Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk

esenbuğa, şeyma; ATEŞ, COŞKUN; Cander, Soner; Ersoy, Canan; Erturk, Erdinc; Aydemir, Ensar; aydoğan ünsal, yasemin; Oz Gul, Ozen

doi:10.14744/etd.2023.83809

Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk

Yasemin AYDOĞAN ÜNSAL, (Yenimahalle Eğitim ve Araştırma Hastanesi, Endokrinoloji Bölümü ve Metabolizma Hastalıkları, Yıldırım Beyazıt Üniversitesi, Ankara, Türkiye)

Özen ÖZ GÜL, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Endokrinoloji Bölümü ve Metabolizma Hastalıkları, Bursa, Türkiye)

Şeyma ESENBUĞA, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Dahili Tıp Bölüm, Bursa, Türkiye)

Coşkun ATEŞ, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Endokrinoloji Bölümü ve Metabolizma Hastalıkları, Bursa, Türkiye)

Ensar AYDEMİR, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Endokrinoloji Bölümü ve Metabolizma Hastalıkları, Bursa, Türkiye)

Soner CANDER, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Endokrinoloji Bölümü ve Metabolizma Hastalıkları, Bursa, Türkiye)

Canan ERSOY, (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Endokrinoloji Bölümü ve Metabolizma Hastalıkları, Bursa, Türkiye)

Erdinç ERTÜRK (Bursa Uludağ Üniversitesi, Tıp Fakültesi, Endokrinoloji Bölümü ve Metabolizma Hastalıkları, Bursa, Türkiye)

Erciyes Medical Journal

2 0

Yıl: 2023 Cilt: 45 Sayı: 2 Sayfa Aralığı: 190 - 196 Metin Dili: İngilizce DOI: 10.14744/etd.2023.83809 İndeks Tarihi: 23-05-2023

Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk

Öz:

