Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study
Yıl: 2023 Cilt: 12 Sayı: 1 Sayfa Aralığı: 1 - 7 Metin Dili: İngilizce DOI: 10.5336/pharmsci.2022-94331 İndeks Tarihi: 24-05-2023
Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study
Öz: Objective: Proton pump inhibitors (PPIs) are the most prescribed gastrointestinal system medications and are often pre- scribed together with other medications. This may lead to drug inter- actions. In our study, it was aimed to determine the possible interactions of PPIs. Material and Methods: This retrospective study was conducted between January 1, 2021 and March 31, 2021. A pre- scription review was conducted in a community pharmacy inİstanbul and potential drug interactions were evaluated using the Medscape and Lexicomp databases. Results: A total of 114 prescriptions were reviewed. The mean age of the patients was 55.1±14.8 years, and the mean duration of PPIs use was 5 months. It was determined that the one who prescribed PPIs the most was the family physician and it was prescribed most frequently with the indication of gastroesophageal reflux disease. The total number of interactions in the prescriptions was determined as 248 in the Medscape database and 295 in the Lex- icomp database (p<0.05). Pantoprazole was found to be the most in- teracting PPIs in both databases. Levothyroxine was found to be the drug that interacted most with PPIs in both databases. Age and dura- tion of PPIs use were found to be positively significantly correlated (p<0.05). Conclusion: In our study, the number of potential drug in- teractions in prescriptions containing PPIs was found to be high. We think that the possible interactions and duration of use of drugs used due to comorbid diseases should be considered in prescriptions con- taining PPIs.
Anahtar Kelime: Proton Pompası İnhibitörleri ile Potansiyel İlaç Etkileşimlerinin Değerlendirilmesi: Retrospektif Bir Çalışma
Öz: Amaç: Proton pompası inhibitörleri (PPI) en çok reçete edilen gastrointestinal sistem ilaçları olup, diğer ilaç gruplarıyla birlikte sık- lıkla reçete edilmektedir. Bu durum, ilaç etkile şimlerine yol açabil- mektedir. Çal ışmamızda PPI ilaçlar ının olas ı etkileşimlerinin belirlenmesi amaçlanmıştır. Gereç ve Yöntemler: Bu retrospektif ça- lışma 1 Ocak 2021 ile 31 Mart 2021 tarihleri aras ında yapılmıştır. İs- tanbul’da bir serbest eczanede reçete incelemesi yap ılmış ve ilaç etkileşimleri Medscape ve Lexicomp veri tabanları kullanılarak değer- lendirilmiştir. Bulgular: Toplam 114 reçete gözden geçirilmiştir. Has- taların yaş ortalaması 55,1±14,8 yıl, ortalama PPI kullanım süresi 5 ay olarak tespit edilmiştir. En sık PPI yazan hekimin aile hekimi olduğu ve en sık gastroözofageal reflü hastal ığı endikasyonu ile reçete edildi ği belirlenmiştir. Reçetelerdeki toplam etkileşim sayısı Medscape veri ta- banında 248, Lexicomp veri taban ında 295 olarak belirlenmi ştir (p<0,05). Pantoprazol, her iki veritabanında da en çok etkileşime giren PPI olarak bulunmuştur. Levotiroksin, her iki veri tabanında da PPI’lar ile en çok etkileşime giren ilaç olarak bulunmuştur. PPI kullanım süresi ile yaş arasında pozitif yönde anlamlı bir ilişki bulunmuştur (p<0,05). Sonuç: Çalışmamızda PPI içeren reçetelerdeki ilaç etkileşimlerinin sa- yısı yüksek bulunmuştur. PPI içeren reçetelerde komorbid hastal ıklar nedeniyle kullanılan ilaçların olası etkileşimlerinin ve kullanım sürele- rinin dikkate alınması gerektiğini düşünüyoruz.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | BAYUK B, Dede İ, tezcan s (2023). Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study. , 1 - 7. 10.5336/pharmsci.2022-94331 |
| Chicago | BAYUK BEYZA NUR,Dede İzel,tezcan songül Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study. (2023): 1 - 7. 10.5336/pharmsci.2022-94331 |
| MLA | BAYUK BEYZA NUR,Dede İzel,tezcan songül Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study. , 2023, ss.1 - 7. 10.5336/pharmsci.2022-94331 |
| AMA | BAYUK B,Dede İ,tezcan s Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study. . 2023; 1 - 7. 10.5336/pharmsci.2022-94331 |
| Vancouver | BAYUK B,Dede İ,tezcan s Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study. . 2023; 1 - 7. 10.5336/pharmsci.2022-94331 |
| IEEE | BAYUK B,Dede İ,tezcan s "Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study." , ss.1 - 7, 2023. 10.5336/pharmsci.2022-94331 |
| ISNAD | BAYUK, BEYZA NUR vd. "Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study". (2023), 1-7. https://doi.org/10.5336/pharmsci.2022-94331 |
| APA | BAYUK B, Dede İ, tezcan s (2023). Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study. Literatür Eczacılık Bilimleri Dergisi, 12(1), 1 - 7. 10.5336/pharmsci.2022-94331 |
| Chicago | BAYUK BEYZA NUR,Dede İzel,tezcan songül Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study. Literatür Eczacılık Bilimleri Dergisi 12, no.1 (2023): 1 - 7. 10.5336/pharmsci.2022-94331 |
| MLA | BAYUK BEYZA NUR,Dede İzel,tezcan songül Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study. Literatür Eczacılık Bilimleri Dergisi, vol.12, no.1, 2023, ss.1 - 7. 10.5336/pharmsci.2022-94331 |
| AMA | BAYUK B,Dede İ,tezcan s Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study. Literatür Eczacılık Bilimleri Dergisi. 2023; 12(1): 1 - 7. 10.5336/pharmsci.2022-94331 |
| Vancouver | BAYUK B,Dede İ,tezcan s Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study. Literatür Eczacılık Bilimleri Dergisi. 2023; 12(1): 1 - 7. 10.5336/pharmsci.2022-94331 |
| IEEE | BAYUK B,Dede İ,tezcan s "Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study." Literatür Eczacılık Bilimleri Dergisi, 12, ss.1 - 7, 2023. 10.5336/pharmsci.2022-94331 |
| ISNAD | BAYUK, BEYZA NUR vd. "Evaluation of Potential Drug Interactions with Proton Pump Inhibitors: A Retrospective Study". Literatür Eczacılık Bilimleri Dergisi 12/1 (2023), 1-7. https://doi.org/10.5336/pharmsci.2022-94331 |
