Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer

Şimşek, Yağmur; Erbiyik, Halil Ibrahim; Palalıoğlu, Rabia Merve

doi:10.4274/hamidiyemedj.galenos.2023.96158

Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer

Rabia Merve PALALIOĞLU, (University of Health Sciences Türkiye, Ümraniye Training and Research Hospital, Department of Obstetrics and Gynecology, İstanbul, Türkiye)

Halil İbrahim ERBIYIK, (Üsküdar University, Operation Room Services & Dr. Moral Obstetrics and Gynecology Clinic, İstanbul, Türkiye)

Ya mur FİİMFLEK (University of Health Sciences Türkiye, Ümraniye Training and Research Hospital, Department of Obstetrics and Gynecology, İstanbul, Türkiye)

Hamidiye Medical Journal

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Yıl: 2023 Cilt: 4 Sayı: 1 Sayfa Aralığı: 40 - 49 Metin Dili: İngilizce DOI: 10.4274/hamidiyemedj.galenos.2023.96158 İndeks Tarihi: 23-05-2023

Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer

Öz:

Background: Endometrial cancer (EC) is one of the most commonly diagnosed cancers, particularly in patients aged 60-70 years. Several studies have explored the potential of ABO blood groups as markers for early detection of different types of cancers; however, no conclusive study has been conducted for evaluating the effectiveness of ABO blood groups in early detection of EC. To determine the prevalence of the ABO blood groups in patients with EC, examine whether certain blood groups are highly associated with early-stage EC, and investigate the relationship between the ABO blood groups and clinical and pathological prognostic parameters in patients with EC. Materials and Methods: The prevalence of ABO blood groups in patients who were operated between 2010 and 2020 and diagnosed with atypical endometrial hyperplasia and non-metastatic, International Federation of Gynecology and Obstetrics early stage (I and II) EC was investigated. Results: The blood group distribution of 575 patients in the study population was found to be A>O>B>AB, in order of frequency. The blood groups B, A, and AB were the most frequently found in women with atypical endometrial hyperplasia, endometrioid adenocarcinoma or uterine sarcoma, and non-endometrioid adenocarcinoma, respectively (p>0.05). The blood groups A, O, and B were the most common in grades 1, 2, and 3 EC tumors, respectively. Although the age of patients at menopause and diagnosis was found to be lower in those with the blood group AB than in the patients with other blood groups, no significant difference was found among the blood groups in terms of the mean age at diagnosis and menopause (p>0.05). Conclusion: The results indicate that blood groups have no diagnostic value in the early detection of EC, and hence, cannot be used to predict the risk of EC subtypes, tumor grade, or menopause age

Anahtar Kelime:

Erken Evre Endometrial Kanserde Menopoz ve Tanı Yaşı, Tümör Derecesi ve Alt Tipi ve ABO Kan Gruplarının Prevalansı Arasındaki İlişki

Öz:

