TY  - JOUR
TI  - Healthcare-Related HCV Genotype 4d Infections in Kayseri, Turkey
AB  - Background: The frequency of genotype 4 hepatitis C virus infection is significantly higher in a city compared to other provinces in Turkey. In this study, we aimed to investigate the epidemiology and risk factors of hepatitis C virus genotype 4 infection in Kayseri province of Turkey. Methods: A case–control study was conducted with 61 hepatitis C virus genotype 4-infected patients and 71 controls. A questionnaire was administered to the patients and controls, asking for information about the risk factors of hepatitis C virus transmission. Core/ E1 and NS5B regions of hepatitis C virus genome were amplified and sequenced by Sanger method. Phylogenetic analysis and molecular clock analysis were performed. The risk was determined by calculating the odds ratio and 95% CI. Logistic regression analysis was per- formed to determine the effect of risk factors by controlling for confounding variables. Results: Kayseri isolates were closely related to type 4d sequences but formed a separate cluster. According to the molecular clock analysis, hepatitis C virus genotype 4d entered Kayseri province probably between 1941 and 1988. Blood transfusion and surgical inter- vention were found to be significant risk factors for the infection. Conclusion: Epidemiological data showed that hepatitis C virus genotype 4d infections are significantly associated with unsafe medical procedures.
AU  - Gürsoy, Sebnem
AU  - Atalay, Mustafa Altay
AU  - gökahmetoğlu, selma
AU  - Polat, Ceylan
AU  - Can Sezgin, Gülten
AU  - Ergör, Gül
AU  - Aygen, Bilgehan
AU  - Abacioglu, Hakan
DO  - 10.5152/tjg.2022.21822
PY  - 2022
JO  - Turkish Journal of Gastroenterology
VL  - 33
IS  - 11
SN  - 1300-4948
SP  - 964
EP  - 970
DB  - TRDizin
UR  - http://search/yayin/detay/1175259
ER  -