A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation
Yıl: 2023 Cilt: 45 Sayı: 2 Sayfa Aralığı: 207 - 210 Metin Dili: İngilizce DOI: 10.14744/etd.2022.33866 İndeks Tarihi: 23-05-2023
A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation
Öz: Background: Hemophagocytic lymphohistiocytosis (HLH) is classified as primary or secondary. While primary (familial) HLH is caused by genetic mutations, secondary (acquired, reactive) HLH is the type that has an underlying cause and is not associated with genetic mutations. Case Report: We report a two-year-old female patient with a fatal course of Fusarium sepsis who was diagnosed with primary HLH. A homozygous variant of PRF1 (c.445G > A, p.Gly149Ser) was detected. Hyphal growth was detected on Sabouraud dextrose agar and Fusarium multiplied in blood cultures. The patient’s clinical course was fulminant, and she died of septic shock 4 days after admission to the hospital. Fusarium, a rare infection in HLH, was found in this case. Conclusion: We discovered the rare PRF1 (c.445G>A, p.Gly149Ser) mutation in HLH and the high morbidity and mortality associated with Fusarium infection.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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| APA | Dündar M, ORAK F, Acıpayam C, Aslan K, gök v, Cetin B, UNAL E, Klein C, Akyıldız B (2023). A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation. , 207 - 210. 10.14744/etd.2022.33866 |
| Chicago | Dündar Mehmet Akif,ORAK FİLİZ,Acıpayam Can,Aslan Kübra,gök veysel,Cetin Benhur,UNAL Ekrem,Klein Christoph,Akyıldız Basak Nur A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation. (2023): 207 - 210. 10.14744/etd.2022.33866 |
| MLA | Dündar Mehmet Akif,ORAK FİLİZ,Acıpayam Can,Aslan Kübra,gök veysel,Cetin Benhur,UNAL Ekrem,Klein Christoph,Akyıldız Basak Nur A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation. , 2023, ss.207 - 210. 10.14744/etd.2022.33866 |
| AMA | Dündar M,ORAK F,Acıpayam C,Aslan K,gök v,Cetin B,UNAL E,Klein C,Akyıldız B A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation. . 2023; 207 - 210. 10.14744/etd.2022.33866 |
| Vancouver | Dündar M,ORAK F,Acıpayam C,Aslan K,gök v,Cetin B,UNAL E,Klein C,Akyıldız B A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation. . 2023; 207 - 210. 10.14744/etd.2022.33866 |
| IEEE | Dündar M,ORAK F,Acıpayam C,Aslan K,gök v,Cetin B,UNAL E,Klein C,Akyıldız B "A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation." , ss.207 - 210, 2023. 10.14744/etd.2022.33866 |
| ISNAD | Dündar, Mehmet Akif vd. "A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation". (2023), 207-210. https://doi.org/10.14744/etd.2022.33866 |
| APA | Dündar M, ORAK F, Acıpayam C, Aslan K, gök v, Cetin B, UNAL E, Klein C, Akyıldız B (2023). A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation. Erciyes Medical Journal, 45(2), 207 - 210. 10.14744/etd.2022.33866 |
| Chicago | Dündar Mehmet Akif,ORAK FİLİZ,Acıpayam Can,Aslan Kübra,gök veysel,Cetin Benhur,UNAL Ekrem,Klein Christoph,Akyıldız Basak Nur A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation. Erciyes Medical Journal 45, no.2 (2023): 207 - 210. 10.14744/etd.2022.33866 |
| MLA | Dündar Mehmet Akif,ORAK FİLİZ,Acıpayam Can,Aslan Kübra,gök veysel,Cetin Benhur,UNAL Ekrem,Klein Christoph,Akyıldız Basak Nur A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation. Erciyes Medical Journal, vol.45, no.2, 2023, ss.207 - 210. 10.14744/etd.2022.33866 |
| AMA | Dündar M,ORAK F,Acıpayam C,Aslan K,gök v,Cetin B,UNAL E,Klein C,Akyıldız B A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation. Erciyes Medical Journal. 2023; 45(2): 207 - 210. 10.14744/etd.2022.33866 |
| Vancouver | Dündar M,ORAK F,Acıpayam C,Aslan K,gök v,Cetin B,UNAL E,Klein C,Akyıldız B A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation. Erciyes Medical Journal. 2023; 45(2): 207 - 210. 10.14744/etd.2022.33866 |
| IEEE | Dündar M,ORAK F,Acıpayam C,Aslan K,gök v,Cetin B,UNAL E,Klein C,Akyıldız B "A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation." Erciyes Medical Journal, 45, ss.207 - 210, 2023. 10.14744/etd.2022.33866 |
| ISNAD | Dündar, Mehmet Akif vd. "A Fatal Case of Familial Hemophagocytic Lymphohistiocytosis Associated with Fusarium Infection and Rare Mutation". Erciyes Medical Journal 45/2 (2023), 207-210. https://doi.org/10.14744/etd.2022.33866 |
