Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis

YILDIRIM, TÜLAY; AKBULUT, EKREM; Ozturk, Onur

doi:10.1515/tjb-2022-0007

Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis

Ekrem AKBULUT, (Malatya Turgut Özal Üniversitesi, Biyomühendislik Fakültesi, Mühendislik ve Doğa Bilimleri, Malatya, Türkiye)

Tulay YILDIRIM, (İnönü Üniversitesi, Fizik Tedavi ve Rehabilitasyon, Malatya, Türkiye)

Onur ÖZTÜRK (Malatya Turgut Özal Üniversitesi, Tıp Fakültesi, Biyofizik, Malatya, Türkiye)

Türk Biyokimya Dergisi

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Yıl: 2022 Cilt: 47 Sayı: 4 Sayfa Aralığı: 465 - 473 Metin Dili: İngilizce DOI: 10.1515/tjb-2022-0007 İndeks Tarihi: 29-05-2023

Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis

Öz:

Objectives: Endoplasmic reticulum aminopeptidase-1 (ERAP1) polymorphic changes cause autoimmunity. To understand the contribution of ERAP1 to the occurrence of rheumatoid arthritis (RA) disease, we investigated the relationship between ERAP1 and RA. Methods: This study was conducted with 201 patients and 171 healthy controls. The rs26653, rs27044, rs27582, rs28096, and rs30187 polymorphic regions of ERAP1 were investi- gated. The comparison was done with Arlequin software and logistic regression. Haplotypes were analyzed with Phylogenetic Network software. ERAP1 was modeled using Promod3. Topological changes in ERAP1 were analyzed with TM-Score. Results: The results showed that rs26653G>C (p=0.002, OR=2.001, 95%CI=1.276–3.137), rs27044C>G (p=0.037, OR=1.583, 95%CI=1.028–2.440), rs27582G>A (p<0.05, OR=0.348, 95%CI=0.194–0.622) and rs30187C>T (p=0.006, OR=1.849, 95%CI=1.191–2.870) polymorphisms are asso- ciated with RA disease risk. The relationship between rs28096 polymorphism and RA disease risk could not be determined (p=0.509). The risk haplotype for rheumatoid arthritis was determined as [CGAAT]. It was determined that polymorphisms of ERAP1 cause changes in the entry pocket of substrate and ligand. Conclusions: We report a haplotype [CGAAT] that is associated with RA risk from Turkey that has not been described before. These data will make important contri- butions to elucidating the molecular mechanism of RA.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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The online version of this article offers supplementary material (https://doi.org/10.1515/tjb-2022-0007).

APA	AKBULUT E, YILDIRIM T, Ozturk O (2022). Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. , 465 - 473. 10.1515/tjb-2022-0007
Chicago	AKBULUT EKREM,YILDIRIM TÜLAY,Ozturk Onur Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. (2022): 465 - 473. 10.1515/tjb-2022-0007
MLA	AKBULUT EKREM,YILDIRIM TÜLAY,Ozturk Onur Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. , 2022, ss.465 - 473. 10.1515/tjb-2022-0007
AMA	AKBULUT E,YILDIRIM T,Ozturk O Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. . 2022; 465 - 473. 10.1515/tjb-2022-0007
Vancouver	AKBULUT E,YILDIRIM T,Ozturk O Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. . 2022; 465 - 473. 10.1515/tjb-2022-0007
IEEE	AKBULUT E,YILDIRIM T,Ozturk O "Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis." , ss.465 - 473, 2022. 10.1515/tjb-2022-0007
ISNAD	AKBULUT, EKREM vd. "Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis". (2022), 465-473. https://doi.org/10.1515/tjb-2022-0007

APA	AKBULUT E, YILDIRIM T, Ozturk O (2022). Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. Türk Biyokimya Dergisi, 47(4), 465 - 473. 10.1515/tjb-2022-0007
Chicago	AKBULUT EKREM,YILDIRIM TÜLAY,Ozturk Onur Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. Türk Biyokimya Dergisi 47, no.4 (2022): 465 - 473. 10.1515/tjb-2022-0007
MLA	AKBULUT EKREM,YILDIRIM TÜLAY,Ozturk Onur Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. Türk Biyokimya Dergisi, vol.47, no.4, 2022, ss.465 - 473. 10.1515/tjb-2022-0007
AMA	AKBULUT E,YILDIRIM T,Ozturk O Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. Türk Biyokimya Dergisi. 2022; 47(4): 465 - 473. 10.1515/tjb-2022-0007
Vancouver	AKBULUT E,YILDIRIM T,Ozturk O Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis. Türk Biyokimya Dergisi. 2022; 47(4): 465 - 473. 10.1515/tjb-2022-0007
IEEE	AKBULUT E,YILDIRIM T,Ozturk O "Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis." Türk Biyokimya Dergisi, 47, ss.465 - 473, 2022. 10.1515/tjb-2022-0007
ISNAD	AKBULUT, EKREM vd. "Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis". Türk Biyokimya Dergisi 47/4 (2022), 465-473. https://doi.org/10.1515/tjb-2022-0007