with autoimmune features. Renal and ocular involvement generally occurs asynchronously therefore leads to late diagnosis. Renal manifestations generally precede ocular involvement. Eye disease is almost always of recurrent bilateral anterior uveitis. Renal disease is generally mild, self-limited and rarely requires immunosuppression. Definitive diagnosis is based on histopathological evaluation in the presence of clinical features and exclusion of masquerading disorders. Steroid is the most preferred first line agent, usually suggested for at least 3 to 6 months. Here, our objective with this case report is to attract attention to this uncommon entity in the rheumatology literature.
Anahtar Kelime: Tubulointerstisyel nefrit ve üveit (TİNU) sendromu; az bilinen bir olgu
Öz: Tubulointerstiyel nefrit ve üveit (TİNU) sendromu, otoimmün özellikler barındıran, nadir bir multisistemik hastalıktır. Renal ve göz tutulumu çoğunlukla aynı zaman diliminde ortaya çıkmaz, bu nedenle tanıda gecikmelere neden olur. Genellikle, böbrek tutulumu göz tutulumundan önce görülür. Göz tutulumu, hemen daima tekrarlayıcı ve bilateral anterior üveit şeklindedir. Renal tutulum sıklıkla kendini sınırlayıcıdır ve nadiren immünosüpresif tedavi ihtiyacı olmaktadır. Kesin tanı, klinik ve histopatolojik bulguların yanı sıra taklitçi hastalıkların dışlanması ile konur. Steroid en sık tercih edilen ajan olmakla beraber en az 3-6 ay kadar kullanımı önerilmektedir. Burada TİNU sendromu tanısı konan bir olgu ile romatoloji literatüründe bu hastalık ile ilişkili farkındalığı artırmayı amaçladık.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
- 1. Dobrin RS, Vernier RL, Fish AL. Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome. Am J Med 1975;59:325-33.
- 2. Mandeville JT, Levinson RD, Holland GN. The tubulointerstitial nephritis and uveitis syndrome. Surv Ophthalmol 2001;46:195-208.
- 3. Bodakçi E , Üsküdar Cansu D , Korkmaz C. Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome: A Case Report and Review of Literatüre. Osmangazi Tıp Dergisi 2019;41:187-91.
- 4. Clive DM, Vanguri VK. The Syndrome of Tubulointerstitial Nephritis With Uveitis (TINU). Am J Kidney Dis 2018;72:118-28.
- 5. Tsirouki T, Dastiridou A, Symeonidis C, et al. A Focus on the Epidemiology of Uveitis. Ocul Immunol Inflamm 2018;26:2-16.
- 6. Kump LI, Cervantes-Castañeda RA, Androudi SN, Foster CS. Analysis of pediatric uveitis cases at a tertiary referral center. Ophthalmology 2005;112:1287-92.
- 7. Kobayashi Y, Honda M, Yoshikawa N, Ito H. Acute tubulointerstitial nephritis in 21 Japanese children. Clin Nephrol 2000;54:191-7.
- 8. Legendre M, Devilliers H, Perard L, et al. Clinicopathologic characteristics, treatment, and outcomes of tubulointerstitial nephritis and uveitis syndrome in adults: A national retrospective strobe-compliant study. Medicine (Baltimore) 2016;95:e3964.
- 9. Saarela V, Nuutinen M, Ala-Houhala M, Arikoski P, Rönnholm K, Jahnukainen T. Tubulointerstitial nephritis and uveitis syndrome in children: a prospective multicenter study. Ophthalmology 2013;120:1476-81.
- 10. Jain R, Yadav D, Puranik N, Guleria R, Jin JO. Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments. J Clin Med 2020;9:1081.
- 11. Hettinga YM, Scheerlinck LM, Lilien MR, Rothova A, de Boer JH. The value of measuring urinary β2-microglobulin and serum creatinine for detecting tubulointerstitial nephritis and uveitis syndrome in young patients with uveitis. JAMA Ophthalmol 2015;133:140-5.
- 12. Suzuki K, Nakahata T, Tanaka H, Waga S. Repeat renal biopsy in tubulointerstitial nephritis and uveitis syndrome: report of a case. Nihon Jinzo Gakkai Shi 2003;45:445-8.
- 13. Dusek J, Urbanova I, Stejskal J, Seeman T, Vondrak K, Janda J. Tubulointerstitial nephritis and uveitis syndrome in a mother and her son. Pediatr Nephrol 2008;23:2091-3.
- 14. Tanaka H, Waga S, Nakahata T, et al. Tubulointerstitial nephritis and uveitis syndrome in two siblings. Tohoku J Exp Med 2001;194:71-4.
