Silica nanoparticle synthesis by experimental design for drug and gene delivery applications

Şahin, Adem; Capan, Yilmaz; Ultav, Gozde; Tonbul, Hayrettin

doi:10.29228/jrp.243

Silica nanoparticle synthesis by experimental design for drug and gene delivery applications

Gozde Ultav, (Hacettepe Üniversitesi, Fen Bilimleri Enstitüsü, Nanoteknoloji ve Nanotıp Anabilim Dalı, Ankara, Türkiye)

Hayrettin TONBUL, (İnönü Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Malatya, Türkiye)

Adem ŞAHİN, (Bilecik Şeyh Edebali Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Eczacılık Hizmetleri Anabilim Dalı, Bilecik, Türkiye)

Yıldız ÇAPAN (Hacettepe Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, Ankara, Türkiye)

Journal of research in pharmacy (online)

8 0

Yıl: 2023 Cilt: 27 Sayı: 1 Sayfa Aralığı: 12 - 22 Metin Dili: İngilizce DOI: 10.29228/jrp.243 İndeks Tarihi: 30-05-2023

Silica nanoparticle synthesis by experimental design for drug and gene delivery applications

Öz:

Silica nanoparticles (SNPs) are one of the most researched drug/gene delivery platforms due to their easy and cheap production. Their toxicity depends on the nanoparticle characteristics like particle size or shape. It is well known that the smaller nanoparticles have a better cellular uptake potential. For this reason, in this study, we synthesized SNPs with a particle size of around 100 nm via an experimental design method that combines Technique for Order Preference by Similarity to the Ideal Solution (TOPSIS) with Taguchi design to optimize more than one response. After the optimization, average particle size, particle size distribution, zeta potential, and particle morphology of validated SNPs were analyzed. The cytotoxicity studies were performed on fibroblast cells (L929) for 48 and 72 hours. Results show that obtained nanoparticles were spherical-shaped with a size of around 100 nm and had good biocompatibility.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Ultav G, Tonbul H, Şahin A, Capan Y (2023). Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. , 12 - 22. 10.29228/jrp.243
Chicago	Ultav Gozde,Tonbul Hayrettin,Şahin Adem,Capan Yilmaz Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. (2023): 12 - 22. 10.29228/jrp.243
MLA	Ultav Gozde,Tonbul Hayrettin,Şahin Adem,Capan Yilmaz Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. , 2023, ss.12 - 22. 10.29228/jrp.243
AMA	Ultav G,Tonbul H,Şahin A,Capan Y Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. . 2023; 12 - 22. 10.29228/jrp.243
Vancouver	Ultav G,Tonbul H,Şahin A,Capan Y Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. . 2023; 12 - 22. 10.29228/jrp.243
IEEE	Ultav G,Tonbul H,Şahin A,Capan Y "Silica nanoparticle synthesis by experimental design for drug and gene delivery applications." , ss.12 - 22, 2023. 10.29228/jrp.243
ISNAD	Ultav, Gozde vd. "Silica nanoparticle synthesis by experimental design for drug and gene delivery applications". (2023), 12-22. https://doi.org/10.29228/jrp.243

APA	Ultav G, Tonbul H, Şahin A, Capan Y (2023). Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. Journal of research in pharmacy (online), 27(1), 12 - 22. 10.29228/jrp.243
Chicago	Ultav Gozde,Tonbul Hayrettin,Şahin Adem,Capan Yilmaz Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. Journal of research in pharmacy (online) 27, no.1 (2023): 12 - 22. 10.29228/jrp.243
MLA	Ultav Gozde,Tonbul Hayrettin,Şahin Adem,Capan Yilmaz Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. Journal of research in pharmacy (online), vol.27, no.1, 2023, ss.12 - 22. 10.29228/jrp.243
AMA	Ultav G,Tonbul H,Şahin A,Capan Y Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. Journal of research in pharmacy (online). 2023; 27(1): 12 - 22. 10.29228/jrp.243
Vancouver	Ultav G,Tonbul H,Şahin A,Capan Y Silica nanoparticle synthesis by experimental design for drug and gene delivery applications. Journal of research in pharmacy (online). 2023; 27(1): 12 - 22. 10.29228/jrp.243
IEEE	Ultav G,Tonbul H,Şahin A,Capan Y "Silica nanoparticle synthesis by experimental design for drug and gene delivery applications." Journal of research in pharmacy (online), 27, ss.12 - 22, 2023. 10.29228/jrp.243
ISNAD	Ultav, Gozde vd. "Silica nanoparticle synthesis by experimental design for drug and gene delivery applications". Journal of research in pharmacy (online) 27/1 (2023), 12-22. https://doi.org/10.29228/jrp.243