Yıl: 2023 Cilt: 15 Sayı: 1 Sayfa Aralığı: 70 - 76 Metin Dili: İngilizce DOI: 10.4274/jcrpe.galenos.2022.2022-5-18 İndeks Tarihi: 25-05-2023

Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease

Öz:
Objective: It has been reported that bone mineral density (BMD) is decreased in children with Celiac disease (CD) compared to their healthy peers. The aim of this study was to reveal possible risk factors for low BMD in Turkish children newly diagnosed with CD. Methods: Eighty-six patients (2-18 years old) with CD were included in this retrospective study. The relationship between their lumbar BMD z-scores calculated according to their chronological age (CA) and height age (HA) and their clinical, laboratory [biochemical parameters, tissue transglutaminase antibody-IgA (TTGA) levels, human leukocyte antigen (HLA) types] and histopathological parameters were evaluated. Results: The mean age of the patients at diagnosis was 8.06±4.08 years. The BMD z-score CA was ≤-2 standard deviation (SD) in 26.7% of the patients. The BMD z-score HA was ≤-2 SD in 12.8% of the patients. The BMD z-score HA only correlated with their age at diagnosis of CD (rs value 0.269). However, there was no statistically difference between the BMD z-score HA >-2 SD and ≤-2 SD subgroups regarding their clinical, laboratory and histopathological parameters. Conclusion: Low BMD is common in children with newly diagnosed CD. Age at diagnosis, gender, body size, Celiac symptoms, biochemical parameters, TTGA level, HLA type, and histopathological stage had no predictive values in terms of low BMD in this patient group.
Anahtar Kelime: Low bone mineral density Celiac disease children risk factors