- 15. Cigni A, Soro G, Faedda R, et al. A case of adult-onset tubulointerstitial nephritis and uveitis (“TINU syndrome”) associated with sacroiliitis and Epstein-Barr virus infection with good spontaneous outcome. Am J Kidney Dis 2003;42:E4-E10.
- 16. Grefer J, Santer R, Ankermann T, Faul S, Nölle B, Eggert P. Tubulointerstitial nephritis and uveitis in association with Epstein-Barr virus infection. Pediatr Nephrol 1999;13:336-9.
- 17. Stupp R, Mihatsch MJ, Matter L, Streuli RA. Acute tubulo- interstitial nephritis with uveitis (TINU syndrome) in a patient with serologic evidence for Chlamydia infection. Klin Wochenschr 1990;68:971-5.
- 18. Abed L, Merouani A, Haddad E, Benoit G, Oligny LL, Sartelet H. Presence of autoantibodies against tubular and uveal cells in a patient with tubulointerstitial nephritis and uveitis (TINU) syndrome. Nephrol Dial Transplant 2008;23:1452-5.
- 19. Tan Y, Yu F, Qu Z, et al. Modified C-reactive protein might be a target autoantigen of TINU syndrome. Clin J Am Soc Nephrol 2011;6:93-100.
- 20. Joyce E, Glasner P, Ranganathan S, Swiatecka-Urban A. Tubulointerstitial nephritis: diagnosis, treatment, and monitoring. Pediatr Nephrol 2017;32:577-87.
- 21. Amaro D, Carreño E, Steeples LR, Oliveira-Ramos F, Marques- Neves C, Leal I. Tubulointerstitial nephritis and uveitis (TINU) syndrome: a review. Br J Ophthalmol 2020;104:742-7.
| APA | YILDIRIM R, Yasar Bilge N, KASIFOGLU T (2022). Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity. , 146 - 149. 10.4274/raed.galenos.2022.87597 |
| Chicago | YILDIRIM REŞİT,Yasar Bilge Nazife Sule,KASIFOGLU TIMUCIN Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity. (2022): 146 - 149. 10.4274/raed.galenos.2022.87597 |
| MLA | YILDIRIM REŞİT,Yasar Bilge Nazife Sule,KASIFOGLU TIMUCIN Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity. , 2022, ss.146 - 149. 10.4274/raed.galenos.2022.87597 |
| AMA | YILDIRIM R,Yasar Bilge N,KASIFOGLU T Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity. . 2022; 146 - 149. 10.4274/raed.galenos.2022.87597 |
| Vancouver | YILDIRIM R,Yasar Bilge N,KASIFOGLU T Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity. . 2022; 146 - 149. 10.4274/raed.galenos.2022.87597 |
| IEEE | YILDIRIM R,Yasar Bilge N,KASIFOGLU T "Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity." , ss.146 - 149, 2022. 10.4274/raed.galenos.2022.87597 |
| ISNAD | YILDIRIM, REŞİT vd. "Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity". (2022), 146-149. https://doi.org/10.4274/raed.galenos.2022.87597 |
| APA | YILDIRIM R, Yasar Bilge N, KASIFOGLU T (2022). Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity. Ulusal Romatoloji Dergisi, 14(3), 146 - 149. 10.4274/raed.galenos.2022.87597 |
| Chicago | YILDIRIM REŞİT,Yasar Bilge Nazife Sule,KASIFOGLU TIMUCIN Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity. Ulusal Romatoloji Dergisi 14, no.3 (2022): 146 - 149. 10.4274/raed.galenos.2022.87597 |
| MLA | YILDIRIM REŞİT,Yasar Bilge Nazife Sule,KASIFOGLU TIMUCIN Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity. Ulusal Romatoloji Dergisi, vol.14, no.3, 2022, ss.146 - 149. 10.4274/raed.galenos.2022.87597 |
| AMA | YILDIRIM R,Yasar Bilge N,KASIFOGLU T Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity. Ulusal Romatoloji Dergisi. 2022; 14(3): 146 - 149. 10.4274/raed.galenos.2022.87597 |
| Vancouver | YILDIRIM R,Yasar Bilge N,KASIFOGLU T Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity. Ulusal Romatoloji Dergisi. 2022; 14(3): 146 - 149. 10.4274/raed.galenos.2022.87597 |
| IEEE | YILDIRIM R,Yasar Bilge N,KASIFOGLU T "Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity." Ulusal Romatoloji Dergisi, 14, ss.146 - 149, 2022. 10.4274/raed.galenos.2022.87597 |
| ISNAD | YILDIRIM, REŞİT vd. "Tubulointerstitial nephritis and uveitis (TINU) syndrome; an underrecognized entity". Ulusal Romatoloji Dergisi 14/3 (2022), 146-149. https://doi.org/10.4274/raed.galenos.2022.87597 |
