Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method

Yakup GÜLTEKİN, (Farmasötik Teknoloji Anabilim Dalı, Eczacılık Fakültesi, Selçuk Üniversitesi, Konya, Türkiye)
Naile ÖZTÜRK, (İnönü Üniversitesi Eczacılık Fakültesi Farmasötik Teknoloji Anabilim Dalı, Malatya, Türkiye)
Ayhan FİLAZİ, (Veteriner Fakültesi, Farmakoloji ve Toksikoloji Anabilim Dalı, Ankara Üniversitesi, Ankara, Türkiye)
Ahmet DENİZ, (Tıbbi Parazitoloji Anabilim Dalı, Tıp Fakültesi, Kafkas Üniversitesi, Kars, Türkiye)
Cagla Korkmaz, (Parazitoloji Anabilim Dalı Veteriner Kontrol Merkez Araştırma Enstitüsü Müdürlüğü, Ankara, Türkiye)
Esra PEZİK, (Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Hacettepe Üniversitesi, Ankara, Türkiye)
Gözde BARIN, (Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Hacettepe Üniversitesi, Ankara, Türkiye)
İmran VURAL (Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Hacettepe Üniversitesi, Ankara, Türkiye.)
Journal of research in pharmacy (online)
14 0
Yıl: 2022 Cilt: 26 Sayı: 6 Sayfa Aralığı: 1608 - 1618 Metin Dili: İngilizce DOI: 10.29228/jrp.252 İndeks Tarihi: 27-05-2023

Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method

Öz:
A simple, rapid and reproducible HPLC method has been developed and validated for the quantification of albendazole sulfoxide (ALBSOX) and praziquantel (PRZ), which can coexist in various dosage forms. Chromatographic separation was performed in gradient mode using a mobile phase consisting of an InertSustain® C18 column (150 × 4.6 mm, 5 μm) and acetonitrile: water (v/v) at a flow rate of 1.0 mL/min. The active substance peaks were well separated and detected by a DAD detector at 217 nm. The HPLC method was linear for ALBSOX and PRZ in the concentration range of 0.1-50 μg/mL. Limit of detection (LOD) was found to be 0.01 μg/mL for ALBSOX and 0.009 μg/mL for PRZ. The limit of quantification (LOQ) was found to be 0.03 μg/mL for ALBSOX and 0.027 μg/mL for PRZ. The developed HPLC method was validated based on ICH guidelines for specificity, linearity, system suitability, precision and accuracy. The method was applied for simultaneous quantification and characterization studies of ALBSOX and PRA in PLGA nanoparticles.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA GÜLTEKİN Y, Ozturk N, FİLAZİ A, Deniz A, Korkmaz C, E, BARIN G, Vural I (2022). Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method. , 1608 - 1618. 10.29228/jrp.252
Chicago GÜLTEKİN Yakup,Ozturk Naile,FİLAZİ Ayhan,Deniz Ahmet,Korkmaz Cagla, Esra Pezik,BARIN GÖZDE,Vural Imran Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method. (2022): 1608 - 1618. 10.29228/jrp.252
MLA GÜLTEKİN Yakup,Ozturk Naile,FİLAZİ Ayhan,Deniz Ahmet,Korkmaz Cagla, Esra Pezik,BARIN GÖZDE,Vural Imran Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method. , 2022, ss.1608 - 1618. 10.29228/jrp.252
AMA GÜLTEKİN Y,Ozturk N,FİLAZİ A,Deniz A,Korkmaz C, E,BARIN G,Vural I Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method. . 2022; 1608 - 1618. 10.29228/jrp.252
Vancouver GÜLTEKİN Y,Ozturk N,FİLAZİ A,Deniz A,Korkmaz C, E,BARIN G,Vural I Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method. . 2022; 1608 - 1618. 10.29228/jrp.252
IEEE GÜLTEKİN Y,Ozturk N,FİLAZİ A,Deniz A,Korkmaz C, E,BARIN G,Vural I "Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method." , ss.1608 - 1618, 2022. 10.29228/jrp.252
ISNAD GÜLTEKİN, Yakup vd. "Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method". (2022), 1608-1618. https://doi.org/10.29228/jrp.252
APA GÜLTEKİN Y, Ozturk N, FİLAZİ A, Deniz A, Korkmaz C, E, BARIN G, Vural I (2022). Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method. Journal of research in pharmacy (online), 26(6), 1608 - 1618. 10.29228/jrp.252
Chicago GÜLTEKİN Yakup,Ozturk Naile,FİLAZİ Ayhan,Deniz Ahmet,Korkmaz Cagla, Esra Pezik,BARIN GÖZDE,Vural Imran Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method. Journal of research in pharmacy (online) 26, no.6 (2022): 1608 - 1618. 10.29228/jrp.252
MLA GÜLTEKİN Yakup,Ozturk Naile,FİLAZİ Ayhan,Deniz Ahmet,Korkmaz Cagla, Esra Pezik,BARIN GÖZDE,Vural Imran Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method. Journal of research in pharmacy (online), vol.26, no.6, 2022, ss.1608 - 1618. 10.29228/jrp.252
AMA GÜLTEKİN Y,Ozturk N,FİLAZİ A,Deniz A,Korkmaz C, E,BARIN G,Vural I Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method. Journal of research in pharmacy (online). 2022; 26(6): 1608 - 1618. 10.29228/jrp.252
Vancouver GÜLTEKİN Y,Ozturk N,FİLAZİ A,Deniz A,Korkmaz C, E,BARIN G,Vural I Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method. Journal of research in pharmacy (online). 2022; 26(6): 1608 - 1618. 10.29228/jrp.252
IEEE GÜLTEKİN Y,Ozturk N,FİLAZİ A,Deniz A,Korkmaz C, E,BARIN G,Vural I "Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method." Journal of research in pharmacy (online), 26, ss.1608 - 1618, 2022. 10.29228/jrp.252
ISNAD GÜLTEKİN, Yakup vd. "Simultaneous determination of albendazole sulfoxide and praziquantel from PLGA nanoparticles and validation of new HPLC method". Journal of research in pharmacy (online) 26/6 (2022), 1608-1618. https://doi.org/10.29228/jrp.252
Sayfa Oluşturulma Tarihi
24-04-2024 7:29

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