TY  - JOUR
TI  - Characteristics of patients with hepatocellular carcinoma: A multicenter study
AB  - Background and Aim: The aim of the present study was to examine the etiology of hepatocellular carcinoma (HCC) by underlying cause and deter- mine the characteristics and clinical features of patients with HCC. Materials and Methods: The study comprised 1802 HCC patients diag- nosed and followed up by Liver Diseases Outpatient Clinics in 14 tertiary centers in Turkey between 2001 and 2020. Results: The mean age was 62.3±10.7 years, and 78% of them were males. Of the patients, 82% had cirrhosis. Hepatitis B virus (HBV) infection was the most common etiology (54%), followed by hepatitis C virus (HCV) infection (19%) and nonalcoholic fatty liver disease (NAFLD) (10%). Of the patients, 56% had a single lesion. Macrovascular invasion and extra- hepatic spread were present in 15% and 12% of the patients, respectively. The median serum alpha-fetoprotein level was 25.4 ng/mL. In total, 39% of the patients fulfilled the Milan Criteria. When we compared the character- istics of patients diagnosed before and after January 2016, the proportion of NAFLD-related HCC cases increased after 2016, from 6.6% to 13.4%. Conclusion: Chronic HBV and HCV infections remain the main causes of HCC in Turkey. The importance of NAFLD as a cause of HCC is increasing.
AU  - Can, Güray
AU  - Akkız, Hikmet
AU  - yıldırım, abdullah emre
AU  - ADALI, GUPSE
AU  - Gokcan, Hale
AU  - Keklikkiran, Caglayan
AU  - Turan Gökçe, Dilara
AU  - ozdogan, osman
AU  - Yaraş, Serkan
AU  - Idilman, Ramazan
AU  - BAHADIR, ÖZGÜR
AU  - Akdogan, Meral
AU  - DOGANAY, HAMDI LEVENT
AU  - ALTINTAS, ENGIN
AU  - Günşar, Fulya
AU  - Demirtas, Coskun
AU  - Simsek, Cem
AU  - GÖKÇEN, PINAR
AU  - gümüşsoy, mesut
AU  - balaban, hatice yasemin
AU  - RIZAOĞLU BALCI, HATİCE
AU  - karaoğullarından, ümit
AU  - Gokbulut, Volkan
AU  - Güzelbulut, Fatih
AU  - Dilber, Feyza
AU  - TURAN, ILKER
AU  - AKDOGAN, REMZI ADNAN
AU  - AVCIOGLU, UFUK
AU  - Demir, Mehmet
AU  - vatansever, sezgin
AU  - simsek, halis
AU  - Akarca, Ulus Salih
AU  - karasu, zeki
DO  - 10.14744/hf.2022.2022.0028
PY  - 2022
JO  - Hepatology forum
VL  - 3
IS  - 3
SN  - 1307-5888
SP  - 71
EP  - 76
DB  - TRDizin
UR  - http://search/yayin/detay/1173796
ER  -