Evaluation of Subclinical Inflammation in Children with Premature Adrenarche

DOĞAN, Halef Okan; Köylü, Gözde; ÇELİK, Nurullah

doi:10.14744/etd.2022.39699

Evaluation of Subclinical Inflammation in Children with Premature Adrenarche

Gözde KÖYLÜ, (Pediatri Bölümü, Cumhuriyet Üniversitesi Tıp Fakültesi, Sivas, Türkiye)

Nurullah ÇELİK, (Pediatri Bölümü Edokrinoloji, Anabilim Dalı Pediatri, Cumhuriyet Üniversitesi Tıp Fakültesi, Sivas, Türkiye)

Halef Okan DOĞAN (Biyokimya Bölümü, Cumhuriyet Üniversitesi Tıp Fakültesi, Sivas, Türkiye)

Erciyes Medical Journal

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Yıl: 2022 Cilt: 44 Sayı: 6 Sayfa Aralığı: 603 - 607 Metin Dili: İngilizce DOI: 10.14744/etd.2022.39699 İndeks Tarihi: 20-05-2023

Evaluation of Subclinical Inflammation in Children with Premature Adrenarche

Öz:

Objective: The objectives of this study were to compare the serum inflammatory markers, interleukin-6 (IL-6), highly sensi- tive C-reactive protein (hs-CRP), and fetuin-A, in patients with premature adrenarche (PA) and the control group. Materials and Methods: This single-center cross-sectional study included 85 non-obese and pre-pubertal children. After 8–12 h of fasting, blood glucose, HDL, LDL, triglyceride, cholesterol, insulin, dehydroepiandrosterone sulfate, total testos- terone, 17-OH PG, IL-6, hs-CRP, and Fetuin-A levels were measured and compared in a convenience sample of PA (n=35) and a healthy volunteers of control (n=50) group. Results: The mean age (7.34±0.62 years vs. 7.09±0.77 years, respectively) and sex (82% girl vs. 80% girl, respectively) of the PA and control groups were similar (p>0.05). Fasting insulin levels (10.9±6.21 Uu/mL vs. 7.4±5.9 Uu/mL; p<0.001), HOMA-IR (2.06±0.63 vs. 1.36±1.00; p=0.017), FGIR (11.31±5.60 vs. 16.46±8.52; p=0.004), and QUICKI (0.35±0.02 vs. 0.37±0.03; p<0.001) levels were different in PA and control groups. IL-6 level higher in PA group than controls [2.7 (3.30) pg/mL vs. 3.02 (1.31) pg/mL, p=0.035], while plasma Fetuin-A [522.02 (715.86) mg/L; 519.4 (945.97) mg/L, p=0.434] and hs-CRP [0.73 (1.02) mg/dL; 1.0 (1.12) mg/dL, p=0.439] levels were similar. IL-6 cutoff value for PA was calculated as 2.06 with 72.7% sensitivity and 48.8% specificity for all study groups (AUC=0.641, p=0.036). Conclusion: The high IL-6 levels may be an indicator of chronic subclinical inflammation in PA cases. These children should be followed closely in terms of metabolic disorders.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Köylü G, ÇELİK N, DOĞAN H (2022). Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. , 603 - 607. 10.14744/etd.2022.39699
Chicago	Köylü Gözde,ÇELİK Nurullah,DOĞAN Halef Okan Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. (2022): 603 - 607. 10.14744/etd.2022.39699
MLA	Köylü Gözde,ÇELİK Nurullah,DOĞAN Halef Okan Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. , 2022, ss.603 - 607. 10.14744/etd.2022.39699
AMA	Köylü G,ÇELİK N,DOĞAN H Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. . 2022; 603 - 607. 10.14744/etd.2022.39699
Vancouver	Köylü G,ÇELİK N,DOĞAN H Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. . 2022; 603 - 607. 10.14744/etd.2022.39699
IEEE	Köylü G,ÇELİK N,DOĞAN H "Evaluation of Subclinical Inflammation in Children with Premature Adrenarche." , ss.603 - 607, 2022. 10.14744/etd.2022.39699
ISNAD	Köylü, Gözde vd. "Evaluation of Subclinical Inflammation in Children with Premature Adrenarche". (2022), 603-607. https://doi.org/10.14744/etd.2022.39699

APA	Köylü G, ÇELİK N, DOĞAN H (2022). Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. Erciyes Medical Journal, 44(6), 603 - 607. 10.14744/etd.2022.39699
Chicago	Köylü Gözde,ÇELİK Nurullah,DOĞAN Halef Okan Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. Erciyes Medical Journal 44, no.6 (2022): 603 - 607. 10.14744/etd.2022.39699
MLA	Köylü Gözde,ÇELİK Nurullah,DOĞAN Halef Okan Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. Erciyes Medical Journal, vol.44, no.6, 2022, ss.603 - 607. 10.14744/etd.2022.39699
AMA	Köylü G,ÇELİK N,DOĞAN H Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. Erciyes Medical Journal. 2022; 44(6): 603 - 607. 10.14744/etd.2022.39699
Vancouver	Köylü G,ÇELİK N,DOĞAN H Evaluation of Subclinical Inflammation in Children with Premature Adrenarche. Erciyes Medical Journal. 2022; 44(6): 603 - 607. 10.14744/etd.2022.39699
IEEE	Köylü G,ÇELİK N,DOĞAN H "Evaluation of Subclinical Inflammation in Children with Premature Adrenarche." Erciyes Medical Journal, 44, ss.603 - 607, 2022. 10.14744/etd.2022.39699
ISNAD	Köylü, Gözde vd. "Evaluation of Subclinical Inflammation in Children with Premature Adrenarche". Erciyes Medical Journal 44/6 (2022), 603-607. https://doi.org/10.14744/etd.2022.39699