Characteristics of patients with hepatocellular carcinoma: A multicenter study

Background and Aim: The aim of the present study was to examine the etiology of hepatocellular carcinoma (HCC) by underlying cause and deter- mine the characteristics and clinical features of patients with HCC. Materials and Methods: The study comprised 1802 HCC patients diag- nosed and followed up by Liver Diseases Outpatient Clinics in 14 tertiary centers in Turkey between 2001 and 2020. Results: The mean age was 62.3±10.7 years, and 78% of them were males. Of the patients, 82% had cirrhosis. Hepatitis B virus (HBV) infection was the most common etiology (54%), followed by hepatitis C virus (HCV) infection (19%) and nonalcoholic fatty liver disease (NAFLD) (10%). Of the patients, 56% had a single lesion. Macrovascular invasion and extra- hepatic spread were present in 15% and 12% of the patients, respectively. The median serum alpha-fetoprotein level was 25.4 ng/mL. In total, 39% of the patients fulfilled the Milan Criteria. When we compared the character- istics of patients diagnosed before and after January 2016, the proportion of NAFLD-related HCC cases increased after 2016, from 6.6% to 13.4%. Conclusion: Chronic HBV and HCV infections remain the main causes of HCC in Turkey. The importance of NAFLD as a cause of HCC is increasing.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Güzelbulut F, karaoğullarından ü, Akkız H, ALTINTAS E, Demirtas C, BAHADIR Ö, Keklikkiran C, yıldırım a, gümüşsoy m, RIZAOĞLU BALCI H, GÖKÇEN P, Turan Gökçe D, Simsek C, TURAN I, Can G, Gokbulut V, Yaraş S, ADALI G, AKDOGAN R, AVCIOGLU U, Demir M, DOGANAY H, vatansever s, Gokcan H, Dilber F, Akdogan M, balaban h, simsek h, ozdogan o, Akarca U, karasu z, Günşar F, Idilman R (2022). Characteristics of patients with hepatocellular carcinoma: A multicenter study. , 71 - 76. 10.14744/hf.2022.2022.0028
Chicago	Güzelbulut Fatih,karaoğullarından ümit,Akkız Hikmet,ALTINTAS ENGIN,Demirtas Coskun,BAHADIR ÖZGÜR,Keklikkiran Caglayan,yıldırım abdullah emre,gümüşsoy mesut,RIZAOĞLU BALCI HATİCE,GÖKÇEN PINAR,Turan Gökçe Dilara,Simsek Cem,TURAN ILKER,Can Güray,Gokbulut Volkan,Yaraş Serkan,ADALI GUPSE,AKDOGAN REMZI ADNAN,AVCIOGLU UFUK,Demir Mehmet,DOGANAY HAMDI LEVENT,vatansever sezgin,Gokcan Hale,Dilber Feyza,Akdogan Meral,balaban hatice yasemin,simsek halis,ozdogan osman,Akarca Ulus Salih,karasu zeki,Günşar Fulya,Idilman Ramazan Characteristics of patients with hepatocellular carcinoma: A multicenter study. (2022): 71 - 76. 10.14744/hf.2022.2022.0028
