The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis
Yıl: 2023 Cilt: 47 Sayı: 1 Sayfa Aralığı: 38 - 41 Metin Dili: İngilizce DOI: 10.4274/tpd.galenos.2022.07088 İndeks Tarihi: 30-05-2023
The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis
Öz: Objective: The aim of this study was to determine the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), and malondialdehyde (MDA) in the patients infected with Fasciola hepatica and establish whether these parameters differ among the patients with fascioliasis. Methods: The patient group consisted of 140 individuals with F. hepatica seropositive; the control group consisted of 140 healthy individuals who tested negative for this parasite and had no other diseases. The patient group consisted of individuals with no chronic diseases other than fascioliasis; in both the patient and the control groups, the subjects had no unhealthy habits such as smoking and alcohol consumption, etc. The blood samples taken to diagnose fascioliasis were evaluated by the ELISA method. The samples were studied according to the kit procedures for SOD, CAT, GPx and MDA markers. Results: In this study, 43.6% of 140 individuals in the patient group infected with F. hepatica had CAT (p=0.001), 35% had GPx (p=0.001), 12.9% had SOD (p=0.002), 90.7% had MDA (p=0.001). There was found a statistically significant difference between the patient and the control group in terms of the positivity of these four parameters. Conclusion: As a result, a statistically significant relationship was found between the increase in the SOD, GPx, CAT, and MDA levels and fascioliasis. The high rate of MDA revealed that oxidative stress occurred in patients with fascioliasis, resulting in an increased activity of SOD, GPx, and CAT.
Anahtar Kelime: İnsan Fascioliasisinde Antioksidan Enzimler ve Oksidatif Stresin Önemi
Öz: Amaç: Bu çalışmanın amacı, Fasciola hepatica ile enfekte hastalarda süperoksit dismutaz (SOD), glutatyon peroksidaz (GPx), katalaz (CAT) ve malondialdehit (MDA) düzeylerini belirlemek ve fascioliasisli hastalarda bu parametrelerde farklılık meydana gelip gelmediğini ortaya koymaktır. Yöntemler: Hasta grubu, F. hepatica pozitif olan 140 hastadan; kontrol grubu ise bu parazit yönünden negatif bulunan ve başka herhangi bir hastalığı bulunmayan 140 sağlıklı kişiden oluşturuldu. Hasta grubuna fascioliasis dışında herhangi bir kronik hastalığı olmayan ve hem hasta hem de kontrol grubuna sigara, alkol kullanımı olmayan kişiler dahil edildi. Hastalarda fascioliasis pozitifliğini belirlemek için alınan kan örnekleri ELISA yöntemi ile çalışıldı. Serum SOD, CAT, GPx ve MDA düzeyleri ELISA yöntemi ile değerlendirildi. Bulgular: Bu çalışmada F. hepatica ile enfekte hasta grubundaki 140 kişinin %43,6’sında CAT (p=0,001), %35’inde GPx (p=0,001), %12,9’unda SOD (p=0,002) ve %90,7 MDA pozitifliği saptandı. Bu dört parametrenin pozitifliği açısından hasta ve kontrol grubu arasında istatistiksel olarak anlamlı fark bulundu (p=0,001). Sonuç: Sonuç olarak SOD, GPx, CAT ve MDA düzeyindeki artış ile fascioliasis arasında istatistik olarak anlamlı bir ilişki saptanmıştır. Çalışmamızda MDA’nın yüksek oranda saptanmış olması fascioliasisli hastalarda oksidatif stres oluştuğunu ve SOD, GPx ve CAT aktivitelerinde artış olduğunu ortaya koymuştur.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Tas Cengiz Z, YILMAZ H, Beyhan Y, Ekici A, ÇİÇEK M, AYDEMIR S (2023). The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis. , 38 - 41. 10.4274/tpd.galenos.2022.07088 |
| Chicago | Tas Cengiz Zeynep,YILMAZ Hasan,Beyhan Yunus Emre,Ekici Abdurrahman,ÇİÇEK Mutalip,AYDEMIR SELAHATTIN The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis. (2023): 38 - 41. 10.4274/tpd.galenos.2022.07088 |
| MLA | Tas Cengiz Zeynep,YILMAZ Hasan,Beyhan Yunus Emre,Ekici Abdurrahman,ÇİÇEK Mutalip,AYDEMIR SELAHATTIN The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis. , 2023, ss.38 - 41. 10.4274/tpd.galenos.2022.07088 |
| AMA | Tas Cengiz Z,YILMAZ H,Beyhan Y,Ekici A,ÇİÇEK M,AYDEMIR S The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis. . 2023; 38 - 41. 10.4274/tpd.galenos.2022.07088 |
| Vancouver | Tas Cengiz Z,YILMAZ H,Beyhan Y,Ekici A,ÇİÇEK M,AYDEMIR S The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis. . 2023; 38 - 41. 10.4274/tpd.galenos.2022.07088 |
| IEEE | Tas Cengiz Z,YILMAZ H,Beyhan Y,Ekici A,ÇİÇEK M,AYDEMIR S "The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis." , ss.38 - 41, 2023. 10.4274/tpd.galenos.2022.07088 |
| ISNAD | Tas Cengiz, Zeynep vd. "The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis". (2023), 38-41. https://doi.org/10.4274/tpd.galenos.2022.07088 |
| APA | Tas Cengiz Z, YILMAZ H, Beyhan Y, Ekici A, ÇİÇEK M, AYDEMIR S (2023). The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis. Türkiye Parazitoloji Dergisi, 47(1), 38 - 41. 10.4274/tpd.galenos.2022.07088 |
| Chicago | Tas Cengiz Zeynep,YILMAZ Hasan,Beyhan Yunus Emre,Ekici Abdurrahman,ÇİÇEK Mutalip,AYDEMIR SELAHATTIN The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis. Türkiye Parazitoloji Dergisi 47, no.1 (2023): 38 - 41. 10.4274/tpd.galenos.2022.07088 |
| MLA | Tas Cengiz Zeynep,YILMAZ Hasan,Beyhan Yunus Emre,Ekici Abdurrahman,ÇİÇEK Mutalip,AYDEMIR SELAHATTIN The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis. Türkiye Parazitoloji Dergisi, vol.47, no.1, 2023, ss.38 - 41. 10.4274/tpd.galenos.2022.07088 |
| AMA | Tas Cengiz Z,YILMAZ H,Beyhan Y,Ekici A,ÇİÇEK M,AYDEMIR S The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis. Türkiye Parazitoloji Dergisi. 2023; 47(1): 38 - 41. 10.4274/tpd.galenos.2022.07088 |
| Vancouver | Tas Cengiz Z,YILMAZ H,Beyhan Y,Ekici A,ÇİÇEK M,AYDEMIR S The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis. Türkiye Parazitoloji Dergisi. 2023; 47(1): 38 - 41. 10.4274/tpd.galenos.2022.07088 |
| IEEE | Tas Cengiz Z,YILMAZ H,Beyhan Y,Ekici A,ÇİÇEK M,AYDEMIR S "The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis." Türkiye Parazitoloji Dergisi, 47, ss.38 - 41, 2023. 10.4274/tpd.galenos.2022.07088 |
| ISNAD | Tas Cengiz, Zeynep vd. "The Importance of Antioxidant Enzymes and Oxidative Stress in Human Fascioliasis". Türkiye Parazitoloji Dergisi 47/1 (2023), 38-41. https://doi.org/10.4274/tpd.galenos.2022.07088 |