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Ravikumara M, Tuthill DP, Jenkins HR. The changing clinical presentation of coeliac disease. Arch Dis Child 2006;91:969-971. Epub 2006 Aug 3
  • Troncone R, Jabri B. Celiac disease and gluten sensitivity. J Intern Med 2011;269:582-590.
  • Popp A, Mäki M. Changing pattern of childhood celiac disease epidemiology: contributing factors. Front Pediatr 2019;29;7:357.
  • Kalayci AG, Kansu A, Girgin N, Kucuk O, Aras G. Bone mineral density and importance of a gluten-free diet in patients with celiac disease in childhood. Pediatrics 2001;108:89.
  • Mora S, Barera G, Beccio S, Menni L, Proverbio MC, Bianchi C, Chiumello G. A prospective, longitudinal study of the long-term effect of treatment on bone density in children with celiac disease. J Pediatr 2001;139:516-521.
  • Tau C, Mautalen C, De Rosa S, Roca A, Valenzuela X. Bone mineral density in children with celiac disease. Eur J Clin Nutr 2006;60:358- 363.
  • Zanchi C, Di Leo G, Ronfani L, Martelossi S, Not T, Ventura A. Bone metabolism in celiac disease. J Pediatr 2008;153:262-265. Epub 2008 Apr 14
  • Selby PL, Davies M, Adams JE, Mawer EB. Bone loss in celiac disease is related to secondary hyperparathyroidism. J Bone Miner Res 1999;14:652-657.
  • Margoni D, Chouliaras G, Duscas G, Voskaki I, Voutsas N, Papadopoulou A, Panayiotou J, Roma E. Bone health in children with celiac disease J Clin Res Pediatr Endocrinol 2023;15(1):62-68 assessed by dual x-ray absorptiometry: effect of gluten-free diet and predictive value of serum biochemical indices.
  • Choudhary G, Gupta RK, Beniwal J. Bone Mineral Density in Celiac Disease. Indian J Pediatr 2017;84:344-348. Epub 2016 Dec 27
  • Turner J, Pellerin G, Mager D. Prevalence of metabolic bone disease in children with celiac disease is independent of symptoms at diagnosis. J Pediatr Gastroenterol Nutr 2009;49:589-593.
  • Tuna Kırsaçlıoğlu C, Kuloğlu Z, Tanca A, Küçük NÖ, Aycan Z, Öcal G, Ensari A, Kalaycı AG, Girgin N. Bone mineral density and growth in children with coeliac disease on a gluten free-diet. Turk J Med Sci 2016;46:1816-1821.
  • Webster J, Vajravelu ME, Choi C, Zemel B, Verma R. Prevalence of and Risk Factors for Low Bone Mineral Density in Children With Celiac Disease. Clin Gastroenterol Hepatol 2019;17:1509-1514. Epub 2018 Oct 26
  • Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R, Troncone R, Giersiepen K, Branski D, Catassi C, Lelgeman M, Mäki M, Ribes-Koninckx C, Ventura A, Zimmer KP; ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease. J Pediatr Gastroenterol Nutr 2012;54:136-160.
  • Oberhuber G, Granditsch G, Vogelsang H. The histopathology of coeliac disease: time for a standardized reports cheme for pathologists. Eur J Gastroenterol Hepatol 1999;11:1185-1194.
  • Neyzi O, Bundak R, Gökçay G, Günöz H, Furman A, Darendeliler F, Baş F. Reference Values for Weight, Height, Head Circumference, and Body Mass Index in Turkish Children. J Clin Res Pediatr Endocrinol 2015;7:280-293.
  • Demir K, Özen S, Konakçı E, Aydın M, Darendeliler F. A Comprehensive Online Calculator for Pediatric Endocrinologists: ÇEDD Çözüm/TPEDS Metrics. J Clin Res Pediatr Endocrinol 2017;9:182-184. Epub 2017 Apr 26
  • Goksen D, Darcan S, Coker M, Kose T. Bone mineral density of healthy Turkish children and adolescents. J Clin Densitom 2006;9:84-90. Epub 2006 Mar 27
  • Shuhart CR, Yeap SS, Anderson PA, Jankowski LG, Lewiecki EM, Morse LR, Rosen HN, Weber DR, Zemel BS, Shepherd JA. Executive Summary of the 2019 ISCD Position Development Conference on Monitoring Treatment, DXA Cross-calibration and Least Significant Change, Spinal Cord Injury, Peri-prosthetic and Orthopedic Bone Health, Transgender Medicine, and Pediatrics. J Clin Densitom 2019;22:453-471. Epub 2019 Jul 5
  • Gordon CM, Leonard MB, Zemel BS; International Society for Clinical Densitometry. 2013 Pediatric Position Development Conference: executive summary and reflections. J Clin Densitom 2014;17:219-224. Epub 2014 Mar 20
  • Rubio-Tapia A, Murray JA. Liver involvement in celiac disease. Minerva Med 2008;99:595-604.
  • Lewis NR, Scott BB. Should patients with coeliac disease have their bone mineral density measured? Eur J Gastroenterol Hepatol 2005;17:1065- 1070.
  • García-Manzanares A, Tenias JM, Lucendo AJ. Bone mineral density directly correlates with duodenal Marsh stage in newly diagnosed adult celiac patients. Scand J Gastroenterol 2012;47:927-936. Epub 2012 May 16
  • Posthumus L, Al-Toma A. Duodenal histopathology and laboratory deficiencies related to bone metabolism in coeliac disease. Eur J Gastroenterol Hepatol 2017;29:897-903.
APA çamtosun e, VAROL F, Güngör Ş, Selimoglu M (2023). Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease. , 70 - 76. 10.4274/jcrpe.galenos.2022.2022-5-18
Chicago çamtosun emine,VAROL FATMA,Güngör Şükrü,Selimoglu Mukadder Ayse Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease. (2023): 70 - 76. 10.4274/jcrpe.galenos.2022.2022-5-18
MLA çamtosun emine,VAROL FATMA,Güngör Şükrü,Selimoglu Mukadder Ayse Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease. , 2023, ss.70 - 76. 10.4274/jcrpe.galenos.2022.2022-5-18
AMA çamtosun e,VAROL F,Güngör Ş,Selimoglu M Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease. . 2023; 70 - 76. 10.4274/jcrpe.galenos.2022.2022-5-18
Vancouver çamtosun e,VAROL F,Güngör Ş,Selimoglu M Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease. . 2023; 70 - 76. 10.4274/jcrpe.galenos.2022.2022-5-18
IEEE çamtosun e,VAROL F,Güngör Ş,Selimoglu M "Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease." , ss.70 - 76, 2023. 10.4274/jcrpe.galenos.2022.2022-5-18
ISNAD çamtosun, emine vd. "Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease". (2023), 70-76. https://doi.org/10.4274/jcrpe.galenos.2022.2022-5-18
APA çamtosun e, VAROL F, Güngör Ş, Selimoglu M (2023). Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease. Journal of Clinical Research in Pediatric Endocrinology, 15(1), 70 - 76. 10.4274/jcrpe.galenos.2022.2022-5-18
Chicago çamtosun emine,VAROL FATMA,Güngör Şükrü,Selimoglu Mukadder Ayse Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease. Journal of Clinical Research in Pediatric Endocrinology 15, no.1 (2023): 70 - 76. 10.4274/jcrpe.galenos.2022.2022-5-18
MLA çamtosun emine,VAROL FATMA,Güngör Şükrü,Selimoglu Mukadder Ayse Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease. Journal of Clinical Research in Pediatric Endocrinology, vol.15, no.1, 2023, ss.70 - 76. 10.4274/jcrpe.galenos.2022.2022-5-18
AMA çamtosun e,VAROL F,Güngör Ş,Selimoglu M Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease. Journal of Clinical Research in Pediatric Endocrinology. 2023; 15(1): 70 - 76. 10.4274/jcrpe.galenos.2022.2022-5-18
Vancouver çamtosun e,VAROL F,Güngör Ş,Selimoglu M Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease. Journal of Clinical Research in Pediatric Endocrinology. 2023; 15(1): 70 - 76. 10.4274/jcrpe.galenos.2022.2022-5-18
IEEE çamtosun e,VAROL F,Güngör Ş,Selimoglu M "Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease." Journal of Clinical Research in Pediatric Endocrinology, 15, ss.70 - 76, 2023. 10.4274/jcrpe.galenos.2022.2022-5-18
ISNAD çamtosun, emine vd. "Factors Associated with Low Bone Mineral Density at the Time of Diagnosis in Children with Celiac Disease". Journal of Clinical Research in Pediatric Endocrinology 15/1 (2023), 70-76. https://doi.org/10.4274/jcrpe.galenos.2022.2022-5-18