Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia

Durmaz, Ceren Damla; Atbasoglu, E. Cem; ILGIN RUHİ, Hatice; KARABULUT, HALIL GÜRHAN; SAKA, MERAM CAN; SUCULARLI, Ceren; Gumus-Akay, Guvem

doi:10.4274/balkanmedj.galenos.2022.2022-5-90

Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia

Ceren Damla DURMAZ, (Ankara Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Ankara, Türkiye)

Halil Gürhan KARABULUT, (Hacettepe Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Ankara, Türkiye)

Meram Can SAKA, (Ankara Üniversitesi, Tıp Fakültesi, Psikiyatri Anabilim Dalı, Ankara, Türkiye)

Ceren SUCULARLI, (Hacettepe Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyoinformatik Anabilim Dalı, Ankara, Türkiye)

Guvem Gumus-Akay, (Ankara Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Ankara, Türkiye)

E. Cem ATBAŞOĞLU, (Ankara Üniversitesi, Tıp Fakültesi, Emekli Öğretim Üyesi, Psikiyatri Profesörü, Ankara, Türkiye)

Hatice Ilgın RUHİ (Ankara Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Ankara, Türkiye)

Balkan Medical Journal

3 1

Yıl: 2022 Cilt: 39 Sayı: 6 Sayfa Aralığı: 422 - 428 Metin Dili: İngilizce DOI: 10.4274/balkanmedj.galenos.2022.2022-5-90 İndeks Tarihi: 23-05-2023

Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia

Öz:

Background: RASD1 encodes Dexamethasone-induced Ras-related protein 1 (Dexras1), a protein with a critical role in signal transduction in neurons. There is a strong suspicion that dysfunction of Dexras1 might contribute to the pathogenesis of neuropsychiatric diseases. Related to its functions in intracellular signaling pathways, Dexras1 has a potential role in the etiology of schizophrenia because of its close interaction with NOS1, NOS1AP, and NMDAR, which have previously been associated with schizophrenia. Aims: To investigate the association of RASD1 variants with schizophrenia in a selected cohort from Turkey. Study Design: A case-control study. Methods: We performed targeted sequencing for the two exons, single intron, and untranslated regions of RASD1 gene in 200 individuals with schizophrenia and 100 healthy controls of Turkish origin. Results: Two rare variants, RASD1 (NM_016084.5): c.722A>T and c*31G>A were identified in individuals with schizophrenia but not in any controls. The c.722A>T was found in a single individual with schizophrenia and is a missense heterozygous variant in the second exon of RASD1, which is extremely rare in GnomAD. The other variant, c*31G>A, which was found in another individual from this schizophrenia cohort, has not been reported previously. Seven previously identified common single nucleotide polymorphisms were also detected; however, they were not significantly associated with schizophrenia in this study cohort. Conclusion: Our findings suggest that rare variants of RASD1 might be contributing to the etiopathogenesis of schizophrenia. Further studies are needed to elucidate the underlying mechanism of this association.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Durmaz C, KARABULUT H, SAKA M, SUCULARLI C, Gumus-Akay G, Atbasoglu E, ILGIN RUHİ H (2022). Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia. , 422 - 428. 10.4274/balkanmedj.galenos.2022.2022-5-90
Chicago	Durmaz Ceren Damla,KARABULUT HALIL GÜRHAN,SAKA MERAM CAN,SUCULARLI Ceren,Gumus-Akay Guvem,Atbasoglu E. Cem,ILGIN RUHİ Hatice Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia. (2022): 422 - 428. 10.4274/balkanmedj.galenos.2022.2022-5-90
MLA	Durmaz Ceren Damla,KARABULUT HALIL GÜRHAN,SAKA MERAM CAN,SUCULARLI Ceren,Gumus-Akay Guvem,Atbasoglu E. Cem,ILGIN RUHİ Hatice Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia. , 2022, ss.422 - 428. 10.4274/balkanmedj.galenos.2022.2022-5-90
AMA	Durmaz C,KARABULUT H,SAKA M,SUCULARLI C,Gumus-Akay G,Atbasoglu E,ILGIN RUHİ H Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia. . 2022; 422 - 428. 10.4274/balkanmedj.galenos.2022.2022-5-90
Vancouver	Durmaz C,KARABULUT H,SAKA M,SUCULARLI C,Gumus-Akay G,Atbasoglu E,ILGIN RUHİ H Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia. . 2022; 422 - 428. 10.4274/balkanmedj.galenos.2022.2022-5-90
IEEE	Durmaz C,KARABULUT H,SAKA M,SUCULARLI C,Gumus-Akay G,Atbasoglu E,ILGIN RUHİ H "Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia." , ss.422 - 428, 2022. 10.4274/balkanmedj.galenos.2022.2022-5-90
ISNAD	Durmaz, Ceren Damla vd. "Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia". (2022), 422-428. https://doi.org/10.4274/balkanmedj.galenos.2022.2022-5-90

APA	Durmaz C, KARABULUT H, SAKA M, SUCULARLI C, Gumus-Akay G, Atbasoglu E, ILGIN RUHİ H (2022). Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia. Balkan Medical Journal, 39(6), 422 - 428. 10.4274/balkanmedj.galenos.2022.2022-5-90
Chicago	Durmaz Ceren Damla,KARABULUT HALIL GÜRHAN,SAKA MERAM CAN,SUCULARLI Ceren,Gumus-Akay Guvem,Atbasoglu E. Cem,ILGIN RUHİ Hatice Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia. Balkan Medical Journal 39, no.6 (2022): 422 - 428. 10.4274/balkanmedj.galenos.2022.2022-5-90
MLA	Durmaz Ceren Damla,KARABULUT HALIL GÜRHAN,SAKA MERAM CAN,SUCULARLI Ceren,Gumus-Akay Guvem,Atbasoglu E. Cem,ILGIN RUHİ Hatice Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia. Balkan Medical Journal, vol.39, no.6, 2022, ss.422 - 428. 10.4274/balkanmedj.galenos.2022.2022-5-90
AMA	Durmaz C,KARABULUT H,SAKA M,SUCULARLI C,Gumus-Akay G,Atbasoglu E,ILGIN RUHİ H Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia. Balkan Medical Journal. 2022; 39(6): 422 - 428. 10.4274/balkanmedj.galenos.2022.2022-5-90
Vancouver	Durmaz C,KARABULUT H,SAKA M,SUCULARLI C,Gumus-Akay G,Atbasoglu E,ILGIN RUHİ H Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia. Balkan Medical Journal. 2022; 39(6): 422 - 428. 10.4274/balkanmedj.galenos.2022.2022-5-90
IEEE	Durmaz C,KARABULUT H,SAKA M,SUCULARLI C,Gumus-Akay G,Atbasoglu E,ILGIN RUHİ H "Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia." Balkan Medical Journal, 39, ss.422 - 428, 2022. 10.4274/balkanmedj.galenos.2022.2022-5-90
ISNAD	Durmaz, Ceren Damla vd. "Genetic Analysis of RASD1 as a Candidate Gene for Schizophrenia". Balkan Medical Journal 39/6 (2022), 422-428. https://doi.org/10.4274/balkanmedj.galenos.2022.2022-5-90