JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation
Yıl: 2022 Cilt: 55 Sayı: 3 Sayfa Aralığı: 278 - 282 Metin Dili: İngilizce DOI: 10.5505/aot.2022.87369 İndeks Tarihi: 22-05-2023
JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation
Öz: There is an increased risk of malignancy after solid organ transplantation. Acute myeloid leukemia is one of these malignancies. The translocation (8;21) is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The JAK2 V617F mutation is rarely seen in cases of de novo acute myeloid leukemia. There is no case with translocation (8;21) and JAK2 V617F mutation-positive acute myeloid leukemia after kidney transplantation in the literature. We report a 43 years old female patient who had a kidney transplant from her brother 10 years ago applied to our clinic with the complaint of fatigue. The JAK2 V617 mutation and translocation t(8;21) positive acute myeloid leukemia was detected in this patient. The patient received 3+7 remission induction treatments. After chemotherapy, translocation (8,21) and JAK2 V617F mutation were negative. Acute myeloid leukemia cases developing after kidney transplantation should be evaluated in terms of JAK2V617F mutation positivity.
Anahtar Kelime: Böbrek Nakli Sonrası JAK2 V617F Mutasyonu ve t(8;21) Pozitif Akut Miyeloid Lösemi
Öz: Solid organ transplantasyonundan sonra malignite riski artar. Akut miyeloid lösemi bu malignitelerden biridir. Translokasyon (8;21), akut miyeloid lösemide en sık görülen karyotipik anormalliklerden biridir. JAK2 V617F mutasyonu, de novo akut miyeloid lösemi vakalarında nadiren görülür. Literatürde böbrek nakli sonrası translokasyon (8;21) ve JAK2 V617F mutasyon pozitif akut miyeloid lösemi gelişen bir olgu yoktur. 10 yıl önce kardeşinden böbrek nakli olan 43 yaşında halsizlik şikayeti ile kliniğimize başvuran kadın hastayı sunduk. Bu hastada JAK2 V617 mutasyonu ve translokasyon t(8;21) pozitif akut miyeloid lösemi tespit edildi. Hasta 3+7 remisyon indüksiyon tedavisi aldı. Kemoterapi sonrası translokasyon (8,21) ve JAK2 V617F mutasyonu negatifti. Böbrek nakli sonrası gelişen akut miyeloid lösemi olguları JAK2V617F mutasyon pozitifliği açısından değerlendirilmelidir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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| APA | SİNCAN g, ALTUNOK M, Yuce Kahraman C, erdem f (2022). JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation. , 278 - 282. 10.5505/aot.2022.87369 |
| Chicago | SİNCAN gulden,ALTUNOK Murat,Yuce Kahraman Cigdem,erdem fuat JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation. (2022): 278 - 282. 10.5505/aot.2022.87369 |
| MLA | SİNCAN gulden,ALTUNOK Murat,Yuce Kahraman Cigdem,erdem fuat JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation. , 2022, ss.278 - 282. 10.5505/aot.2022.87369 |
| AMA | SİNCAN g,ALTUNOK M,Yuce Kahraman C,erdem f JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation. . 2022; 278 - 282. 10.5505/aot.2022.87369 |
| Vancouver | SİNCAN g,ALTUNOK M,Yuce Kahraman C,erdem f JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation. . 2022; 278 - 282. 10.5505/aot.2022.87369 |
| IEEE | SİNCAN g,ALTUNOK M,Yuce Kahraman C,erdem f "JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation." , ss.278 - 282, 2022. 10.5505/aot.2022.87369 |
| ISNAD | SİNCAN, gulden vd. "JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation". (2022), 278-282. https://doi.org/10.5505/aot.2022.87369 |
| APA | SİNCAN g, ALTUNOK M, Yuce Kahraman C, erdem f (2022). JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation. ACTA ONCOLOGICA TURCICA, 55(3), 278 - 282. 10.5505/aot.2022.87369 |
| Chicago | SİNCAN gulden,ALTUNOK Murat,Yuce Kahraman Cigdem,erdem fuat JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation. ACTA ONCOLOGICA TURCICA 55, no.3 (2022): 278 - 282. 10.5505/aot.2022.87369 |
| MLA | SİNCAN gulden,ALTUNOK Murat,Yuce Kahraman Cigdem,erdem fuat JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation. ACTA ONCOLOGICA TURCICA, vol.55, no.3, 2022, ss.278 - 282. 10.5505/aot.2022.87369 |
| AMA | SİNCAN g,ALTUNOK M,Yuce Kahraman C,erdem f JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation. ACTA ONCOLOGICA TURCICA. 2022; 55(3): 278 - 282. 10.5505/aot.2022.87369 |
| Vancouver | SİNCAN g,ALTUNOK M,Yuce Kahraman C,erdem f JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation. ACTA ONCOLOGICA TURCICA. 2022; 55(3): 278 - 282. 10.5505/aot.2022.87369 |
| IEEE | SİNCAN g,ALTUNOK M,Yuce Kahraman C,erdem f "JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation." ACTA ONCOLOGICA TURCICA, 55, ss.278 - 282, 2022. 10.5505/aot.2022.87369 |
| ISNAD | SİNCAN, gulden vd. "JAK2 V617F Mutation and t(8;21) Positive Acute Myeloid Leukemia After Renal Transplantation". ACTA ONCOLOGICA TURCICA 55/3 (2022), 278-282. https://doi.org/10.5505/aot.2022.87369 |
