Deneysel epilepsi modelleri

BAMBAL, Gönül; ÇAKIL, Duygu; EKİCİ, Fatih

Deneysel epilepsi modelleri

Gönül BAMBAL, (Dumlupınar Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Kütahya, Türkiye)

Duygu ÇAKIL, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Tokat, Türkiye)

Fatih EKİCİ (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Tokat, Türkiye)

Journal of Clinical and Experimental Investigations

38 8

Yıl: 2011 Cilt: 2 Sayı: 1 Sayfa Aralığı: 118 - 123 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Deneysel epilepsi modelleri

Öz:

Epilepsi, % 1 prevelansa sahip olduğu tahmin edilen, dünyada en yaygın görülen ciddi nörololojik durumdur. Birçok sayıda, deneysel epilepsi ve nöbet modeli geliştirilmiştir. Bu deneysel modeller hayvanlarda elektrik uyarımı, kimyasal konvülsanlar, genetik modeller, yapısal lezyonlar, fiziksel uyaranlar (soğuk, basınç, hipertermi, elektriksel) ile oluşturulmaktadır. İyi karakterize edilmiş hayvan modelleri epileptogenezisin (normal nöronal bir ağın spontan, tekrarlayan nöbetlerin oluştuğu bir hipereksitabilite ağına değişmesi) altında yatan temel mekanizmaların anlaşılmasına olanak sağlayabilmektedir. Üstelik bu modeller epilepsi tedavisinde yeni tedavi edici yaklaşımların belirlenmesinde de yararlı olabilmektedir.

Anahtar Kelime:

Konular: Cerrahi

Models of experimental epilepsy

Öz:

Epilepsy is the most common serious neurological condition in the world, with an estimated prevalence of 1% of the population. A large number of experimental models of seizure and epilepsy have been developed. These experimental models are elicited by chemical convulsants, electrical stimulation, genetic models, structural lesions, physical stimuli (cold, pressure, hyperthermia, electrical) in animals. Well-characterized animal models may allow the understanding of the basic mechanisms underlying epileptogenesis (it refers to the alteration of a normal neuronal network into a hyperexcitable network in which recurrent, spontaneous seizures occur). Moreover, these models might also prove useful in identifying novel therapeutic approaches to treatment of epilepsy.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Seino M. Classification criteria of epileptic seizures and syndromes. Epilepsy Res 2006;70(Suppl 1):27-33.
2. Zupec-Kania BA, Spellman E. An overview of the ketogenic diet for pediatric epilepsy. Nutr Clin Pract 2009;23:589-596.
3. Bertram EH. Temporal lobe epilepsy: where do the seizures really begin? Epilepsy Behav 2009;14(Suppl 1):32-37.
4. Cloix JF, Hévor T. Epilepsy, regulation of brain energy metabolism and neurotransmission. Curr Med Chem 2009;16:841-853.
5. Lehnertz K, Bialonski S, Horstmann MT, et al. Synchronization phenomena in human epileptic brain networks. J Neurosci Methods 2009;183:42-48.
6. Artieda J, Alegre M, Valencia M, et al. Brain oscillations: pathophysiological and potentially therapeutic role in some neurological and psychiatric diseases. An Sist Sanit Navar 2009;32(Suppl 3):45-60.
7. Postnova S, Finke C, Jin W, Schneider H, Braun HA. A computational study of the interdependencies between neuronal impulse pattern, noise effects and synchronization. J Physiol Paris 2010;104:176-189.
8. Altay EE, Bilir E. Demans ve epilepsi. Demans Dizisi 1999;4:116-128.
9. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30:389–399.
10. Garcia Garcia ME, Garcia Morales I, Matías Guiu J. Experimental models in epilepsy. Neurologia 2010;25:181-8.
11. Galanopoulou AS, Moshé SL. The epileptic hypothesis: developmentally related arguments based on animal models. Epilepsia 2009;50(Suppl 7):37-42.
12. Engel JJ, Schwartzkroin PA. What Should Be Modeled? In: Pitkanen A, Schwartzkroin PA, Moshe SL, (eds): Models of Seizures and Epilepsy. San Diego, Elsevier Academic Press, 2006;1-14.
13. Contreras D. Experimental models in epilepsy. Elsevier Academic Press, USA. Revista de Neurologia 2000;30:370-376.
14. Fisher RS. Animal models of the epilepsies. Brain Res Brain Res Rev 1989;14:245-278.
15. McCandless DW, FineSmith RB. Chemically induced models of seizures. Animal Models of Neurological Disease, II Metabolic Encephalopathies and the Epilepsies. 1992: Vol 22.
16. Sarkisian MR. Overview of the current animal models for human seizure and epileptic disorders. Epilepsy Behavior 2001;2:201–216.
17. Onat F. Epilepsinin deneysel modelleri. Epilepsi. Nobel Tıp Kitabevleri 2008;4:37-43.
18. Coppola G, Arcieri S, D’Aniello A, et al. Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. Seizure 2010;19:296-299.
19. Danober L, Deransart C, Depaulis A, Vergnes M, Marescaux C. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog Neurobiol 1998;55:27-57.
20. Manning JP, Richards DA, Bowery NG. Pharmacology of absence epilepsy. Trends Pharmacol Sci 2003;24:542-549.
21. Morimoto K, Fahnestock M, Racine RJ. Kindling and status epilepticus models of epilepsy: rewiring the brain. Prog Neurobiol 2004;73:1-60.
22. Bethmann K, Fritschy JM, Brandt C, Löscher W. Antiepileptic drug resistant rats differ from drug responsive rats in GABAA receptor subunit expression in a model of temporal lobe epilepsy. Neurobiol Dis 2008;31:169-187.
23. Majores M, Eils J, Wiestler OD, Becker AJ. Molecular profiling of temporal lobe epilepsy: comparison of data from human tissue samples and animal models. Epilepsy Res 2004;60:173-178.
24. Goddard GV, McIntyre DC, Leech CK. A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 1969;25:295–330.
25. Bertram E. The relevance of kindling for human epilepsy. Epilepsia 2007;48(Suppl 2):65–74.
26. Nolte MW, Löscher W, Herden C, Freed WJ, Gernert M. Benefits and risks of intranigral transplantation of GABA-producing cells subsequent to the establishment of kindling-induced seizures. Neurobiol Dis 2008;31:342-354.
27. Kalynchuk LE, Pinel JP, Meaney MJ. Serotonin receptor binding and mRNA expression in the hippocampus of fearful amygdala-kindled rats. Neurosci Lett 2006;396:38-43.
28. Carçak N, Ferrandon A, Koning E, et al. Effect of stage 2 kindling on local cerebral blood flow rates in rats with genetic absence epilepsy. Epilepsia 2009;50:33-43.
29. Engel J, Pedley TA, Aicardi J, Dichter MA. Epilepsy: A Comprehensive Textbook. Second edition.Volume one. Lippincott Williams & Wilkins, USA 2008.
30. Karabekiroğlu K. Antenatal dönemde steroidlerin fötal beyin üzerine etkileri ve psikiyatrik sonuçları. Yeni Sempozyum 2007;45-56.
31. Racine RJ. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972;32;281–294.
32. Post RM. Do the epilepsies, pain syndromes, and affective disorders share common kindling-like mechanisms? Epilepsy Res 2002;50:203-219.
33. Pitkänen A, Schwartzkroin PA, Moshé SL, (Eds). Models of seizures and epilepsy. Elsevier Academic Press 2006:345-350.