Objective: This report aimed to examine changes in constituents of body composition that correlate to cardiovascular morbidity and mortality in patients with acromegaly using bioelectrical impedance analysis (BIA). Materials and Methods: This prospective study included 62 patients who were followed up after their acromegaly diagnosis and 40 healthy volunteers. All patients’ body compositions were evaluated using a body composition analyzer (TANITA MC-780-Black) with the BIA method. The laboratory and anthropometric measurements and body composition parameters were compared between the patients with acromegaly and the controls. Moreover, these parameters were examined according to the disease activity. Results: This study showed that patients with acromegaly have higher plasma glucose levels than the control group (p=0.001). The homeostasis model assessment-insulin resistance index of patients with acromegaly was significantly higher than that of the controls (p=0.02). The compartments of intracellular water (ICW) and extracellular water (ECW) in the patients with acromegaly were larger than that in the controls (respectively; p=0.02 and p=0.001). The lean mass of the patients with acromegaly in the trunk and extremities was significantly higher than the controls (respectively; p=0.002 and p=0.001). The compartment of muscle was significantly larger than that in the controls (p=0.001). The basal metabolism in patients with acromegaly was significantly higher than that in the controls (p=0.002). Conclusion: Determining the body composition using the BIA method can provide important information about the cardiovascular risks in patients with acromegaly. With the BIA method, cardiovascular risk can be estimated and reduced with effective strategies.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Vilar L, Vilar CF, Lyra R, Lyra R, Naves LA. Acromegaly: clinical features at diagnosis. Pituitary 2017; 20(1): 22–32.
2. Rolla M, Jawiarczyk-Przybyłowska A, Halupczok-Żyła J, Kałużny M, Konopka BM, Błoniecka I, et al. Complications and Comorbidities of Acromegaly-Retrospective Study in Polish Center. Front Endocrinol (Lausanne). 2021 Mar 16;12: 642131. doi: 10.3389/fendo. 2021.642131.
3. Freda PU, Shen W, Heymsfield SB, Reyes-Vidal CM, Geer EB, Bruce JN, et al. Lower visceral and subcutaneous but higher intermuscular adipose tissue depots in patients with growth hormone and insulin-like growth factor I excess due to acromegaly. J Clin Endocrinol Metab 2008; 93(6): 2334–43.
4. Dreval AV, Trigolosova IV, Misnikova IV, Kovalyova YA, Tishenina RS, Barsukov IA, et al. Prevalence of diabetes mellitus in patients with acromegaly. Endocr Connect 2014; 3(2): 93–8.
5. Gadelha MR, Kasuki L, Lim DST, Fleseriu M. Systemic complications of acromegaly and the impact of the current treatment landscape: An Update. Endocr Rev 2019; 40(1): 268–332.
6. Reyes-Vidal CM, Mojahed H, Shen W, Jin Z, Arias-Mendoza F, Fernandez JC, et al. Adipose tissue redistribution and ectopic lipid deposition in active acromegaly and effects of surgical treatment. J Clin Endocrinol Metab 2015; 100(8): 2946–55.
7. Guo X, Gao L, Shi X, Li H, Wang Q, Wang Z, et al. Pre- and postoperative body composition and metabolic characteristics in patients with acromegaly: A prospective study. Int J Endocrinol 2018; 2018: 4125013.
8. Bredella MA, Schorr M, Dichtel LE, Gerweck AV, Young BJ, Woodmansee WW, et al. Body composition and ectopic lipid changes with biochemical control of acromegaly. J Clin Endocrinol Metab 2017; 102(11): 4218–25.
9. Katznelson L. Alterations in body composition in acromegaly. Pituitary 2009; 12(2): 136–42.
10. Lin YC, Yu WC, Kuo CS, Chen HS. Growth hormone control and cardiovascular function in patients with acromegaly. J Chin Med Assoc 2021; 84(2): 165–70.
11. Mizera Ł, Elbaum M, Daroszewski J, Bolanowski M. Cardiovascular complicatıons of acromegaly. Acta Endocrinol (Buchar) 2018; 14(3): 365–74.
12. Puglisi S, Terzolo M. Hypertension and acromegaly. Endocrinol Metab Clin North Am 2019; 48(4): 779–93.
13. Møller N, Schmitz O, Jøorgensen JO, Astrup J, Bak JF, Christensen SE, et al. Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy. J Clin Endocrinol Metab 1992; 74(5): 1012–9.
14. Reid TJ, Jin Z, Shen W, Reyes-Vidal CM, Fernandez JC, Bruce JN, et al. IGF-1 levels across the spectrum of normal to elevated in acromegaly: relationship to insulin sensitivity, markers of cardiovascular risk and body composition. Pituitary 2015; 18(6): 808–19.
15. Brummer RJ, Lönn L, Kvist H, Grangård U, Bengtsson BA, Sjöström L. Adipose tissue and muscle volume determination by computed tomography in acromegaly, before and 1 year after adenomectomy. Eur J Clin Invest 1993; 23(4): 199–205.
16. Bosy-Westphal A, Schautz B, Later W, Kehayias JJ, Gallagher D, Müller MJ. What makes a BIA equation unique? Validity of eight-electrode multifrequency BIA to estimate body composition in a healthy adult population. Eur J Clin Nutr 2013; 67 Suppl 1: S14–21.
17. Sun SS, Chumlea WC, Heymsfield SB, Lukaski HC, Schoeller D, Friedl K, et al. Development of bioelectrical impedance analysis prediction equations for body composition with the use of a multicomponent model for use in epidemiologic surveys. Am J Clin Nutr 2003; 77(2): 331–40.
18. Wolters TLC, Netea MG, Riksen NP, Hermus ARMM, Netea-Maier RT. Acromegaly, inflammation and cardiovascular disease: a review. Rev Endocr Metab Disord 2020; 21(4): 547–68.
19. Kamenický P, Maione L, Chanson P. Cardiovascular complications of acromegaly. Ann Endocrinol (Paris) 2021; 82(3-4): 206–9.
20. Katznelson L, Laws ER Jr, Melmed S, Molitch ME, Murad MH, Utz A, et al; Endocrine Society. Acromegaly: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2014; 99(11): 3933–51.
21. Olarescu NC, Bollerslev J. The impact of adipose tissue on insulin resistance in acromegaly. Trends Endocrinol Metab 2016; 27(4): 226–37.
22. Mazziotti G, Lania AG, Canalis E. Skeletal disorders associated with the growth hormone-insulin-like growth factor 1 axis. Nat Rev Endocrinol 2022; 18(6): 353–65.
23. Mazziotti G, Biagioli E, Maffezzoni F, Spinello M, Serra V, Maroldi R, et al. Bone turnover, bone mineral density, and fracture risk in acromegaly: a meta-analysis. J Clin Endocrinol Metab 2015; 100(2): 384–94.
24. Kaji H, Sugimoto T, Nakaoka D, Okimura Y, Kaji H, Abe H, et al. Bone metabolism and body composition in Japanese patients with active acromegaly. Clin Endocrinol (Oxf) 2001; 55(2): 175–81.
25. Leães CGS, Fernandes MV, Alves L, Araújo B, Rech CGSL, Ferreira NP, et al. Assessment of anthropometric and physical health ındicators before and after pituitary surgery in patients with nonfunctioning pituitary adenomas, acromegaly, and cushing disease. Indian J Endocrinol Metab 2019; 23(4): 473–9.
26. Deurenberg P, Andreoli A, Borg P, Kukkonen-Harjula K, de Lorenzo A, van Marken et al. The validity of predicted body fat percentage from body mass index and from impedance in samples of five European populations. Eur J Clin Nutr 2001; 55(11): 973–9.

