In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey

Background: People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting. Methods: We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 patients were included in the study among which 250 were PWID and 2463 were non-PWID. Besides patient characteristics, treatment response, follow-up, and side effects of treatment were also analyzed. Results: Genotype 1a and 3 were more prevalent in PWID-infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naïve patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow-up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%). Conclusion: Direct-acting antivirals were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization’s objective of eliminating viral hepatitis.

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APA	Sarıgül F, User U, Didem sarı N, Kurtaran B, ONLEN Y, Şenateş E, Gunduz A, zerdali e, KARSEN H, Batirel A, KARAALİ R, GÜNER R, Yamazhan T, köse ş, Erben N, Ince N, Koksal I, Oztoprak N, Yörük G, komur s, Bal T, Yıldız Kaya S, bozkurt i, Gunal O, YILDIZ I, İNAN D, Barut S, NAMIDURU M, Tosun S, Türker K, Sener A, hizel k, Baykam N, Duygu F, Bodur H, Can G, GÜL H, SAĞMAK TARTAR A, Celebi G, Sunnetcioglu M, KARABAY O, kumbasar karaosmanoglu h, SIRMATEL F, Tabak F (2022). In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey. , 971 - 978. 10.5152/tjg.2022.21834
Chicago	Sarıgül Figen,User Ulku,Didem sarı Nagehan,Kurtaran Behice,ONLEN YÜSÜF,Şenateş Ebubekir,Gunduz Alper,zerdali esra,KARSEN HASAN,Batirel Ayse,KARAALİ Rıdvan,GÜNER RAHMET,Yamazhan Tansu,köse şükran,Erben Nurettin,Ince Nevin,Koksal Iftihar,Oztoprak Nefise,Yörük Gülşen,komur suheyla,Bal Tayibe,Yıldız Kaya Sibel,bozkurt ilkay,Gunal Ozgur,YILDIZ ILKNUR ESEN,İNAN DİLARA,Barut Sener,NAMIDURU Mustafa,Tosun Selma,Türker Kamuran,Sener Alper,hizel kenan,Baykam Nurcan,Duygu Fazilet,Bodur Hurrem,Can Güray,GÜL Hanefi Cem,SAĞMAK TARTAR Ayşe,Celebi Guven,Sunnetcioglu Mahmut,KARABAY OĞUZ,kumbasar karaosmanoglu hayat,SIRMATEL FATMA,Tabak Fehmi In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey. (2022): 971 - 978. 10.5152/tjg.2022.21834
MLA	Sarıgül Figen,User Ulku,Didem sarı Nagehan,Kurtaran Behice,ONLEN YÜSÜF,Şenateş Ebubekir,Gunduz Alper,zerdali esra,KARSEN HASAN,Batirel Ayse,KARAALİ Rıdvan,GÜNER RAHMET,Yamazhan Tansu,köse şükran,Erben Nurettin,Ince Nevin,Koksal Iftihar,Oztoprak Nefise,Yörük Gülşen,komur suheyla,Bal Tayibe,Yıldız Kaya Sibel,bozkurt ilkay,Gunal Ozgur,YILDIZ ILKNUR ESEN,İNAN DİLARA,Barut Sener,NAMIDURU Mustafa,Tosun Selma,Türker Kamuran,Sener Alper,hizel kenan,Baykam Nurcan,Duygu Fazilet,Bodur Hurrem,Can Güray,GÜL Hanefi Cem,SAĞMAK TARTAR Ayşe,Celebi Guven,Sunnetcioglu Mahmut,KARABAY OĞUZ,kumbasar karaosmanoglu hayat,SIRMATEL FATMA,Tabak Fehmi In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey. , 2022, ss.971 - 978. 10.5152/tjg.2022.21834
AMA	Sarıgül F,User U,Didem sarı N,Kurtaran B,ONLEN Y,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Oztoprak N,Yörük G,komur s,Bal T,Yıldız Kaya S,bozkurt i,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Bodur H,Can G,GÜL H,SAĞMAK TARTAR A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey. . 2022; 971 - 978. 10.5152/tjg.2022.21834
Vancouver	Sarıgül F,User U,Didem sarı N,Kurtaran B,ONLEN Y,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Oztoprak N,Yörük G,komur s,Bal T,Yıldız Kaya S,bozkurt i,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Bodur H,Can G,GÜL H,SAĞMAK TARTAR A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey. . 2022; 971 - 978. 10.5152/tjg.2022.21834
IEEE	Sarıgül F,User U,Didem sarı N,Kurtaran B,ONLEN Y,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Oztoprak N,Yörük G,komur s,Bal T,Yıldız Kaya S,bozkurt i,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Bodur H,Can G,GÜL H,SAĞMAK TARTAR A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F "In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey." , ss.971 - 978, 2022. 10.5152/tjg.2022.21834
ISNAD	Sarıgül, Figen vd. "In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey". (2022), 971-978. https://doi.org/10.5152/tjg.2022.21834