APA	BAMBAL G, ÇAKIL D, EKİCİ F (2011). Deneysel epilepsi modelleri. , 118 - 123.
Chicago	BAMBAL Gönül,ÇAKIL Duygu,EKİCİ Fatih Deneysel epilepsi modelleri. (2011): 118 - 123.
MLA	BAMBAL Gönül,ÇAKIL Duygu,EKİCİ Fatih Deneysel epilepsi modelleri. , 2011, ss.118 - 123.
AMA	BAMBAL G,ÇAKIL D,EKİCİ F Deneysel epilepsi modelleri. . 2011; 118 - 123.
Vancouver	BAMBAL G,ÇAKIL D,EKİCİ F Deneysel epilepsi modelleri. . 2011; 118 - 123.
IEEE	BAMBAL G,ÇAKIL D,EKİCİ F "Deneysel epilepsi modelleri." , ss.118 - 123, 2011.
ISNAD	BAMBAL, Gönül vd. "Deneysel epilepsi modelleri". (2011), 118-123.

APA	BAMBAL G, ÇAKIL D, EKİCİ F (2011). Deneysel epilepsi modelleri. Journal of Clinical and Experimental Investigations, 2(1), 118 - 123.
Chicago	BAMBAL Gönül,ÇAKIL Duygu,EKİCİ Fatih Deneysel epilepsi modelleri. Journal of Clinical and Experimental Investigations 2, no.1 (2011): 118 - 123.
MLA	BAMBAL Gönül,ÇAKIL Duygu,EKİCİ Fatih Deneysel epilepsi modelleri. Journal of Clinical and Experimental Investigations, vol.2, no.1, 2011, ss.118 - 123.
AMA	BAMBAL G,ÇAKIL D,EKİCİ F Deneysel epilepsi modelleri. Journal of Clinical and Experimental Investigations. 2011; 2(1): 118 - 123.
Vancouver	BAMBAL G,ÇAKIL D,EKİCİ F Deneysel epilepsi modelleri. Journal of Clinical and Experimental Investigations. 2011; 2(1): 118 - 123.
IEEE	BAMBAL G,ÇAKIL D,EKİCİ F "Deneysel epilepsi modelleri." Journal of Clinical and Experimental Investigations, 2, ss.118 - 123, 2011.
ISNAD	BAMBAL, Gönül vd. "Deneysel epilepsi modelleri". Journal of Clinical and Experimental Investigations 2/1 (2011), 118-123.