Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer
Yıl: 2023 Cilt: 34 Sayı: 2 Sayfa Aralığı: 45 - 51 Metin Dili: İngilizce DOI: 10.5152/tjg.2022.22203 İndeks Tarihi: 21-05-2023
Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer
Öz: Background: We aimed to investigate the effect of hemoglobin/prognostic nutritional index and hemoglobin/red blood cell distribution, which are indicators of inflammation and nutrition, on prognosis and survival in patients with rectal cancer. Methods: The retrospective study reviewed medical records of 138 patients with rectal cancer who were followed up between 2010 and 2021. The effects of hemoglobin/red blood cell distribution, hemoglobin/prognostic nutritional index, tumor stage, and lymph node sta- tus on survival and prognosis were evaluated using univariate and multivariate analyses. Overall survival and disease-free survival were calculated for both groups. Results: Survival and prognosis were found to be significantly better in nonanemic patients with the hemoglobin/prognostic nutritional index higher than the cut-off value than in anemic patients with a normal or lower hemoglobin/prognostic nutritional index. Similarly, survival and prognosis were found to be significantly better in nonanemic patients with a hemoglobin/red blood cell distribution higher than the cut-off value than in anemic patients with a normal or lower hemoglobin/red blood cell distribution. Conclusion: The results indicated that nutrition and inflammatory markers have independent prognostic significance in rectal cancer. These markers are simple, inexpensive, and useful biomarkers commonly used in clinical practice, and they were found to predict overall survival and disease-free survival independently.
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- Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7-34. [CrossRef]
- Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209-249. [CrossRef]
- Wang L, Lo CH, He X, et al. Risk factor profiles differ for cancers of different regions of the colorectum. Gastroenterology. 2020; 159(1):241-256.e13. [CrossRef]
- Diakos CI, Charles KA, McMillan DC, Clarke SJ. Cancer-related inflammation and treatment effectiveness. Lancet Oncol. 2014; 15(11):e493-e503. [CrossRef]
- Li MX, Liu XM, Zhang XF, et al. Prognostic role of neutrophil -tolymphocyte ratio in colorectal cancer: a systematic review and metaanalysis. Int J Cancer. 2014;134(10):2403-2413. [CrossRef]
- Song W, Wang K, Zhang RJ, Zou SB. Prognostic value of the lym- phocyte monocyte ratio in patients with colorectal cancer: a meta- analysis.Medicine. 2016;95(49):e5540. [CrossRef]
- Mohri Y, Inoue Y, Tanaka K, Hiro J, Uchida K, Kusunoki M. Prognos- tic nutritional index predicts postoperative outcome in colorectal cancer. World J Surg. 2013;37(11):2688-2692. [CrossRef]
- Migita K, Takayama T, Saeki K, et al. The prognostic nutritional index predicts longterm outcomes of gastric cancer patients inde- pendent of tumor stage. Ann Surg Oncol. 2013;20(8):2647-2654. [CrossRef]
- Kanda M, Fujii T, Kodera Y, Nagai S, Takeda S, Nakao A. Nutritional predictors of postoperative outcome in pancreatic cancer. Br J Surg. 2011;98(2):268-274. [CrossRef]
- Koma Y, Onishi A, Matsuoka H, et al. Increased red blood cell distribution width associates with cancer stage and prognosis in patients with lung cancer. PLoS One. 2013;8(11):e80240. [CrossRef]
- Nozoe T, Kohno M, Iguchi T, et al. The prognostic nutritional index can be a prognostic indicator in colorectal carcinoma. Surg Today. 2012;42(6):532-535. [CrossRef]
- Suzuki Y, Okabayashi K, Hasegawa H, et al. Comparison of pre- operative inflammation-based prognostic scores in patients with colorectal cancer. Ann Surg. 2018;267(3):527-531. [CrossRef]
- . McMillan DC. Systemic inflammation, nutritional status and sur- vival in patients with cancer. Curr Opin Clin Nutr Metab Care. 2009;12(3):223-226. [CrossRef]
- Terzić J, Grivennikov S, Karin E, Karin M. Inflammation and colon cancer. Gastroenterology. 2010;138(6):2101-2114.e5. [CrossRef]
- Ye X, Liu J, Chen Y, Wang N, Lu R. The impact of hemoglobin level and transfusion on the outcomes of chemotherapy in gastric cancer patients. Int J Clin Exp Med. 2015;8(3):4228-4235.