APA	Sarıgül F, User U, Didem sarı N, Kurtaran B, ONLEN Y, Şenateş E, Gunduz A, zerdali e, KARSEN H, Batirel A, KARAALİ R, GÜNER R, Yamazhan T, köse ş, Erben N, Ince N, Koksal I, Oztoprak N, Yörük G, komur s, Bal T, Yıldız Kaya S, bozkurt i, Gunal O, YILDIZ I, İNAN D, Barut S, NAMIDURU M, Tosun S, Türker K, Sener A, hizel k, Baykam N, Duygu F, Bodur H, Can G, GÜL H, SAĞMAK TARTAR A, Celebi G, Sunnetcioglu M, KARABAY O, kumbasar karaosmanoglu h, SIRMATEL F, Tabak F (2022). In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey. Turkish Journal of Gastroenterology, 33(11), 971 - 978. 10.5152/tjg.2022.21834
Chicago	Sarıgül Figen,User Ulku,Didem sarı Nagehan,Kurtaran Behice,ONLEN YÜSÜF,Şenateş Ebubekir,Gunduz Alper,zerdali esra,KARSEN HASAN,Batirel Ayse,KARAALİ Rıdvan,GÜNER RAHMET,Yamazhan Tansu,köse şükran,Erben Nurettin,Ince Nevin,Koksal Iftihar,Oztoprak Nefise,Yörük Gülşen,komur suheyla,Bal Tayibe,Yıldız Kaya Sibel,bozkurt ilkay,Gunal Ozgur,YILDIZ ILKNUR ESEN,İNAN DİLARA,Barut Sener,NAMIDURU Mustafa,Tosun Selma,Türker Kamuran,Sener Alper,hizel kenan,Baykam Nurcan,Duygu Fazilet,Bodur Hurrem,Can Güray,GÜL Hanefi Cem,SAĞMAK TARTAR Ayşe,Celebi Guven,Sunnetcioglu Mahmut,KARABAY OĞUZ,kumbasar karaosmanoglu hayat,SIRMATEL FATMA,Tabak Fehmi In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey. Turkish Journal of Gastroenterology 33, no.11 (2022): 971 - 978. 10.5152/tjg.2022.21834
MLA	Sarıgül Figen,User Ulku,Didem sarı Nagehan,Kurtaran Behice,ONLEN YÜSÜF,Şenateş Ebubekir,Gunduz Alper,zerdali esra,KARSEN HASAN,Batirel Ayse,KARAALİ Rıdvan,GÜNER RAHMET,Yamazhan Tansu,köse şükran,Erben Nurettin,Ince Nevin,Koksal Iftihar,Oztoprak Nefise,Yörük Gülşen,komur suheyla,Bal Tayibe,Yıldız Kaya Sibel,bozkurt ilkay,Gunal Ozgur,YILDIZ ILKNUR ESEN,İNAN DİLARA,Barut Sener,NAMIDURU Mustafa,Tosun Selma,Türker Kamuran,Sener Alper,hizel kenan,Baykam Nurcan,Duygu Fazilet,Bodur Hurrem,Can Güray,GÜL Hanefi Cem,SAĞMAK TARTAR Ayşe,Celebi Guven,Sunnetcioglu Mahmut,KARABAY OĞUZ,kumbasar karaosmanoglu hayat,SIRMATEL FATMA,Tabak Fehmi In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey. Turkish Journal of Gastroenterology, vol.33, no.11, 2022, ss.971 - 978. 10.5152/tjg.2022.21834
AMA	Sarıgül F,User U,Didem sarı N,Kurtaran B,ONLEN Y,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Oztoprak N,Yörük G,komur s,Bal T,Yıldız Kaya S,bozkurt i,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Bodur H,Can G,GÜL H,SAĞMAK TARTAR A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey. Turkish Journal of Gastroenterology. 2022; 33(11): 971 - 978. 10.5152/tjg.2022.21834
Vancouver	Sarıgül F,User U,Didem sarı N,Kurtaran B,ONLEN Y,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Oztoprak N,Yörük G,komur s,Bal T,Yıldız Kaya S,bozkurt i,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Bodur H,Can G,GÜL H,SAĞMAK TARTAR A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey. Turkish Journal of Gastroenterology. 2022; 33(11): 971 - 978. 10.5152/tjg.2022.21834
IEEE	Sarıgül F,User U,Didem sarı N,Kurtaran B,ONLEN Y,Şenateş E,Gunduz A,zerdali e,KARSEN H,Batirel A,KARAALİ R,GÜNER R,Yamazhan T,köse ş,Erben N,Ince N,Koksal I,Oztoprak N,Yörük G,komur s,Bal T,Yıldız Kaya S,bozkurt i,Gunal O,YILDIZ I,İNAN D,Barut S,NAMIDURU M,Tosun S,Türker K,Sener A,hizel k,Baykam N,Duygu F,Bodur H,Can G,GÜL H,SAĞMAK TARTAR A,Celebi G,Sunnetcioglu M,KARABAY O,kumbasar karaosmanoglu h,SIRMATEL F,Tabak F "In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey." Turkish Journal of Gastroenterology, 33, ss.971 - 978, 2022. 10.5152/tjg.2022.21834
ISNAD	Sarıgül, Figen vd. "In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey". Turkish Journal of Gastroenterology 33/11 (2022), 971-978. https://doi.org/10.5152/tjg.2022.21834