Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder

Yaman, Mesut Emre; Emmez, Hakan; ERTEK, irem; UÇAR, Önder; CANDANSAYAR, SELÇUK

doi:10.5152/pcp.2021.21223

Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder

İrem EKMEKÇİ ERTEK, (Psikiyatri Anabilim Dalı, Gazi Üniversitesi Tıp Fakültesi, Ankara, Türkiye)

Önder UÇAR, (Psikiyatri Anabilim Dalı, Gazi Üniversitesi Tıp Fakültesi, Ankara, Türkiye)

Hakan EMMEZ, (Nöroşirürji Anabilim Dalı, Gazi Üniversitesi Tıp Fakültesi, Ankara, Türkiye)

Mesut Emre YAMAN, (Nöroşirürji Anabilim Dalı, Gazi Üniversitesi Tıp Fakültesi, Ankara, Türkiye)

Selçuk CANDANSAYAR (Psikiyatri Anabilim Dalı, Gazi Üniversitesi Tıp Fakültesi, Ankara, Türkiye)

Psychiatry and clinical psychopharmacology (Online)

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Yıl: 2021 Cilt: 31 Sayı: 4 Sayfa Aralığı: 401 - 407 Metin Dili: İngilizce DOI: 10.5152/pcp.2021.21223 İndeks Tarihi: 26-05-2023

Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder

Öz:

Background: Obsessive-compulsive disorder (OCD) is a common disease that has negative effects on functionality, and 10% of the patients do not respond to first-line treatments. Gamma-knife radiosurgery (GKRS) has been used in patients with treatment-resistant OCD, but the data on long-term outcomes are still unsatisfactory. Methods: In this study, 12 patients who underwent GKRS between 2005 and 2020 were evaluated retrospectively. Anterior capsulotomy was performed using two 4-mm isocenters at the midputaminal point of the anterior limb of the internal capsule on each side with a maximum radiation dose of 140-180 Gy. Patients were followed up with the Yale-Brown Obsession and Compulsion Scale (Y-BOCS), Montgomery-Asberg Depression Rating Scale (MADRS), and Brief Psychiatric Rating Scale (BPRS) on the first, third, and sixth months. Results: After the procedure, a 35% reduction was observed in the overall Y-BOCS scores, and full response rate was 50%. There was a 49.5% decrease in the MADRS scores and a 57.8% decrease in the BPRS. Conclusion: GKRS is an effective and non-invasive procedure with favorable side effects in treatment- resistant OCD with selected patients.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ERTEK i, UÇAR Ö, Emmez H, Yaman M, CANDANSAYAR S (2021). Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder. , 401 - 407. 10.5152/pcp.2021.21223
Chicago	ERTEK irem,UÇAR Önder,Emmez Hakan,Yaman Mesut Emre,CANDANSAYAR SELÇUK Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder. (2021): 401 - 407. 10.5152/pcp.2021.21223
MLA	ERTEK irem,UÇAR Önder,Emmez Hakan,Yaman Mesut Emre,CANDANSAYAR SELÇUK Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder. , 2021, ss.401 - 407. 10.5152/pcp.2021.21223
AMA	ERTEK i,UÇAR Ö,Emmez H,Yaman M,CANDANSAYAR S Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder. . 2021; 401 - 407. 10.5152/pcp.2021.21223
Vancouver	ERTEK i,UÇAR Ö,Emmez H,Yaman M,CANDANSAYAR S Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder. . 2021; 401 - 407. 10.5152/pcp.2021.21223
IEEE	ERTEK i,UÇAR Ö,Emmez H,Yaman M,CANDANSAYAR S "Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder." , ss.401 - 407, 2021. 10.5152/pcp.2021.21223
ISNAD	ERTEK, irem vd. "Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder". (2021), 401-407. https://doi.org/10.5152/pcp.2021.21223

APA	ERTEK i, UÇAR Ö, Emmez H, Yaman M, CANDANSAYAR S (2021). Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder. Psychiatry and clinical psychopharmacology (Online), 31(4), 401 - 407. 10.5152/pcp.2021.21223
Chicago	ERTEK irem,UÇAR Önder,Emmez Hakan,Yaman Mesut Emre,CANDANSAYAR SELÇUK Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder. Psychiatry and clinical psychopharmacology (Online) 31, no.4 (2021): 401 - 407. 10.5152/pcp.2021.21223
MLA	ERTEK irem,UÇAR Önder,Emmez Hakan,Yaman Mesut Emre,CANDANSAYAR SELÇUK Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder. Psychiatry and clinical psychopharmacology (Online), vol.31, no.4, 2021, ss.401 - 407. 10.5152/pcp.2021.21223
AMA	ERTEK i,UÇAR Ö,Emmez H,Yaman M,CANDANSAYAR S Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder. Psychiatry and clinical psychopharmacology (Online). 2021; 31(4): 401 - 407. 10.5152/pcp.2021.21223
Vancouver	ERTEK i,UÇAR Ö,Emmez H,Yaman M,CANDANSAYAR S Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder. Psychiatry and clinical psychopharmacology (Online). 2021; 31(4): 401 - 407. 10.5152/pcp.2021.21223
IEEE	ERTEK i,UÇAR Ö,Emmez H,Yaman M,CANDANSAYAR S "Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder." Psychiatry and clinical psychopharmacology (Online), 31, ss.401 - 407, 2021. 10.5152/pcp.2021.21223
ISNAD	ERTEK, irem vd. "Treatment Outcomes of Gamma-Knife Radio Surgery in Refractory Obsessive-Compulsive Disorder". Psychiatry and clinical psychopharmacology (Online) 31/4 (2021), 401-407. https://doi.org/10.5152/pcp.2021.21223