An Overview of Nanofiber Applications for Development of Phytopharmaceuticals

ABDO, Lüceyn; ESENTÜRK-GÜZEL, IMREN; Büyükkayhan, Derya; SINDHU, Rakesh K; ALGIN YAPAR, Evren; Esentürk, Engin

doi:10.14235/bas.galenos.2022.30502

An Overview of Nanofiber Applications for Development of Phytopharmaceuticals

IMREN ESENTÜRK, (Sağlık Bilimleri Üniversitesi, , Hamidiye Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, İstanbul, Türkiye)

Lüceyn ABDO, (Sağlık Bilimleri Üniversitesi, , Hamidiye Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, İstanbul, Türkiye)

Evren ALGIN YAPAR, (Sivas Cumhuriyet Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Sivas, Türkiye)

Engin ESENTÜRK, (İstanbul Kent Üniversitesi, Ağız ve Diş Sağlığı Eğitimi Uygulama ve Araştırma Merkezi, İstanbul, Türkiye)

Derya BÜYÜKKAYHAN, (Sağlık Bilimleri Üniversitesi, Haseki Eğitim ve Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, Neonatoloji Anabilim Dalı, İstanbul, Türkiye)

Rakesh K SINDHU (Sharda University, Sharda School of Pharmacy, Uttar Pradesh, India)

Bezmiâlem Science

9 5

Yıl: 2022 Cilt: 10 Sayı: 5 Sayfa Aralığı: 666 - 673 Metin Dili: İngilizce DOI: 10.14235/bas.galenos.2022.30502 İndeks Tarihi: 22-05-2023

An Overview of Nanofiber Applications for Development of Phytopharmaceuticals

Öz:

Herbal sources contain a variety of bio-actives, which are also called phytochemicals. Many of the herbal bio-actives have therapeutic effects and distinguished chemical properties that allow them favorable candidates for phytomedicines. The history of traditional herbal medicines, which are the precursors of phytopharmaceuticals, dates back to ancient times. Today, many of the officially approved and widely used medicines are produced by isolating active substances from herbal sources. Although traditional pharmaceutical dosage forms such as tablets, capsules, syrups, solutions, decoctions and ointments are still used today, problems related with the absorption, biotransformation and stability of phytochemicals reduces the efficacy, bioavailability and in some cases safety of herbal medicines. Also, conventional pharmaceutical dosage forms are often providing an immediate release of phytoconstituents. Besides the use of advanced drug delivery systems offer advantages to overcome mentioned problems, they also provide extended release with maximum efficacy associated with minimum side effects. Researches on development of herbal formulations by using novel drug delivery systems have gain attention and the use of nanotechnology-based systems have special attention. One of the nano drug carrier systems is nanofibers which have unique properties making them widely used in different treatments such as infections, allergy, rheumatic diseases, inflammatory diseases, cancers, etc. In this study, the use of the nanofiber-based carrier systems to deliver herbal bio-actives through various drug application routes is overviewed.

Anahtar Kelime:

Fitofarmasötiklerin Geliştirilmesi için Nanolif Uygulamalarına Genel Bir Bakış

Öz:

