TY  - JOUR
TI  - Can omalizumab be an alternative treatment for non-atopic severe asthma? A real-life experience with omalizumab
AB  - Introduction: Omalizumab, a humanized monoclonal anti-IgE antibody, has largely demonstrated its efficacy in severe allergic asthma. There are limited data about the effectiveness of omalizumab in patients with non-atopic severe persistent asthma. In this study, we aimed to determine the effect of omalizu- mab in patients with non-atopic severe asthma and compare the data obtai- ned with those in patients with allergic severe asthma. Materials and Methods: This study was an observational, retrospective, terti- ary single-center study that assessed and compared the clinical outcome of adult patients with severe asthma (165 atopic and 41 non-atopic) who have been on omalizumab for one year or longer between January 2008 and January 2020. Effectiveness was assessed by considering symptom scores (GINA symptom control score), daily systemic corticosteroids (SCS) dosage, blood eosinophil counts, pulmonary function, and number of severe exacer- bations and hospitalizations within the last one year. Results: Omalizumab exhibited significant improvement in the clinical status of non-atopic asthma patients as measured by GINA symptom score [decrea- sed from 3.77 ± 0.63 to 1.36 ± 1.27 (p< 0.001)], the number of emergency room visits for asthma [decreased from 11.25 ± 14.69 to 0.25 ± 0.55 (p< 0.001)], and the number of hospitalizations [decreased from 1.17 ± 2.87 to 0.14 ± 0.36 (p= 0.036)]. These results were not significantly different from those obtained in allergic asthma patients. FEV1 improved significantly from 2.08 ± 0.86 to 2.14 ± 0.84 (p= 0.041) and oral corticosteroid doses decrea- sed significantly from 1.67 ± 7.49 to 0.46 ± 2.74 (p= 0.015) in the only atopic group. Conclusion: Omalizumab, which is a proven and effective treatment option for allergic asthma, may also be an efficacious alternative option in non-atopic severe asthma.
AU  - Ediger, Dane
AU  - Günaydın, Fatma Esra
AU  - Erbay, Müge
AU  - Pekbak, Gülseren
DO  - 10.5578/tt.20239904
PY  - 2023
JO  - Tüberküloz ve Toraks
VL  - 71
IS  - 1
SN  - 0494-1373
SP  - 24
EP  - 33
DB  - TRDizin
UR  - http://search/yayin/detay/1176784
ER  -