Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease

KERİMOĞLU, Oya; ÖZEN, Merve İrem

doi:10.29228/jrp.369

Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease

Merve İrem ÖZEN, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, İstanbul, Türkiye)

Oya KERİMOĞLU (Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Teknoloji Anabilim Dalı, İstanbul, Türkiye)

Journal of research in pharmacy (online)

6 0

Yıl: 2023 Cilt: 27 Sayı: 2 Sayfa Aralığı: 893 - 902 Metin Dili: İngilizce DOI: 10.29228/jrp.369 İndeks Tarihi: 31-05-2023

Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease

Öz:

Nowadays, innovative and more effective drug dosage forms continue to be researched and developed compared to traditional drug dosage forms. The importance of orally disintegrating films (ODFs) in current studies and advancements cannot be overstated. This study aims to create the optimum ODF formulations using pullulan and lycoat with donepezil hydrochloride (donepezil HCl). Plasticizers such as polyethylene glycol 400 (PEG-400) and glycerine were used to form flexible films. In the characterization studies of the films produced by the solvent casting technique: determination of morphology, determination of folding, determination of disintegration time, determination of thickness, determination of swelling, determination of pH, determination of mass uniformity, determination of In vitro release, and determination of content uniformity studies were carried out. According to the results obtained, the non- brittle, smooth-surfaced films were disintegrated in the mouth in an average of 35 seconds. Since the 10th minute, more than 85% of the active pharmaceutical ingredient (API) has been revealed. These values suggested that the pullulan polymer showed better film-forming capacity when used with lycoat polymer. Ultraviolet (UV)-visible spectrum studies were carried out to validate donepezil HCl. Thanks to the ODFs containing donepezil HCl, an effective and safe, innovative clinical use has been achieved in the treatment of diseases such as dementia and Alzheimer, which are characterized by a decrease in daily life activities and atrophy in cognitive abilities.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZEN M, KERİMOĞLU O (2023). Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. , 893 - 902. 10.29228/jrp.369
Chicago	ÖZEN Merve İrem,KERİMOĞLU Oya Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. (2023): 893 - 902. 10.29228/jrp.369
MLA	ÖZEN Merve İrem,KERİMOĞLU Oya Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. , 2023, ss.893 - 902. 10.29228/jrp.369
AMA	ÖZEN M,KERİMOĞLU O Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. . 2023; 893 - 902. 10.29228/jrp.369
Vancouver	ÖZEN M,KERİMOĞLU O Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. . 2023; 893 - 902. 10.29228/jrp.369
IEEE	ÖZEN M,KERİMOĞLU O "Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease." , ss.893 - 902, 2023. 10.29228/jrp.369
ISNAD	ÖZEN, Merve İrem - KERİMOĞLU, Oya. "Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease". (2023), 893-902. https://doi.org/10.29228/jrp.369

APA	ÖZEN M, KERİMOĞLU O (2023). Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. Journal of research in pharmacy (online), 27(2), 893 - 902. 10.29228/jrp.369
Chicago	ÖZEN Merve İrem,KERİMOĞLU Oya Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. Journal of research in pharmacy (online) 27, no.2 (2023): 893 - 902. 10.29228/jrp.369
MLA	ÖZEN Merve İrem,KERİMOĞLU Oya Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. Journal of research in pharmacy (online), vol.27, no.2, 2023, ss.893 - 902. 10.29228/jrp.369
AMA	ÖZEN M,KERİMOĞLU O Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. Journal of research in pharmacy (online). 2023; 27(2): 893 - 902. 10.29228/jrp.369
Vancouver	ÖZEN M,KERİMOĞLU O Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease. Journal of research in pharmacy (online). 2023; 27(2): 893 - 902. 10.29228/jrp.369
IEEE	ÖZEN M,KERİMOĞLU O "Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease." Journal of research in pharmacy (online), 27, ss.893 - 902, 2023. 10.29228/jrp.369
ISNAD	ÖZEN, Merve İrem - KERİMOĞLU, Oya. "Evaluation and characterization of orally disintegrating films loaded donepezil hydrochloride for Alzheimer’s disease". Journal of research in pharmacy (online) 27/2 (2023), 893-902. https://doi.org/10.29228/jrp.369