APA	aydoğan ünsal y, Oz Gul O, esenbuğa ş, ATEŞ C, Aydemir E, Cander S, Ersoy C, Erturk E (2023). Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk. , 190 - 196. 10.14744/etd.2023.83809
Chicago	aydoğan ünsal yasemin,Oz Gul Ozen,esenbuğa şeyma,ATEŞ COŞKUN,Aydemir Ensar,Cander Soner,Ersoy Canan,Erturk Erdinc Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk. (2023): 190 - 196. 10.14744/etd.2023.83809
MLA	aydoğan ünsal yasemin,Oz Gul Ozen,esenbuğa şeyma,ATEŞ COŞKUN,Aydemir Ensar,Cander Soner,Ersoy Canan,Erturk Erdinc Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk. , 2023, ss.190 - 196. 10.14744/etd.2023.83809
AMA	aydoğan ünsal y,Oz Gul O,esenbuğa ş,ATEŞ C,Aydemir E,Cander S,Ersoy C,Erturk E Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk. . 2023; 190 - 196. 10.14744/etd.2023.83809
Vancouver	aydoğan ünsal y,Oz Gul O,esenbuğa ş,ATEŞ C,Aydemir E,Cander S,Ersoy C,Erturk E Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk. . 2023; 190 - 196. 10.14744/etd.2023.83809
IEEE	aydoğan ünsal y,Oz Gul O,esenbuğa ş,ATEŞ C,Aydemir E,Cander S,Ersoy C,Erturk E "Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk." , ss.190 - 196, 2023. 10.14744/etd.2023.83809
ISNAD	aydoğan ünsal, yasemin vd. "Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk". (2023), 190-196. https://doi.org/10.14744/etd.2023.83809

APA	aydoğan ünsal y, Oz Gul O, esenbuğa ş, ATEŞ C, Aydemir E, Cander S, Ersoy C, Erturk E (2023). Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk. Erciyes Medical Journal, 45(2), 190 - 196. 10.14744/etd.2023.83809
Chicago	aydoğan ünsal yasemin,Oz Gul Ozen,esenbuğa şeyma,ATEŞ COŞKUN,Aydemir Ensar,Cander Soner,Ersoy Canan,Erturk Erdinc Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk. Erciyes Medical Journal 45, no.2 (2023): 190 - 196. 10.14744/etd.2023.83809
MLA	aydoğan ünsal yasemin,Oz Gul Ozen,esenbuğa şeyma,ATEŞ COŞKUN,Aydemir Ensar,Cander Soner,Ersoy Canan,Erturk Erdinc Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk. Erciyes Medical Journal, vol.45, no.2, 2023, ss.190 - 196. 10.14744/etd.2023.83809
AMA	aydoğan ünsal y,Oz Gul O,esenbuğa ş,ATEŞ C,Aydemir E,Cander S,Ersoy C,Erturk E Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk. Erciyes Medical Journal. 2023; 45(2): 190 - 196. 10.14744/etd.2023.83809
Vancouver	aydoğan ünsal y,Oz Gul O,esenbuğa ş,ATEŞ C,Aydemir E,Cander S,Ersoy C,Erturk E Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk. Erciyes Medical Journal. 2023; 45(2): 190 - 196. 10.14744/etd.2023.83809
IEEE	aydoğan ünsal y,Oz Gul O,esenbuğa ş,ATEŞ C,Aydemir E,Cander S,Ersoy C,Erturk E "Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk." Erciyes Medical Journal, 45, ss.190 - 196, 2023. 10.14744/etd.2023.83809
ISNAD	aydoğan ünsal, yasemin vd. "Determining the Body Composition of Patients with Acromegaly as a Cardiovascular Risk". Erciyes Medical Journal 45/2 (2023), 190-196. https://doi.org/10.14744/etd.2023.83809