- Diefenhardt M, Hofheinz RD, Martin D, et al. Leukocytosis and neutrophilia as independent prognostic immunological biomarkers for clinical outcome in the CAO/ARO/AIO-04 randomized phase 3 rectal cancer trial. Int J Cancer. 2019;145(8):2282-2291. [CrossRef]
- 1 Russo A, Russano M, Franchina T, et al. Prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors. Adv Ther. 2020;37(3):1145-1155. [CrossRef]
- Cetinkaya E, Senol K, Saylam B, Tez M. Red cell distribution width to platelet ratio: new and promising prognostic marker in acute pan- creatitis. World J Gastroenterol. 2014;20(39):14450-14454. [CrossRef]
- Yeşil A, Senateş E, Bayoğlu IV , Erdem ED, Demirtunç R, Kurdaş Övünç AO. Red cell distribution width: a novel marker of activity in inflammatory bowel disease. Gut Liver. 2011;5(4):460-467. [CrossRef]
- Xu WS, Qiu XM, Ou QS, et al. Red blood cell distribution width levels correlate with liver fibrosis and inflammation: a noninvasive serum marker panel to predict the severity of fibrosis and inflamma- tion in patients with hepatitis B. Medicine. 2015;94(10):article e612. [CrossRef]
- Agarwal S. Red cell distribution width, inflammatory markers and cardiorespiratory fitness: results from the National Health and Nutri- tion Examination Survey. Indian Heart J. 2012;64(4):380-387. [CrossRef]
- Warwick R, Mediratta N, Shackcloth M, Shaw M, McShane J, Poullis M. Preoperative red cell distribution width in patients under- going pulmonary resections for nonsmall- cell lung cancer. Eur J Cardiothorac Surg. 2014;45(1):108-113. [CrossRef]
- Zhai Z, Gao J, Zhu Z, et al. The ratio of the hemoglobin to red cell distribution width combined with the ratio of platelets to lym- phocytes can predict the survival of patients with gastric cancer liver metastasis’. BioMed Res Int. 2021;2021:Article ID 8729869. [CrossRef]
- Chen JL, Wu JN, Lv XD, et al. The value of red blood cell distribu- tion width, neutrophil-to-lymphocyte ratio, and hemoglobin-to-red blood cell distribution width ratio in the progression of non-small cell lung cancer. PLoS One. 2020;15(8):e0237947. [CrossRef]
- Sun P, Zhang F, Chen C, et al. The ratio of hemoglobin to red cell distribution width as a novel prognostic parameter in esophageal squamous cell carcinoma:a retrospective study from southern China. Oncotarget. 2016;7(27):42650-42660. [CrossRef] 26. Hong S, Zhou T, Fang W, et al. The prognostic nutritional index (PNI) predicts overall survival of small-cell lung cancer patients. Tumour Biol. 2015;36(5):3389-3397. [CrossRef]
- Ishizuka M, Oyama Y, Abe A, Tago K, Tanaka G, Kubota K. Prognostic nutritional index is associated with survival after total gastrectomy for patients with gastric cancer. Anticancer Res. 2014;34(8):4223-4229.
- Jian-hui C, Iskandar EA, Cai ShI, et al., Significance of Onodera’s prognostic nutritional index in patients with colorectal cancer: a large cohort study in a single Chinese institution. Tumour Biol. 2016;37(3):3277-3283. [CrossRef]
- Jiang N, Deng JY, Ding XW, et al. Prognostic nutritional index predicts postoperative complications and long-term outcomes of gastric cancer. World J Gastroenterol. 2014;20(30):10537-10544. [CrossRef]
- Wang B, Jiang XW, Tian DL, Zhou N, Geng W. Combination of haemoglobin and prognostic nutritional index predicts the prognosis of postoperative radiotherapy for esophageal squamous cell carci- noma. Cancer Manag Res. 2020;12:8589-8597. [CrossRef]
| APA | Tuncel E, Parvizi M, kut e, AYDIN M, KAYA R (2023). Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer. , 45 - 51. 10.5152/tjg.2022.22203 |
| Chicago | Tuncel Elif Tugba,Parvizi Murtaza,kut engin,AYDIN MESUT,KAYA RESMİYE Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer. (2023): 45 - 51. 10.5152/tjg.2022.22203 |
| MLA | Tuncel Elif Tugba,Parvizi Murtaza,kut engin,AYDIN MESUT,KAYA RESMİYE Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer. , 2023, ss.45 - 51. 10.5152/tjg.2022.22203 |
| AMA | Tuncel E,Parvizi M,kut e,AYDIN M,KAYA R Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer. . 2023; 45 - 51. 10.5152/tjg.2022.22203 |
| Vancouver | Tuncel E,Parvizi M,kut e,AYDIN M,KAYA R Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer. . 2023; 45 - 51. 10.5152/tjg.2022.22203 |
| IEEE | Tuncel E,Parvizi M,kut e,AYDIN M,KAYA R "Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer." , ss.45 - 51, 2023. 10.5152/tjg.2022.22203 |
| ISNAD | Tuncel, Elif Tugba vd. "Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer". (2023), 45-51. https://doi.org/10.5152/tjg.2022.22203 |
| APA | Tuncel E, Parvizi M, kut e, AYDIN M, KAYA R (2023). Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer. Turkish Journal of Gastroenterology, 34(2), 45 - 51. 10.5152/tjg.2022.22203 |
| Chicago | Tuncel Elif Tugba,Parvizi Murtaza,kut engin,AYDIN MESUT,KAYA RESMİYE Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer. Turkish Journal of Gastroenterology 34, no.2 (2023): 45 - 51. 10.5152/tjg.2022.22203 |
| MLA | Tuncel Elif Tugba,Parvizi Murtaza,kut engin,AYDIN MESUT,KAYA RESMİYE Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer. Turkish Journal of Gastroenterology, vol.34, no.2, 2023, ss.45 - 51. 10.5152/tjg.2022.22203 |
| AMA | Tuncel E,Parvizi M,kut e,AYDIN M,KAYA R Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer. Turkish Journal of Gastroenterology. 2023; 34(2): 45 - 51. 10.5152/tjg.2022.22203 |
| Vancouver | Tuncel E,Parvizi M,kut e,AYDIN M,KAYA R Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer. Turkish Journal of Gastroenterology. 2023; 34(2): 45 - 51. 10.5152/tjg.2022.22203 |
| IEEE | Tuncel E,Parvizi M,kut e,AYDIN M,KAYA R "Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer." Turkish Journal of Gastroenterology, 34, ss.45 - 51, 2023. 10.5152/tjg.2022.22203 |
| ISNAD | Tuncel, Elif Tugba vd. "Prognostic Significance of Hemoglobin/Prognostic Nutritional Index and Hemoglobin/Red Blood Cell Distribution in Rectal Cancer". Turkish Journal of Gastroenterology 34/2 (2023), 45-51. https://doi.org/10.5152/tjg.2022.22203 |
