BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ

Tuğba GÜNBATAN, (Gazi Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Ankara, Türkiye)
ECE SALİHOĞLU, (Gazi Üniversitesi, Eczacılık Fakültesi, Farmasötik Biyokimya Anabilim Dalı, Ankara, Türkiye)
İlhan GÜRBÜZ, (Gazi Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Ankara, Türkiye)
Sevgi YARDIM AKAYDIN, (Gazi Üniversitesi, Eczacılık Fakültesi, Farmasötik Biyokimya Anabilim Dalı, Ankara, Türkiye)
Galip AKAYDIN (Hacettepe Üniversitesi, Eğitim Fakültesi, Matematik ve Fen Bilimleri Eğitimi Bölümü, Ankara, Türkiye)
Ankara Üniversitesi Eczacılık Fakültesi Dergisi
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Yıl: 2023 Cilt: 47 Sayı: 2 Sayfa Aralığı: 637 - 649 Metin Dili: Türkçe DOI: 10.33483/jfpau.1211616 İndeks Tarihi: 26-05-2023

BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ

Öz:
Amaç: Bu araştırmada Düzce'de halk ilacı olarak kullanılan yedi bitkinin [Dioscorea communis (L.) Caddick & Wilkin, Mentha longifolia (L.) L. subsp. typhoides (Briq.) Harley, Origanum vulgare L., Rubus ulmifolius Schott, Salvia tomentosa Mill., Thymus longicaulis C.Presl subsp. longicaulis, Trachystemon orientalis (L.) D. Don] üreaz, kimotripsin inhibe edici ve antioksidan aktivitelerinin tespiti amaçlanmıştır. Gereç ve Yöntem: Bu amaçla bitkilerden metanol ve su ekstreleri hazırlanmıştır. Daha sonra in vitro üreaz ve kimotripsin inhibitör aktiviteleri belirlenmiştir. Ayrıca farklı yöntemlerle antioksidan aktiviteleri (ABTS, CUPRAC, DPPH), toplam fenol ve flavonoit içerikleri de tespit edilmiştir. Sonuç ve Tartışma: D. communis, O. vulgare, S. tomentosa ve T. longicaulis'in metanol ekstreleri orta düzeyde üreaz inhibitör aktivite (%34.26 ile %44.94 aralığında inhibisyon) gösterirken, diğerlerinde aktivite daha düşük bulunmuştur. En güçlü kimotripsin inhibe edici aktivite R. ulmifolius metanol ekstresi ve T. orientalis su ekstresinde gözlenmiştir (IC50 değerleri sırasıyla 65.32 ve 78.65µg/ml). Genel olarak, çalışılan bitkiler yüksek fenol ve flavonoit içeriklerine uygun olarak yüksek antioksidan aktivite göstermiştir. Sonuç olarak R. ulmifolius ve T. orientalis kuvvetli kimotripsin inhibe edici aktiviteleri ile dikkat çekmiştir. Bu bitkilerin kimotripsin aktivitesi üzerinde daha kapsamlı çalışmaların yapılması gerekmektedir.
Anahtar Kelime: Antioksidan halk ilacı kimotripsin Rubus ulmifolius üreaz

