TY  - JOUR
TI  - Endoplasmic reticulum aminopeptidase-1 polymorphism increases the risk of rheumatoid arthritis
AB  - Objectives: Endoplasmic reticulum aminopeptidase-1 (ERAP1) polymorphic changes cause autoimmunity. To understand the contribution of ERAP1 to the occurrence of rheumatoid arthritis (RA) disease, we investigated the relationship between ERAP1 and RA. Methods: This study was conducted with 201 patients and 171 healthy controls. The rs26653, rs27044, rs27582, rs28096, and rs30187 polymorphic regions of ERAP1 were investi- gated. The comparison was done with Arlequin software and logistic regression. Haplotypes were analyzed with Phylogenetic Network software. ERAP1 was modeled using Promod3. Topological changes in ERAP1 were analyzed with TM-Score. Results: The results showed that rs26653G>C (p=0.002, OR=2.001, 95%CI=1.276–3.137), rs27044C>G (p=0.037, OR=1.583, 95%CI=1.028–2.440), rs27582G>A (p<0.05, OR=0.348, 95%CI=0.194–0.622) and rs30187C>T (p=0.006, OR=1.849, 95%CI=1.191–2.870) polymorphisms are asso- ciated with RA disease risk. The relationship between rs28096 polymorphism and RA disease risk could not be determined (p=0.509). The risk haplotype for rheumatoid arthritis was determined as [CGAAT]. It was determined that polymorphisms of ERAP1 cause changes in the entry pocket of substrate and ligand. Conclusions: We report a haplotype [CGAAT] that is associated with RA risk from Turkey that has not been described before. These data will make important contri- butions to elucidating the molecular mechanism of RA.
AU  - YILDIRIM, TÜLAY
AU  - AKBULUT, EKREM
AU  - Ozturk, Onur
DO  - 10.1515/tjb-2022-0007
PY  - 2022
JO  - Türk Biyokimya Dergisi
VL  - 47
IS  - 4
SN  - 1303-829X
SP  - 465
EP  - 473
DB  - TRDizin
UR  - http://search/yayin/detay/1176439
ER  -