Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats

Karaduman, Mert; acar, baver; Köker, Yasin; ARMANGİL, Mehmet; Yücel Tenekeci, Gözde; Akan, Burak

doi:10.5152/j.aott.2022.22106

Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats

Yasin KÖKER, (Ortopedi ve Travmatoloji Kliniği, Ankara 29 Mayıs Devlet Hastanesi, Ankara, Türkiye)

Mehmet ARMANGİL, (Ortopedi ve Travmatoloji Anabilim Dalı, El Cerrahisi Birimi, Ankara Üniversitesi Tıp Fakültesi, Ankara, Türkiye)

Mert KARADUMAN, (Ankara Keçiören Eğitim ve Araştırma Hastanesi Ortopedi ve Travmatoloji Kliniği, Ankara, Türkiye)

Gözde YÜCEL TENEKECİ, (Patoloji Anabilim Dalı, Ankara Üniversitesi, Veteriner Fakültesi, Ankara, Türkiye)

Baver ACAR, (Antalya Eğitim ve Araştırma Hastanesi Ortopedi ve Travmatoloji Kliniği, Antalya, Türkiye)

Burak AKAN (Ufuk Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı, Ankara, Türkiye)

Acta Orthopaedica et Traumatologica Turcica

3 0

Yıl: 2022 Cilt: 56 Sayı: 6 Sayfa Aralığı: 357 - 360 Metin Dili: İngilizce DOI: 10.5152/j.aott.2022.22106 İndeks Tarihi: 22-05-2023

Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats

Öz:

Objective: This study aimed to examine systemic erythropoietin’s effect on the Achilles tendon’s healing in a rat model. Methods: Twenty-five adult Wistar rats were randomly assigned to one of two groups. The Achilles tendon of each rat was transected 5 mm proximal to its insertion to the calcaneus. All Achilles tendons were then repaired using modified Kessler methods. A single dose (5000 U/kg) of intraperitoneal erythropoietin (EPO) was administered to group I. Group II was a control group and did not receive an EPO injection. Four rats from each group were sacrificed at 1, 3 and 6 weeks after injection. Histopathological assessments were performed by observers blinded to the treatment. Results: Groups I and II showed a similar increase in fibroblast cytoplasmic content and fibrillar collagen in the extracellular matrix. Collagen deposition, cellular proliferation, number of lipid vacuoles and capillary increases were similar between the groups. Conclusion: Evidence from this study has shown no direct effect of a single systemic high dose of EPO on the histological properties of the Achilles tendon in rats.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik

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APA	Köker Y, ARMANGİL M, Karaduman M, Yücel Tenekeci G, acar b, Akan B (2022). Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats. , 357 - 360. 10.5152/j.aott.2022.22106
Chicago	Köker Yasin,ARMANGİL Mehmet,Karaduman Mert,Yücel Tenekeci Gözde,acar baver,Akan Burak Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats. (2022): 357 - 360. 10.5152/j.aott.2022.22106
MLA	Köker Yasin,ARMANGİL Mehmet,Karaduman Mert,Yücel Tenekeci Gözde,acar baver,Akan Burak Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats. , 2022, ss.357 - 360. 10.5152/j.aott.2022.22106
AMA	Köker Y,ARMANGİL M,Karaduman M,Yücel Tenekeci G,acar b,Akan B Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats. . 2022; 357 - 360. 10.5152/j.aott.2022.22106
Vancouver	Köker Y,ARMANGİL M,Karaduman M,Yücel Tenekeci G,acar b,Akan B Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats. . 2022; 357 - 360. 10.5152/j.aott.2022.22106
IEEE	Köker Y,ARMANGİL M,Karaduman M,Yücel Tenekeci G,acar b,Akan B "Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats." , ss.357 - 360, 2022. 10.5152/j.aott.2022.22106
ISNAD	Köker, Yasin vd. "Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats". (2022), 357-360. https://doi.org/10.5152/j.aott.2022.22106

APA	Köker Y, ARMANGİL M, Karaduman M, Yücel Tenekeci G, acar b, Akan B (2022). Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats. Acta Orthopaedica et Traumatologica Turcica, 56(6), 357 - 360. 10.5152/j.aott.2022.22106
Chicago	Köker Yasin,ARMANGİL Mehmet,Karaduman Mert,Yücel Tenekeci Gözde,acar baver,Akan Burak Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats. Acta Orthopaedica et Traumatologica Turcica 56, no.6 (2022): 357 - 360. 10.5152/j.aott.2022.22106
MLA	Köker Yasin,ARMANGİL Mehmet,Karaduman Mert,Yücel Tenekeci Gözde,acar baver,Akan Burak Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats. Acta Orthopaedica et Traumatologica Turcica, vol.56, no.6, 2022, ss.357 - 360. 10.5152/j.aott.2022.22106
AMA	Köker Y,ARMANGİL M,Karaduman M,Yücel Tenekeci G,acar b,Akan B Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats. Acta Orthopaedica et Traumatologica Turcica. 2022; 56(6): 357 - 360. 10.5152/j.aott.2022.22106
Vancouver	Köker Y,ARMANGİL M,Karaduman M,Yücel Tenekeci G,acar b,Akan B Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats. Acta Orthopaedica et Traumatologica Turcica. 2022; 56(6): 357 - 360. 10.5152/j.aott.2022.22106
IEEE	Köker Y,ARMANGİL M,Karaduman M,Yücel Tenekeci G,acar b,Akan B "Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats." Acta Orthopaedica et Traumatologica Turcica, 56, ss.357 - 360, 2022. 10.5152/j.aott.2022.22106
ISNAD	Köker, Yasin vd. "Investigation into the effect of systemic single high-dose erythropoietin on the healing of Achilles tendons in rats". Acta Orthopaedica et Traumatologica Turcica 56/6 (2022), 357-360. https://doi.org/10.5152/j.aott.2022.22106