Amaç: Endometrial kanser (EK), özellikle 60-70 yaş arası hastalarda en sık teşhis edilen kanserlerden biridir. Çeşitli araştırmalar, ABO kan gruplarının farklı kanser türlerinin erken teşhisi için belirteç olarak potansiyelini araştırmıştır; ancak EK’nin erken saptanmasında ABO kan gruplarının etkinliğini değerlendirmek için kesin bir çalışma yapılmamıştır. EK’li hastalarda ABO kan gruplarının prevalansını belirlemek, belirli kan gruplarının erken evre EK ile yüksek oranda ilişkili olup olmadığını incelemek ve EK’li hastalarda ABO kan grupları ile klinik ve patolojik prognostik parametreler arasındaki ilişkiyi araştırmak amaçlanmıştır. Gereç ve Yöntemler: 2010-2020 yılları arasında opere edilen, atipik endometriyal hiperplazi ve non-metastatic, Uluslararası Jinekoloji ve Obstetrik Federasyonu erken evre (I ve II) EK tanısı alan hastalarda ABO kan gruplarının prevalansı incelendi. Bulgular: Çalışma popülasyonundaki 575 hastanın kan grubu dağılımı sıklık sırasına göre A>O>B>AB olarak bulundu. Atipili endometrial hiperplazisi olan kadınların çoğunda B kan grubu, endometrioid adenokanser veya uterin sarkom tespit edilen kadınların çoğunda A kan grubu, non-endometrioid adenokanseri olan kadınların çoğunda AB kan grubu tespit edilmiştir (p>0,05). Grade 1 olanlarda yine, en sık A kan grubu, grade 2’de O ve grade 3 olanlarda en sık B kan grubu izlenmiştir. Kan grubu AB olanların menopoz ve tanı anındaki yaşı daha düşük bulunmuşken (p>0,05), kan grupları arasında tanı anındaki yaş ve menopoz yaşı ortalamaları anlamlı bulunmamıştır. Sonuç: Bulgular, kan gruplarının EK erken dönem tespitine yardımcı olamayacağını göstermektedir. Belirli bir kan grubunun EK alt tipleri riskini artırdığı, tümör derecesini veya menopoz yaşını etkilediği söylenemez.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Palalıoğlu R, Erbiyik H, Şimşek Y (2023). Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer. , 40 - 49. 10.4274/hamidiyemedj.galenos.2023.96158
Chicago	Palalıoğlu Rabia Merve,Erbiyik Halil Ibrahim,Şimşek Yağmur Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer. (2023): 40 - 49. 10.4274/hamidiyemedj.galenos.2023.96158
MLA	Palalıoğlu Rabia Merve,Erbiyik Halil Ibrahim,Şimşek Yağmur Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer. , 2023, ss.40 - 49. 10.4274/hamidiyemedj.galenos.2023.96158
AMA	Palalıoğlu R,Erbiyik H,Şimşek Y Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer. . 2023; 40 - 49. 10.4274/hamidiyemedj.galenos.2023.96158
Vancouver	Palalıoğlu R,Erbiyik H,Şimşek Y Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer. . 2023; 40 - 49. 10.4274/hamidiyemedj.galenos.2023.96158
IEEE	Palalıoğlu R,Erbiyik H,Şimşek Y "Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer." , ss.40 - 49, 2023. 10.4274/hamidiyemedj.galenos.2023.96158
ISNAD	Palalıoğlu, Rabia Merve vd. "Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer". (2023), 40-49. https://doi.org/10.4274/hamidiyemedj.galenos.2023.96158

APA	Palalıoğlu R, Erbiyik H, Şimşek Y (2023). Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer. Hamidiye Medical Journal , 4(1), 40 - 49. 10.4274/hamidiyemedj.galenos.2023.96158
Chicago	Palalıoğlu Rabia Merve,Erbiyik Halil Ibrahim,Şimşek Yağmur Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer. Hamidiye Medical Journal 4, no.1 (2023): 40 - 49. 10.4274/hamidiyemedj.galenos.2023.96158
MLA	Palalıoğlu Rabia Merve,Erbiyik Halil Ibrahim,Şimşek Yağmur Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer. Hamidiye Medical Journal , vol.4, no.1, 2023, ss.40 - 49. 10.4274/hamidiyemedj.galenos.2023.96158
AMA	Palalıoğlu R,Erbiyik H,Şimşek Y Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer. Hamidiye Medical Journal . 2023; 4(1): 40 - 49. 10.4274/hamidiyemedj.galenos.2023.96158
Vancouver	Palalıoğlu R,Erbiyik H,Şimşek Y Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer. Hamidiye Medical Journal . 2023; 4(1): 40 - 49. 10.4274/hamidiyemedj.galenos.2023.96158
IEEE	Palalıoğlu R,Erbiyik H,Şimşek Y "Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer." Hamidiye Medical Journal , 4, ss.40 - 49, 2023. 10.4274/hamidiyemedj.galenos.2023.96158
ISNAD	Palalıoğlu, Rabia Merve vd. "Relationship Among Menopause and Diagnosis Age, Tumor Grade and Subtype, and Prevalence of ABO Blood Groups in Early-stage Endometrial Cancer". Hamidiye Medical Journal 4/1 (2023), 40-49. https://doi.org/10.4274/hamidiyemedj.galenos.2023.96158