Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and  22RV1 Cancer Cell Lines

Aydemir, Esra; KILIT, A. CANSU

doi:10.14744/hnhj.2021.46034

Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines

A. CANSU KILIT, (Akdeniz Üniversitesi, Moleküler Biyoloji Bölümü, Antalya, Türkiye)

Esra AYDEMİR (Akdeniz Üniversitesi, Moleküler Biyoloji Bölümü, Antalya, Türkiye)

Haydarpaşa Numune Medical Journal

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Yıl: 2023 Cilt: 63 Sayı: 2 Sayfa Aralığı: 115 - 119 Metin Dili: İngilizce DOI: 10.14744/hnhj.2021.46034 İndeks Tarihi: 30-05-2023

Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines

Öz:

Introduction: Cancer is an important public health problem worldwide and a disease that results in the highest number of deaths. Due to the existing drugs for cancer treatment, cumulative mutations, and drug interactions, treatment may fall insufficient. Hence, despite many new therapeutic approaches, there is still a need for more research to discover new molecules for treatment or for increasing drug efficacy. Regarding the development of new anticancer drugs, plant-derived agents stand out for their correlation with cancer. Flavonoids in our daily diet, together with other components like various vitamins, play a key role in the prevention of cancer. Methods: The pure punicalagin flavonoid obtained from the pomegranate peel was studied in vitro on cancer cell lines such as U87, PANC-1, A549, 22RV1 and its cytotoxic effect was tested. Results: It was observed that punicalagin showed cytotoxicity in all of the above-mentioned cancer cells, but was not cyto toxic in 293T human kidney epithelial cells. Discussion and Conclusion: We hope that this study, which shows that Punicalagin has a selective cytotoxic effect, will shed light on other studies to investigate the detailed death mechanism of Punicalagin flavonoid and to be an alternative treatment to cancer treatments.

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APA	KILIT A, Aydemir E (2023). Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines. , 115 - 119. 10.14744/hnhj.2021.46034
Chicago	KILIT A. CANSU,Aydemir Esra Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines. (2023): 115 - 119. 10.14744/hnhj.2021.46034
MLA	KILIT A. CANSU,Aydemir Esra Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines. , 2023, ss.115 - 119. 10.14744/hnhj.2021.46034
AMA	KILIT A,Aydemir E Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines. . 2023; 115 - 119. 10.14744/hnhj.2021.46034
Vancouver	KILIT A,Aydemir E Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines. . 2023; 115 - 119. 10.14744/hnhj.2021.46034
IEEE	KILIT A,Aydemir E "Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines." , ss.115 - 119, 2023. 10.14744/hnhj.2021.46034
ISNAD	KILIT, A. CANSU - Aydemir, Esra. "Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines". (2023), 115-119. https://doi.org/10.14744/hnhj.2021.46034

APA	KILIT A, Aydemir E (2023). Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines. Haydarpaşa Numune Medical Journal, 63(2), 115 - 119. 10.14744/hnhj.2021.46034
Chicago	KILIT A. CANSU,Aydemir Esra Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines. Haydarpaşa Numune Medical Journal 63, no.2 (2023): 115 - 119. 10.14744/hnhj.2021.46034
MLA	KILIT A. CANSU,Aydemir Esra Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines. Haydarpaşa Numune Medical Journal, vol.63, no.2, 2023, ss.115 - 119. 10.14744/hnhj.2021.46034
AMA	KILIT A,Aydemir E Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines. Haydarpaşa Numune Medical Journal. 2023; 63(2): 115 - 119. 10.14744/hnhj.2021.46034
Vancouver	KILIT A,Aydemir E Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines. Haydarpaşa Numune Medical Journal. 2023; 63(2): 115 - 119. 10.14744/hnhj.2021.46034
IEEE	KILIT A,Aydemir E "Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines." Haydarpaşa Numune Medical Journal, 63, ss.115 - 119, 2023. 10.14744/hnhj.2021.46034
ISNAD	KILIT, A. CANSU - Aydemir, Esra. "Cytotoxic Effects of Punicalagin on U87, PANC-1, A549, and 22RV1 Cancer Cell Lines". Haydarpaşa Numune Medical Journal 63/2 (2023), 115-119. https://doi.org/10.14744/hnhj.2021.46034