Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation

Vardi, Nigar; Parlakpinar, Hakan; GUNATA, MEHMET; Yıldız, Azibe; Ciftci, Tuba; POLAT, SEYHAN; temelli, öztun; POLAT, ALAADIN

Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation

Azibe YILDIZ, (İnönü Üniversitesi/Tıp Fakültesi Histoloji ve Embriyoloji Anabilim Dalı, Malatya, TÜRKİYE)

Tuba Ciftci, (İnönü Üniversitesi/Tıp Fakültesi, Tıp Öğrencisi, Malatya, TÜRKİYE)

Seyhan POLAT, (İnönü Üniversitesi/Tıp Fakültesi Tıbbi Farmakoloji Anabilim Dalı, Malatya, TÜRKİYE)

MEHMET GUNATA, (İnönü Üniversitesi/Tıp Fakültesi Tıbbi Farmakoloji Anabilim Dalı, Malatya, TÜRKİYE)

Hakan PARLAKPINAR, (İnönü Üniversitesi/Tıp Fakültesi Tıbbi Farmakoloji Anabilim Dalı, Malatya, TÜRKİYE)

Öztun TEMELLİ, (İnönü Üniversitesi/Tıp Fakültesi Radyasyon Onkolojisi Anabilim Dalı, Malatya, TÜRKİYE)

Alaadin POLAT, (İnönü Üniversitesi/ Tıp Fakültesi Fizyoloji Anabilim Dalı, Malatya, TÜRKİYE)

Nigar VARDI (İnönü Üniversitesi/Tıp Fakültesi Histoloji ve Embriyoloji Anabilim Dalı, Malatya, TÜRKİYE)

Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi

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Yıl: 2022 Cilt: 36 Sayı: 3 Sayfa Aralığı: 79 - 84 Metin Dili: İngilizce İndeks Tarihi: 21-05-2023

Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation

Öz:

Objective: Damage in the central nervous system caused by cranial radiotherapy (RT) has been linked to neuroinflammation due to microglial activation. Evidence reveals that resveratrol (RES) exerts neuroprotective effects by inhibiting neuroinflammation. There are limited studies investigating the effects of RES on microglia-related neuroinflammation developed as a result of RT. Therefore, this study was designed to investigate the effects of RES on RT-induced microglial- related neuroinflammation. Materials and Methods: Rats were simple randomly divided into three groups. Sham (SH) group received ethanol solution on the 1st-14th days of the study. RT group was applied a single dose of total cranial 15 Gy X radiation on the 7th day of the study. RES group was administered a dose of 20 mg/kg on the 1st-14th days of the study and a single dose of total cranial 15 Gy X radiation on the 7th day of the study. The brain tissues removed at the end of the experiment were subjected to histological techniques and procedures for histological and immunohistochemical examinations. The data were evaluated statistically. Results: RT administration caused histological changes such as neuron degeneration and edema in the brain tissue. In addition, RT administration induced a significant increase in CD68 and tumor necrosis factor-alpha (TNF-α) immunoreactivity. In the RES+RT group, it was observed that histological changes were alleviated, and CD68 and TNF-α immunoreactivities were decreased. In addition, a significant increase in the immunoreactivity of autophagy-related proteins was detected in this group. Conclusion: Evaluating together all the data, it was revealed that RES attenuates microglia- mediated neuroinflammation and neuronal degeneration.

Anahtar Kelime: Radiotherapy resveratrol neuroinflammation microglia autophagy

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Yıldız A, Ciftci T, POLAT S, GUNATA M, Parlakpinar H, temelli ö, POLAT A, Vardi N (2022). Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation. , 79 - 84.
Chicago	Yıldız Azibe,Ciftci Tuba,POLAT SEYHAN,GUNATA MEHMET,Parlakpinar Hakan,temelli öztun,POLAT ALAADIN,Vardi Nigar Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation. (2022): 79 - 84.
MLA	Yıldız Azibe,Ciftci Tuba,POLAT SEYHAN,GUNATA MEHMET,Parlakpinar Hakan,temelli öztun,POLAT ALAADIN,Vardi Nigar Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation. , 2022, ss.79 - 84.
AMA	Yıldız A,Ciftci T,POLAT S,GUNATA M,Parlakpinar H,temelli ö,POLAT A,Vardi N Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation. . 2022; 79 - 84.
Vancouver	Yıldız A,Ciftci T,POLAT S,GUNATA M,Parlakpinar H,temelli ö,POLAT A,Vardi N Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation. . 2022; 79 - 84.
IEEE	Yıldız A,Ciftci T,POLAT S,GUNATA M,Parlakpinar H,temelli ö,POLAT A,Vardi N "Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation." , ss.79 - 84, 2022.
ISNAD	Yıldız, Azibe vd. "Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation". (2022), 79-84.

APA	Yıldız A, Ciftci T, POLAT S, GUNATA M, Parlakpinar H, temelli ö, POLAT A, Vardi N (2022). Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, 36(3), 79 - 84.
Chicago	Yıldız Azibe,Ciftci Tuba,POLAT SEYHAN,GUNATA MEHMET,Parlakpinar Hakan,temelli öztun,POLAT ALAADIN,Vardi Nigar Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi 36, no.3 (2022): 79 - 84.
MLA	Yıldız Azibe,Ciftci Tuba,POLAT SEYHAN,GUNATA MEHMET,Parlakpinar Hakan,temelli öztun,POLAT ALAADIN,Vardi Nigar Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, vol.36, no.3, 2022, ss.79 - 84.
AMA	Yıldız A,Ciftci T,POLAT S,GUNATA M,Parlakpinar H,temelli ö,POLAT A,Vardi N Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi. 2022; 36(3): 79 - 84.
Vancouver	Yıldız A,Ciftci T,POLAT S,GUNATA M,Parlakpinar H,temelli ö,POLAT A,Vardi N Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation. Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi. 2022; 36(3): 79 - 84.
IEEE	Yıldız A,Ciftci T,POLAT S,GUNATA M,Parlakpinar H,temelli ö,POLAT A,Vardi N "Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation." Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi, 36, ss.79 - 84, 2022.
ISNAD	Yıldız, Azibe vd. "Anti-Inflammatory Effects of Resveratrol on the Radiotherapy-Induced Neuroinflammation". Fırat Üniversitesi Sağlık Bilimleri Tıp Dergisi 36/3 (2022), 79-84.