Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population

kocabeyoglu, sibel; Ağın, Abdullah; Irkec, Murat; Karakaya, Jale

doi:10.32552/2022.ActaMedica.799

Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population

Abdullah AĞIN, (Sağlık Bilimleri Üniversitesi Haseki Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Bölümü, İstanbul, Türkiye.)

Murat IRKEC, (Hacettepe Üniversitesi Tıp Fakültesi Anabilim Dalı Oftalmoloji, Ankara, Türkiye.)

Sibel KOCABEYOĞLU, (Hacettepe Üniversitesi Tıp Fakültesi Anabilim Dalı Oftalmoloji, Ankara, Türkiye.)

Jale KARAKAYA (Hacettepe Üniversitesi Tıp Fakültesi Anabilim Dalı Biyoistatistik Bölümü, Ankara, Türkiye.)

Acta Medica

9 4

Yıl: 2023 Cilt: 54 Sayı: 1 Sayfa Aralığı: 13 - 21 Metin Dili: İngilizce DOI: 10.32552/2022.ActaMedica.799 İndeks Tarihi: 30-05-2023

Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population

Öz:

Objective: To evaluate the effects of risk factors on progression in primary open-angle glaucoma (POAG) and exfoliation glaucoma (XFG). Materials and methods: The study included 139 patients with POAG and XFG followed up at Hacettepe University Faculty of Medicine, Department of Ophthalmology, Glaucoma Unit. A number of factors were evaluated through a cross-sectional design for all the patients, including age, sex, hypertension, diabetes, thyroid disease, cardiovascular disease, migraine, alcohol, smoking, family history, affected side, lens status, central corneal thickness (CCT), number of medications, body mass index (BMI), cup-to-disc (C/D) ratio, intraocular pressure (IOP), computerized automated visual field mean deviation (MD), and prior surgery. Results: The patients were divided into two groups, POAG and XFG, and further divided into the following two subgroups: progressive and nonprogressive. Of the patients, 75 (53.9%) had POAG, and 64 (46.1%) had XFG. In the patients followed up, annual MD change was 0.96 ± 1.5 dB/ year, baseline MD was −5.06 ± 5.61 dB, and IOP was 15.94 ± 1.93 mmHg. Potential risk factors for progression in the whole group were evaluated, but no significant difference was found between the groups with and without progression for all factors. Subgroup analysis revealed that in the POAG group, BMI was significantly higher in the non-progressive disease subgroup (p=0.01); furthermore, in the XFG group, IOP was significantly higher in the progressive disease subgroup (p=0.02). According to multiple logistic regression analysis, a 1-unit decrease in BMI in the POAG group increased the risk by 1.3 times (p=0.01), and smoking in the XFG group resulted in a 6-fold reduction in the risk of progression (p=0.04). Conclusion: Although mean IOP was higher in XFG group, the present study found BMI in POAG and smoking in XFG as independent factors that reduced progression in our series.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ağın A, Irkec M, kocabeyoglu s, Karakaya J (2023). Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population. , 13 - 21. 10.32552/2022.ActaMedica.799
Chicago	Ağın Abdullah,Irkec Murat,kocabeyoglu sibel,Karakaya Jale Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population. (2023): 13 - 21. 10.32552/2022.ActaMedica.799
MLA	Ağın Abdullah,Irkec Murat,kocabeyoglu sibel,Karakaya Jale Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population. , 2023, ss.13 - 21. 10.32552/2022.ActaMedica.799
AMA	Ağın A,Irkec M,kocabeyoglu s,Karakaya J Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population. . 2023; 13 - 21. 10.32552/2022.ActaMedica.799
Vancouver	Ağın A,Irkec M,kocabeyoglu s,Karakaya J Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population. . 2023; 13 - 21. 10.32552/2022.ActaMedica.799
IEEE	Ağın A,Irkec M,kocabeyoglu s,Karakaya J "Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population." , ss.13 - 21, 2023. 10.32552/2022.ActaMedica.799
ISNAD	Ağın, Abdullah vd. "Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population". (2023), 13-21. https://doi.org/10.32552/2022.ActaMedica.799

APA	Ağın A, Irkec M, kocabeyoglu s, Karakaya J (2023). Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population. Acta Medica, 54(1), 13 - 21. 10.32552/2022.ActaMedica.799
Chicago	Ağın Abdullah,Irkec Murat,kocabeyoglu sibel,Karakaya Jale Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population. Acta Medica 54, no.1 (2023): 13 - 21. 10.32552/2022.ActaMedica.799
MLA	Ağın Abdullah,Irkec Murat,kocabeyoglu sibel,Karakaya Jale Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population. Acta Medica, vol.54, no.1, 2023, ss.13 - 21. 10.32552/2022.ActaMedica.799
AMA	Ağın A,Irkec M,kocabeyoglu s,Karakaya J Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population. Acta Medica. 2023; 54(1): 13 - 21. 10.32552/2022.ActaMedica.799
Vancouver	Ağın A,Irkec M,kocabeyoglu s,Karakaya J Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population. Acta Medica. 2023; 54(1): 13 - 21. 10.32552/2022.ActaMedica.799
IEEE	Ağın A,Irkec M,kocabeyoglu s,Karakaya J "Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population." Acta Medica, 54, ss.13 - 21, 2023. 10.32552/2022.ActaMedica.799
ISNAD	Ağın, Abdullah vd. "Evaluation of Risk Factors Affecting Progression in Primary Open- Angle Glaucoma and Exfoliation Glaucoma in a Turkish Population". Acta Medica 54/1 (2023), 13-21. https://doi.org/10.32552/2022.ActaMedica.799