MLA	Güzelbulut Fatih,karaoğullarından ümit,Akkız Hikmet,ALTINTAS ENGIN,Demirtas Coskun,BAHADIR ÖZGÜR,Keklikkiran Caglayan,yıldırım abdullah emre,gümüşsoy mesut,RIZAOĞLU BALCI HATİCE,GÖKÇEN PINAR,Turan Gökçe Dilara,Simsek Cem,TURAN ILKER,Can Güray,Gokbulut Volkan,Yaraş Serkan,ADALI GUPSE,AKDOGAN REMZI ADNAN,AVCIOGLU UFUK,Demir Mehmet,DOGANAY HAMDI LEVENT,vatansever sezgin,Gokcan Hale,Dilber Feyza,Akdogan Meral,balaban hatice yasemin,simsek halis,ozdogan osman,Akarca Ulus Salih,karasu zeki,Günşar Fulya,Idilman Ramazan Characteristics of patients with hepatocellular carcinoma: A multicenter study. , 2022, ss.71 - 76. 10.14744/hf.2022.2022.0028
AMA	Güzelbulut F,karaoğullarından ü,Akkız H,ALTINTAS E,Demirtas C,BAHADIR Ö,Keklikkiran C,yıldırım a,gümüşsoy m,RIZAOĞLU BALCI H,GÖKÇEN P,Turan Gökçe D,Simsek C,TURAN I,Can G,Gokbulut V,Yaraş S,ADALI G,AKDOGAN R,AVCIOGLU U,Demir M,DOGANAY H,vatansever s,Gokcan H,Dilber F,Akdogan M,balaban h,simsek h,ozdogan o,Akarca U,karasu z,Günşar F,Idilman R Characteristics of patients with hepatocellular carcinoma: A multicenter study. . 2022; 71 - 76. 10.14744/hf.2022.2022.0028
Vancouver	Güzelbulut F,karaoğullarından ü,Akkız H,ALTINTAS E,Demirtas C,BAHADIR Ö,Keklikkiran C,yıldırım a,gümüşsoy m,RIZAOĞLU BALCI H,GÖKÇEN P,Turan Gökçe D,Simsek C,TURAN I,Can G,Gokbulut V,Yaraş S,ADALI G,AKDOGAN R,AVCIOGLU U,Demir M,DOGANAY H,vatansever s,Gokcan H,Dilber F,Akdogan M,balaban h,simsek h,ozdogan o,Akarca U,karasu z,Günşar F,Idilman R Characteristics of patients with hepatocellular carcinoma: A multicenter study. . 2022; 71 - 76. 10.14744/hf.2022.2022.0028
IEEE	Güzelbulut F,karaoğullarından ü,Akkız H,ALTINTAS E,Demirtas C,BAHADIR Ö,Keklikkiran C,yıldırım a,gümüşsoy m,RIZAOĞLU BALCI H,GÖKÇEN P,Turan Gökçe D,Simsek C,TURAN I,Can G,Gokbulut V,Yaraş S,ADALI G,AKDOGAN R,AVCIOGLU U,Demir M,DOGANAY H,vatansever s,Gokcan H,Dilber F,Akdogan M,balaban h,simsek h,ozdogan o,Akarca U,karasu z,Günşar F,Idilman R "Characteristics of patients with hepatocellular carcinoma: A multicenter study." , ss.71 - 76, 2022. 10.14744/hf.2022.2022.0028
ISNAD	Güzelbulut, Fatih vd. "Characteristics of patients with hepatocellular carcinoma: A multicenter study". (2022), 71-76. https://doi.org/10.14744/hf.2022.2022.0028

APA	Güzelbulut F, karaoğullarından ü, Akkız H, ALTINTAS E, Demirtas C, BAHADIR Ö, Keklikkiran C, yıldırım a, gümüşsoy m, RIZAOĞLU BALCI H, GÖKÇEN P, Turan Gökçe D, Simsek C, TURAN I, Can G, Gokbulut V, Yaraş S, ADALI G, AKDOGAN R, AVCIOGLU U, Demir M, DOGANAY H, vatansever s, Gokcan H, Dilber F, Akdogan M, balaban h, simsek h, ozdogan o, Akarca U, karasu z, Günşar F, Idilman R (2022). Characteristics of patients with hepatocellular carcinoma: A multicenter study. Hepatology forum, 3(3), 71 - 76. 10.14744/hf.2022.2022.0028
