COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES

AYDIN, Bilge; YUCA, Hafize; Demircan, Hakkı Cem; Nobarirezaeyeh, Mohaddeseh; Göger, Gamze; KARAKAYA, Songül; Güvenalp, Zühal; Önal, Mehmet; TEKMAN, Enes; CIVAS, AYSE

doi:10.33483/jfpau.1218845

COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES

Hafize YUCA, (Atatürk Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Erzurum, Türkiye)

Hakkı Cem DEMİRCAN, (Atatürk Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Erzurum, Türkiye)

Bilge AYDIN, (Erzincan Binali Yıldırım Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Erzincan, Türkiye)

Mehmet ÖNAL, (Doğu Anadolu Ormancılık Araştırma Enstitüsü, Erzurum, Türkiye)

Enes TEKMAN, (Atatürk Üniversitesi, Eczacılık Fakültesi, Farmasötik Botanik Anabilim Dalı, Erzurum, Türkiye)

Ayşe CİVAŞ, (Iğdır Üniversitesi, Tuzluca Meslek Yüksekokulu, Eczacılık Hizmetleri Anabilim Dalı, Iğdır, Türkiye)

Mohaddeseh NOBARİREZAEYEH, (Atatürk Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Erzurum, Türkiye)

Gamze GÖGER, (Trakya Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Edirne, Türkiye)

Songül KARAKAYA, (Atatürk Üniversitesi, Eczacılık Fakültesi, Farmasötik Botanik Anabilim Dalı, Erzurum, Türkiye)

Zühal Güvenalp (Atatürk Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Erzurum, Türkiye)

Ankara Üniversitesi Eczacılık Fakültesi Dergisi

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Yıl: 2023 Cilt: 47 Sayı: 2 Sayfa Aralığı: 650 - 666 Metin Dili: İngilizce DOI: 10.33483/jfpau.1218845 İndeks Tarihi: 26-05-2023

COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES

Öz:

Objective: Qualitative and quantitative determination of catechin in fruits of J. communis var. saxatilis, J. oxycedrus subsp. oxycedrus, P. spinosa, and P. cerasifera was analyzed by LC-MS/MS using standards. Antidiabetic, antimicrobial, and antioxidant activities of fruit and cone extracts of these plants were evaluated. Qualitative analysis of secondary metabolites was also done. Material and Method: Antimicrobial activity was done with MIC. ABTS·+ and DPPH• scavenging activies were used antioxidant activity. α-Amylase and α-glucosidase inhibition assays were done for antidiabetic activity. Result and Discussion: JCS (IC50 = 578 ± 20 μg/ml), JOO (IC50 = 3706 ± 52 μg/ml), and PS (IC50 = 313 ± 7 μg/ml) extracts were observed to show a higher activity than acarbose (IC50 = 4061 ± 146 μg/ml). J. communis var. saxatilis fruit extract was observed with MIC values between (312.5 -2500 µg/ml) against all microorganisms. JCS extract has the highest phenolic composition and JOO has the lowest phenolic composition (µg GAE/ mg extract). JCS extract indicated the highest antioxidant activity. It was determined that plant containing the highest catechin (1173.3±5.77 ng/ml) and epigallocatechin (208±7.21 ng/ml) was JCS. In this research, it can be said that JCS with the highest tannin content shows the highest effects.

Anahtar Kelime: Antidiabetic antimicrobial catechic Juniperus Prunus

İKİ JUNİPERUS VE PRUNUS TÜRÜNÜN BAZI BİYOLOJİK AKTİVİTELERİNİN VE KATEŞİN TANEN İÇERİKLERİNİN KARŞILAŞTIRILMASI

Öz:

Amaç: J. communis var. saxatilis, J. oxycedrus subsp. oxycedrus, P. spinosa, ve P. cerasifera meyvelerinde standartlar kullanılarak LC-MS/MS ile analiz edilmiştir. Bitkilerin meyve ve kozalak ekstrelerinin antidiyabetik, antimikrobiyal ve antioksidan aktiviteleri değerlendirilmiştir. Sekonder metabolitlerin kalitatif analizi de yapılmıştır. Gereç ve Yöntem: MIC ile antimikrobiyal aktivite yapıldı. ABTS·+ ve DPPH• süpürücü testler antioksidan aktiviteler için kullanılmıştır. α-Amilaz ve α-glukosidaz inhibisyon testleri antidiyabetik aktivite için kullanılmıştır. Sonuç ve Tartışma: JCS (IC50 = 578 ± 20 μg/ml), JOO (IC50 = 3706 ± 52 μg/ml) ve PS (IC50 = 313 ± 7 μg/ml) ekstraktlarının akarbozdan (IC50 = 4061 ± 146 μg/ml) daha yüksek aktivite gösterdiği gözlemlenmiştir. Juniperus communis var. saxatilis meyve ekstresi tüm mikroorganizmalara karşı (312.5 -2500 µg/ml) arasında MİK değerleri göstermiştir. JCS en yüksek fenolik bileşime ve JOO en düşük fenolik bileşime sahiptir (µg GAE/ mg ekstrakt). JCS ekstresi en yüksek antioksidan aktiviteyi göstermiştir. En yüksek kateşin (1173.3±5.77 ng/ml) ve epigallokateşin (208±7.21 ng/ml) içeren bitki JCS’dir. Bu araştırmada en yüksek tanen içeriğine sahip JCS’nin en yüksek etkileri gösterdiği söylenebilir.

