TY  - JOUR
TI  - In a Real-Life Setting, Direct-Acting Antivirals to People Who Inject Drugs with Chronic Hepatitis C in Turkey
AB  - Background: People who inject drugs (PWID) should be treated in order to eliminate hepatitis C virus in the world. The aim of this study was to compare direct-acting antivirals treatment of hepatitis C virus for PWID and non-PWID in a real-life setting. Methods: We performed a prospective, non-randomized, observational multicenter cohort study in 37 centers. All patients treated with direct-acting antivirals between April 1, 2017, and February 28, 2019, were included. In total, 2713 patients were included in the study among which 250 were PWID and 2463 were non-PWID. Besides patient characteristics, treatment response, follow-up, and side effects of treatment were also analyzed. Results: Genotype 1a and 3 were more prevalent in PWID-infected patients (20.4% vs 9.9% and 46.8% vs 5.3%). The number of naïve patients was higher in PWID (90.7% vs 60.0%), while the number of patients with cirrhosis was higher in non-PWID (14.1% vs 3.7%). The loss of follow-up was higher in PWID (29.6% vs 13.6%). There was no difference in the sustained virologic response at 12 weeks after treatment (98.3% vs 98.4%), but the end of treatment response was lower in PWID (96.2% vs 99.0%). In addition, the rate of treatment completion was lower in PWID (74% vs 94.4%). Conclusion: Direct-acting antivirals were safe and effective in PWID. Primary measures should be taken to prevent the loss of follow-up and poor adherence in PWID patients in order to achieve World Health Organization’s objective of eliminating viral hepatitis.
AU  - İNAN, DİLARA
AU  - Duygu, Fazilet
AU  - GÜNER, RAHMET
AU  - Sener, Alper
AU  - Ince, Nevin
AU  - Tabak, Fehmi
AU  - hizel, kenan
AU  - Gunduz, Alper
AU  - komur, suheyla
AU  - YILDIZ, ILKNUR ESEN
AU  - KARAALİ, Rıdvan
AU  - bozkurt, ilkay
AU  - Celebi, Guven
AU  - Oztoprak, Nefise
AU  - Yıldız Kaya, Sibel
AU  - Sarıgül, Figen
AU  - User, Ulku
AU  - Şenateş, Ebubekir
AU  - Sunnetcioglu, Mahmut
AU  - KARABAY, OĞUZ
AU  - kumbasar karaosmanoglu, hayat
AU  - SIRMATEL, FATMA
AU  - Didem sarı, Nagehan
AU  - Kurtaran, Behice
AU  - ONLEN, YÜSÜF
AU  - zerdali, esra
AU  - KARSEN, HASAN
AU  - Batirel, Ayse
AU  - Yamazhan, Tansu
AU  - köse, şükran
AU  - Erben, Nurettin
AU  - Koksal, Iftihar
AU  - Yörük, Gülşen
AU  - Bal, Tayibe
AU  - Gunal, Ozgur
AU  - Barut, Sener
AU  - NAMIDURU, Mustafa
AU  - Tosun, Selma
AU  - Türker, Kamuran
AU  - Baykam, Nurcan
AU  - Bodur, Hurrem
AU  - Can, Güray
AU  - GÜL, Hanefi Cem
AU  - SAĞMAK TARTAR, Ayşe
DO  - 10.5152/tjg.2022.21834
PY  - 2022
JO  - Turkish Journal of Gastroenterology
VL  - 33
IS  - 11
SN  - 1300-4948
SP  - 971
EP  - 978
DB  - TRDizin
UR  - http://search/yayin/detay/1175267
ER  -