Chicago	Güzelbulut Fatih,karaoğullarından ümit,Akkız Hikmet,ALTINTAS ENGIN,Demirtas Coskun,BAHADIR ÖZGÜR,Keklikkiran Caglayan,yıldırım abdullah emre,gümüşsoy mesut,RIZAOĞLU BALCI HATİCE,GÖKÇEN PINAR,Turan Gökçe Dilara,Simsek Cem,TURAN ILKER,Can Güray,Gokbulut Volkan,Yaraş Serkan,ADALI GUPSE,AKDOGAN REMZI ADNAN,AVCIOGLU UFUK,Demir Mehmet,DOGANAY HAMDI LEVENT,vatansever sezgin,Gokcan Hale,Dilber Feyza,Akdogan Meral,balaban hatice yasemin,simsek halis,ozdogan osman,Akarca Ulus Salih,karasu zeki,Günşar Fulya,Idilman Ramazan Characteristics of patients with hepatocellular carcinoma: A multicenter study. Hepatology forum 3, no.3 (2022): 71 - 76. 10.14744/hf.2022.2022.0028
MLA	Güzelbulut Fatih,karaoğullarından ümit,Akkız Hikmet,ALTINTAS ENGIN,Demirtas Coskun,BAHADIR ÖZGÜR,Keklikkiran Caglayan,yıldırım abdullah emre,gümüşsoy mesut,RIZAOĞLU BALCI HATİCE,GÖKÇEN PINAR,Turan Gökçe Dilara,Simsek Cem,TURAN ILKER,Can Güray,Gokbulut Volkan,Yaraş Serkan,ADALI GUPSE,AKDOGAN REMZI ADNAN,AVCIOGLU UFUK,Demir Mehmet,DOGANAY HAMDI LEVENT,vatansever sezgin,Gokcan Hale,Dilber Feyza,Akdogan Meral,balaban hatice yasemin,simsek halis,ozdogan osman,Akarca Ulus Salih,karasu zeki,Günşar Fulya,Idilman Ramazan Characteristics of patients with hepatocellular carcinoma: A multicenter study. Hepatology forum, vol.3, no.3, 2022, ss.71 - 76. 10.14744/hf.2022.2022.0028
AMA	Güzelbulut F,karaoğullarından ü,Akkız H,ALTINTAS E,Demirtas C,BAHADIR Ö,Keklikkiran C,yıldırım a,gümüşsoy m,RIZAOĞLU BALCI H,GÖKÇEN P,Turan Gökçe D,Simsek C,TURAN I,Can G,Gokbulut V,Yaraş S,ADALI G,AKDOGAN R,AVCIOGLU U,Demir M,DOGANAY H,vatansever s,Gokcan H,Dilber F,Akdogan M,balaban h,simsek h,ozdogan o,Akarca U,karasu z,Günşar F,Idilman R Characteristics of patients with hepatocellular carcinoma: A multicenter study. Hepatology forum. 2022; 3(3): 71 - 76. 10.14744/hf.2022.2022.0028
Vancouver	Güzelbulut F,karaoğullarından ü,Akkız H,ALTINTAS E,Demirtas C,BAHADIR Ö,Keklikkiran C,yıldırım a,gümüşsoy m,RIZAOĞLU BALCI H,GÖKÇEN P,Turan Gökçe D,Simsek C,TURAN I,Can G,Gokbulut V,Yaraş S,ADALI G,AKDOGAN R,AVCIOGLU U,Demir M,DOGANAY H,vatansever s,Gokcan H,Dilber F,Akdogan M,balaban h,simsek h,ozdogan o,Akarca U,karasu z,Günşar F,Idilman R Characteristics of patients with hepatocellular carcinoma: A multicenter study. Hepatology forum. 2022; 3(3): 71 - 76. 10.14744/hf.2022.2022.0028
IEEE	Güzelbulut F,karaoğullarından ü,Akkız H,ALTINTAS E,Demirtas C,BAHADIR Ö,Keklikkiran C,yıldırım a,gümüşsoy m,RIZAOĞLU BALCI H,GÖKÇEN P,Turan Gökçe D,Simsek C,TURAN I,Can G,Gokbulut V,Yaraş S,ADALI G,AKDOGAN R,AVCIOGLU U,Demir M,DOGANAY H,vatansever s,Gokcan H,Dilber F,Akdogan M,balaban h,simsek h,ozdogan o,Akarca U,karasu z,Günşar F,Idilman R "Characteristics of patients with hepatocellular carcinoma: A multicenter study." Hepatology forum, 3, ss.71 - 76, 2022. 10.14744/hf.2022.2022.0028
ISNAD	Güzelbulut, Fatih vd. "Characteristics of patients with hepatocellular carcinoma: A multicenter study". Hepatology forum 3/3 (2022), 71-76. https://doi.org/10.14744/hf.2022.2022.0028