Bitkisel kaynaklar, fitokimyasallar olarak da adlandırılan çeşitli biyoaktif maddeler içerirler. Bitkisel biyo-aktiflerin çoğu, bitkisel ilaçlar için uygun aday olmalarını sağlayan terapötik etkilere ve kimyasal özelliklere sahiptirler. Fitofarmasötiklerin öncüsü olan geleneksel bitkisel ilaçların tarihi çok eskilere dayanmaktadır. Günümüzde resmi olarak onaylanmış ve yaygın olarak kullanılan ilaçların birçoğu bitkisel kaynaklardan etken maddelerin izole edilmesiyle üretilmektedir. Tabletler, kapsüller, şuruplar, solüsyonlar, dekoksiyonlar ve merhemler gibi geleneksel farmasötik dozaj formları günümüzde hala kullanılmasına rağmen, fitokimyasalların absorpsiyonu, biyotransformasyonu ve stabilitesi ile ilgili problemler, bitkisel ilaçların etkinliğini, biyoyararlanımını ve bazı durumlarda güvenliğini azaltmaktadır. Ayrıca, geleneksel farmasötik dozaj formları genellikle bitkisel bileşiklerin hemen salınmasını sağlar. Gelişmiş ilaç taşıyıcı sistemlerin kullanılması, bahsedilen sorunların üstesinden gelmek için avantajlar sunmanın yanı sıra, minimum yan etkilerle ilişkili maksimum etkinlik ile uzun süreli salım sağlar. Yeni ilaç taşıyıcı sistemler kullanılarak bitkisel formülasyonların geliştirilmesi üzerine yapılan araştırmalar dikkat çekmiş ve nanoteknoloji tabanlı sistemlerin kullanımına ayrıca önem verilmiştir. Nano ilaç taşıyıcı sistemlerden biri de benzersiz özelliklere sahip olan ve bu sayede enfeksiyon, alerji, romatizmal hastalıklar, enflamatuvar hastalıklar, kanser gibi farklı hastalıkların tedavisinde yaygın olarak kullanılan nanoliflerdir. Bu çalışmada, çeşitli ilaç uygulama yollarıyla bitkisel biyoaktif maddelerin salınması amacıyla nanolif yapısındaki ilaç taşıyıcı sistemlerin kullanımı değerlendirilmiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	ESENTÜRK-GÜZEL I, ABDO L, ALGIN YAPAR E, Esentürk E, Büyükkayhan D, SINDHU R (2022). An Overview of Nanofiber Applications for Development of Phytopharmaceuticals. , 666 - 673. 10.14235/bas.galenos.2022.30502
Chicago	ESENTÜRK-GÜZEL IMREN,ABDO Lüceyn,ALGIN YAPAR Evren,Esentürk Engin,Büyükkayhan Derya,SINDHU Rakesh K An Overview of Nanofiber Applications for Development of Phytopharmaceuticals. (2022): 666 - 673. 10.14235/bas.galenos.2022.30502
MLA	ESENTÜRK-GÜZEL IMREN,ABDO Lüceyn,ALGIN YAPAR Evren,Esentürk Engin,Büyükkayhan Derya,SINDHU Rakesh K An Overview of Nanofiber Applications for Development of Phytopharmaceuticals. , 2022, ss.666 - 673. 10.14235/bas.galenos.2022.30502
AMA	ESENTÜRK-GÜZEL I,ABDO L,ALGIN YAPAR E,Esentürk E,Büyükkayhan D,SINDHU R An Overview of Nanofiber Applications for Development of Phytopharmaceuticals. . 2022; 666 - 673. 10.14235/bas.galenos.2022.30502
Vancouver	ESENTÜRK-GÜZEL I,ABDO L,ALGIN YAPAR E,Esentürk E,Büyükkayhan D,SINDHU R An Overview of Nanofiber Applications for Development of Phytopharmaceuticals. . 2022; 666 - 673. 10.14235/bas.galenos.2022.30502
IEEE	ESENTÜRK-GÜZEL I,ABDO L,ALGIN YAPAR E,Esentürk E,Büyükkayhan D,SINDHU R "An Overview of Nanofiber Applications for Development of Phytopharmaceuticals." , ss.666 - 673, 2022. 10.14235/bas.galenos.2022.30502
ISNAD	ESENTÜRK-GÜZEL, IMREN vd. "An Overview of Nanofiber Applications for Development of Phytopharmaceuticals". (2022), 666-673. https://doi.org/10.14235/bas.galenos.2022.30502

APA	ESENTÜRK-GÜZEL I, ABDO L, ALGIN YAPAR E, Esentürk E, Büyükkayhan D, SINDHU R (2022). An Overview of Nanofiber Applications for Development of Phytopharmaceuticals. Bezmiâlem Science, 10(5), 666 - 673. 10.14235/bas.galenos.2022.30502
Chicago	ESENTÜRK-GÜZEL IMREN,ABDO Lüceyn,ALGIN YAPAR Evren,Esentürk Engin,Büyükkayhan Derya,SINDHU Rakesh K An Overview of Nanofiber Applications for Development of Phytopharmaceuticals. Bezmiâlem Science 10, no.5 (2022): 666 - 673. 10.14235/bas.galenos.2022.30502
MLA	ESENTÜRK-GÜZEL IMREN,ABDO Lüceyn,ALGIN YAPAR Evren,Esentürk Engin,Büyükkayhan Derya,SINDHU Rakesh K An Overview of Nanofiber Applications for Development of Phytopharmaceuticals. Bezmiâlem Science, vol.10, no.5, 2022, ss.666 - 673. 10.14235/bas.galenos.2022.30502
AMA	ESENTÜRK-GÜZEL I,ABDO L,ALGIN YAPAR E,Esentürk E,Büyükkayhan D,SINDHU R An Overview of Nanofiber Applications for Development of Phytopharmaceuticals. Bezmiâlem Science. 2022; 10(5): 666 - 673. 10.14235/bas.galenos.2022.30502
Vancouver	ESENTÜRK-GÜZEL I,ABDO L,ALGIN YAPAR E,Esentürk E,Büyükkayhan D,SINDHU R An Overview of Nanofiber Applications for Development of Phytopharmaceuticals. Bezmiâlem Science. 2022; 10(5): 666 - 673. 10.14235/bas.galenos.2022.30502
IEEE	ESENTÜRK-GÜZEL I,ABDO L,ALGIN YAPAR E,Esentürk E,Büyükkayhan D,SINDHU R "An Overview of Nanofiber Applications for Development of Phytopharmaceuticals." Bezmiâlem Science, 10, ss.666 - 673, 2022. 10.14235/bas.galenos.2022.30502
ISNAD	ESENTÜRK-GÜZEL, IMREN vd. "An Overview of Nanofiber Applications for Development of Phytopharmaceuticals". Bezmiâlem Science 10/5 (2022), 666-673. https://doi.org/10.14235/bas.galenos.2022.30502