CHYMOTRYPSIN, UREASE INHIBITORY AND ANTIOXIDANT ACTIVITIES OF SOME DÜZCE FOLK MEDICINES

Öz:
Objective: In this study, determining the urease, chymotrypsin inhibitory and antioxidant activities of seven plants [Dioscorea communis (L.) Caddick & Wilkin, Mentha longifolia (L.) L. subsp. typhoides (Briq.) Harley, Origanum vulgare L., Rubus ulmifolius Schott, Salvia tomentosa Mill., Thymus longicaulis C.Presl subsp. longicaulis, Trachystemon orientalis (L.) D. Don] used as folk medicine in Düzce was aimed. Material and Method: For this purpose, methanol and water extracts were prepared, then in vitro urease and chymotrypsin inhibitory activities were determined. Antioxidant activities (ABTS, CUPRAC, DPPH), total phenol and flavonoid contents were also determined. Result and Discussion: While D. communis, O. vulgare, S. tomentosa and T. longicaulis methanol extracts showed moderate urease inhibitory activity (inhibitions between 34.26% and 44.94%), the activity was lower in others. The strongest chymotrypsin inhibitory activities were observed in R. ulmifolius methanol extract and T. orientalis water extract (IC50: 65.32 and 78.65 µg/ml, respectively). In general, the studied plants showed high antioxidant activity in accordance with their high phenol and flavonoid contents. In conclusion, R. ulmifolius and T. orientalis attracted attention with strong chymotrypsin inhibitory activities. More comprehensive studies on the chymotrypsin activity of these plants are required.
Anahtar Kelime: Antioxidant chymotrypsin folk medicine Rubus ulmifolius urease

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Günbatan T, Miser Salihoğlu E, GÜRBÜZ İ, AKAYDIN S, Akaydın G (2023). BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ. , 637 - 649. 10.33483/jfpau.1211616
Chicago Günbatan Tuğba,Miser Salihoğlu Ece,GÜRBÜZ İLHAN,AKAYDIN Sevgi,Akaydın Galip BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ. (2023): 637 - 649. 10.33483/jfpau.1211616
MLA Günbatan Tuğba,Miser Salihoğlu Ece,GÜRBÜZ İLHAN,AKAYDIN Sevgi,Akaydın Galip BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ. , 2023, ss.637 - 649. 10.33483/jfpau.1211616
AMA Günbatan T,Miser Salihoğlu E,GÜRBÜZ İ,AKAYDIN S,Akaydın G BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ. . 2023; 637 - 649. 10.33483/jfpau.1211616
Vancouver Günbatan T,Miser Salihoğlu E,GÜRBÜZ İ,AKAYDIN S,Akaydın G BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ. . 2023; 637 - 649. 10.33483/jfpau.1211616
IEEE Günbatan T,Miser Salihoğlu E,GÜRBÜZ İ,AKAYDIN S,Akaydın G "BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ." , ss.637 - 649, 2023. 10.33483/jfpau.1211616
ISNAD Günbatan, Tuğba vd. "BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ". (2023), 637-649. https://doi.org/10.33483/jfpau.1211616
APA Günbatan T, Miser Salihoğlu E, GÜRBÜZ İ, AKAYDIN S, Akaydın G (2023). BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 47(2), 637 - 649. 10.33483/jfpau.1211616
Chicago Günbatan Tuğba,Miser Salihoğlu Ece,GÜRBÜZ İLHAN,AKAYDIN Sevgi,Akaydın Galip BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi 47, no.2 (2023): 637 - 649. 10.33483/jfpau.1211616
MLA Günbatan Tuğba,Miser Salihoğlu Ece,GÜRBÜZ İLHAN,AKAYDIN Sevgi,Akaydın Galip BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, vol.47, no.2, 2023, ss.637 - 649. 10.33483/jfpau.1211616
AMA Günbatan T,Miser Salihoğlu E,GÜRBÜZ İ,AKAYDIN S,Akaydın G BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2023; 47(2): 637 - 649. 10.33483/jfpau.1211616
Vancouver Günbatan T,Miser Salihoğlu E,GÜRBÜZ İ,AKAYDIN S,Akaydın G BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2023; 47(2): 637 - 649. 10.33483/jfpau.1211616
IEEE Günbatan T,Miser Salihoğlu E,GÜRBÜZ İ,AKAYDIN S,Akaydın G "BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ." Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 47, ss.637 - 649, 2023. 10.33483/jfpau.1211616
ISNAD Günbatan, Tuğba vd. "BAZI DÜZCE HALK İLAÇLARININ KİMOTRİPSİN, ÜREAZ İNHİBE EDİCİ VE ANTİOKSİDAN AKTİVİTELERİ". Ankara Üniversitesi Eczacılık Fakültesi Dergisi 47/2 (2023), 637-649. https://doi.org/10.33483/jfpau.1211616
Sayfa Oluşturulma Tarihi
24-04-2024 7:28

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