Anahtar Kelime: Antidiyabetik antimikrobiyal kateşik Juniperus Prunus

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YUCA H, Demircan H, AYDIN B, Önal M, TEKMAN E, CIVAS A, Nobarirezaeyeh M, Göger G, KARAKAYA S, Güvenalp Z (2023). COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES. , 650 - 666. 10.33483/jfpau.1218845
Chicago	YUCA Hafize,Demircan Hakkı Cem,AYDIN Bilge,Önal Mehmet,TEKMAN Enes,CIVAS AYSE,Nobarirezaeyeh Mohaddeseh,Göger Gamze,KARAKAYA Songül,Güvenalp Zühal COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES. (2023): 650 - 666. 10.33483/jfpau.1218845
MLA	YUCA Hafize,Demircan Hakkı Cem,AYDIN Bilge,Önal Mehmet,TEKMAN Enes,CIVAS AYSE,Nobarirezaeyeh Mohaddeseh,Göger Gamze,KARAKAYA Songül,Güvenalp Zühal COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES. , 2023, ss.650 - 666. 10.33483/jfpau.1218845
AMA	YUCA H,Demircan H,AYDIN B,Önal M,TEKMAN E,CIVAS A,Nobarirezaeyeh M,Göger G,KARAKAYA S,Güvenalp Z COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES. . 2023; 650 - 666. 10.33483/jfpau.1218845
Vancouver	YUCA H,Demircan H,AYDIN B,Önal M,TEKMAN E,CIVAS A,Nobarirezaeyeh M,Göger G,KARAKAYA S,Güvenalp Z COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES. . 2023; 650 - 666. 10.33483/jfpau.1218845
IEEE	YUCA H,Demircan H,AYDIN B,Önal M,TEKMAN E,CIVAS A,Nobarirezaeyeh M,Göger G,KARAKAYA S,Güvenalp Z "COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES." , ss.650 - 666, 2023. 10.33483/jfpau.1218845
ISNAD	YUCA, Hafize vd. "COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES". (2023), 650-666. https://doi.org/10.33483/jfpau.1218845

APA	YUCA H, Demircan H, AYDIN B, Önal M, TEKMAN E, CIVAS A, Nobarirezaeyeh M, Göger G, KARAKAYA S, Güvenalp Z (2023). COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 47(2), 650 - 666. 10.33483/jfpau.1218845
Chicago	YUCA Hafize,Demircan Hakkı Cem,AYDIN Bilge,Önal Mehmet,TEKMAN Enes,CIVAS AYSE,Nobarirezaeyeh Mohaddeseh,Göger Gamze,KARAKAYA Songül,Güvenalp Zühal COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi 47, no.2 (2023): 650 - 666. 10.33483/jfpau.1218845
MLA	YUCA Hafize,Demircan Hakkı Cem,AYDIN Bilge,Önal Mehmet,TEKMAN Enes,CIVAS AYSE,Nobarirezaeyeh Mohaddeseh,Göger Gamze,KARAKAYA Songül,Güvenalp Zühal COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi, vol.47, no.2, 2023, ss.650 - 666. 10.33483/jfpau.1218845
AMA	YUCA H,Demircan H,AYDIN B,Önal M,TEKMAN E,CIVAS A,Nobarirezaeyeh M,Göger G,KARAKAYA S,Güvenalp Z COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2023; 47(2): 650 - 666. 10.33483/jfpau.1218845
Vancouver	YUCA H,Demircan H,AYDIN B,Önal M,TEKMAN E,CIVAS A,Nobarirezaeyeh M,Göger G,KARAKAYA S,Güvenalp Z COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES. Ankara Üniversitesi Eczacılık Fakültesi Dergisi. 2023; 47(2): 650 - 666. 10.33483/jfpau.1218845
IEEE	YUCA H,Demircan H,AYDIN B,Önal M,TEKMAN E,CIVAS A,Nobarirezaeyeh M,Göger G,KARAKAYA S,Güvenalp Z "COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES." Ankara Üniversitesi Eczacılık Fakültesi Dergisi, 47, ss.650 - 666, 2023. 10.33483/jfpau.1218845
ISNAD	YUCA, Hafize vd. "COMPARISON OF SOME BIOLOGICAL ACTIVITIES AND CATECHIN TANNIN CONTENTS OF TWO JUNIPERUS AND PRUNUS SPECIES". Ankara Üniversitesi Eczacılık Fakültesi Dergisi 47/2 (2023), 650-666. https://doi.org/10.33483/jfpau.1218845