The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study

Öz:

Objective: Genistein has an anti-inflammatory effect that may be beneficial in many inflammatory diseases. The aim of this study was to determine the effects of supplementation of oral/enteral nutrition (EN) with genistein on the level of inflammatory cytokines in septic patients. Materials and Methods: This prospective, randomized controlled study included critically ill adult patients with sepsis receiving EN or oral/EN. The patients were randomly divided into a genistein or a control group. Genistein (60 mg/day) was administered as a supplement to EN in the genistein group and the control group received only EN or oral/EN. Serum interleukin 1 beta (IL- 1β), interleukin 6 (IL-6), high mobility group box 1 protein (HMGB-1), tumor necrosis factor alfa (TNF-α), procalcitonin (PCT), and C-reactive protein (CRP) concentrations were serially measured at the baseline, 24th hour, and 72nd hour after admission. Results: Thirty-two participants (genistein group: 16 patients, control group: 16 patients) were included. The mean age was 56±17 years. The serum IL-1β concentration in the genistein group was significantly higher than that of the control group in follow-up (p=0.001). The control group had a significantly lower serum IL-6 value at the 72nd hour compared with the baseline and 24th-hour values (p=0.001). The TNF-α concentration was significantly greater (p<0.001, both groups), while the PCT values were lower in follow-up measurements (genistein group: p=0.031; control group: p=0.004). The CRP level was higher in the genistein group than in the control group at the baseline (p=0.019) and significantly lower in follow-up measurements (p=0.028). At all of the study time points, the serum IL-6, TNF-α, HMGB-1, and PCT level of the genistein group was similar to that of the control group. Conclusion: Genistein supplementation may add to the inflammation process and worsen the prognosis of sepsis patients in the acute period.

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APA	Elay G, Gündoğan K, Güntürk İ, Temel Ş, OZER N, Sipahioğlu H, Kucuk O, YAZICI C, Güven M, Sungur M (2023). The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study. , 131 - 137. 10.14744/etd.2022.55492
Chicago	Elay Gülseren,Gündoğan Kürşat,Güntürk İnayet,Temel Şahin,OZER NURHAYAT TUGRA,Sipahioğlu Hilal,Kucuk Omer,YAZICI Cevat,Güven Muhammet,Sungur Murat The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study. (2023): 131 - 137. 10.14744/etd.2022.55492
MLA	Elay Gülseren,Gündoğan Kürşat,Güntürk İnayet,Temel Şahin,OZER NURHAYAT TUGRA,Sipahioğlu Hilal,Kucuk Omer,YAZICI Cevat,Güven Muhammet,Sungur Murat The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study. , 2023, ss.131 - 137. 10.14744/etd.2022.55492
AMA	Elay G,Gündoğan K,Güntürk İ,Temel Ş,OZER N,Sipahioğlu H,Kucuk O,YAZICI C,Güven M,Sungur M The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study. . 2023; 131 - 137. 10.14744/etd.2022.55492
Vancouver	Elay G,Gündoğan K,Güntürk İ,Temel Ş,OZER N,Sipahioğlu H,Kucuk O,YAZICI C,Güven M,Sungur M The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study. . 2023; 131 - 137. 10.14744/etd.2022.55492
IEEE	Elay G,Gündoğan K,Güntürk İ,Temel Ş,OZER N,Sipahioğlu H,Kucuk O,YAZICI C,Güven M,Sungur M "The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study." , ss.131 - 137, 2023. 10.14744/etd.2022.55492
ISNAD	Elay, Gülseren vd. "The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study". (2023), 131-137. https://doi.org/10.14744/etd.2022.55492

APA	Elay G, Gündoğan K, Güntürk İ, Temel Ş, OZER N, Sipahioğlu H, Kucuk O, YAZICI C, Güven M, Sungur M (2023). The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study. Erciyes Medical Journal, 45(2), 131 - 137. 10.14744/etd.2022.55492
Chicago	Elay Gülseren,Gündoğan Kürşat,Güntürk İnayet,Temel Şahin,OZER NURHAYAT TUGRA,Sipahioğlu Hilal,Kucuk Omer,YAZICI Cevat,Güven Muhammet,Sungur Murat The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study. Erciyes Medical Journal 45, no.2 (2023): 131 - 137. 10.14744/etd.2022.55492
MLA	Elay Gülseren,Gündoğan Kürşat,Güntürk İnayet,Temel Şahin,OZER NURHAYAT TUGRA,Sipahioğlu Hilal,Kucuk Omer,YAZICI Cevat,Güven Muhammet,Sungur Murat The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study. Erciyes Medical Journal, vol.45, no.2, 2023, ss.131 - 137. 10.14744/etd.2022.55492
AMA	Elay G,Gündoğan K,Güntürk İ,Temel Ş,OZER N,Sipahioğlu H,Kucuk O,YAZICI C,Güven M,Sungur M The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study. Erciyes Medical Journal. 2023; 45(2): 131 - 137. 10.14744/etd.2022.55492
Vancouver	Elay G,Gündoğan K,Güntürk İ,Temel Ş,OZER N,Sipahioğlu H,Kucuk O,YAZICI C,Güven M,Sungur M The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study. Erciyes Medical Journal. 2023; 45(2): 131 - 137. 10.14744/etd.2022.55492
IEEE	Elay G,Gündoğan K,Güntürk İ,Temel Ş,OZER N,Sipahioğlu H,Kucuk O,YAZICI C,Güven M,Sungur M "The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study." Erciyes Medical Journal, 45, ss.131 - 137, 2023. 10.14744/etd.2022.55492
ISNAD	Elay, Gülseren vd. "The Effects of Genistein as Supplement to Oral/ Enteral Nutrition on Inflammatory Cytokines in Septic ICU patients: A Prospective, Single-center, Randomized Controlled Pilot Study". Erciyes Medical Journal 45/2 (2023), 131-137. https://doi.org/10.14744/etd.2022.55492