Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?

Gurcu, Sinem; Gönüllü, Emel; Yorulmaz, Goknur; Ekim, Ayşe; hamarat, hatice; Musmul, Ahmet

doi:10.4274/tod.galenos.2021.90582

Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?

Hatice HAMARAT, (Eskişehir Şehir Hastanesi, Dahiliye Kliniği, Eskişehir, Türkiye)

Goknur YORULMAZ, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, Endokrinoloji ve Metabolizma Anabilim Dalı, Eskişehir, Türkiye)

Ayse EKİM, (Eskişehir Şehir Hastanesi, Fizik Tedavi ve Rehabilitasyon Kliniği, Eskişehir, Türkiye)

Emel GÖNÜLLÜ, (Sakarya Üniversitesi, Tıp Fakültesi, Romatoloji Anabilim Dalı, Sakarya, Türkiye)

Ahmet MUSMUL, (Eskişehir Osmangazi Üniversitesi, Tıp Fakültesi, İstatistik Anabilim Dalı, Eskişehir, Türkiye)

Sinem Gurcu (Eskişehir Şehir Hastanesi, Eczane Kliniği, Eskişehir, Türkiye)

Türk Osteoporoz Dergisi

4 0

Yıl: 2022 Cilt: 28 Sayı: 1 Sayfa Aralığı: 26 - 31 Metin Dili: İngilizce DOI: 10.4274/tod.galenos.2021.90582 İndeks Tarihi: 31-05-2023

Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?

Öz:

Objective: Iron deficiency anemia (IDA) is common in reproductive women. 25-hydroxyvitamin D [25-(OH)D] deficiency is common in those with IDA. The study evaluated the effect of low ferritin on 25-(OH)D levels and bone mineral density (BMD). Materials and Methods: One hundred forty women (15-25 years, 25-35 years, 35-45 years, 3 groups) with ferritin level <15 ng/mL and a control group of 50 healthy women were included in the study. A vitamin D level of 25-(OH)D>30.0 ng/mL was sufficient, vitamin D deficiency was defined as 25-(OH)D≥20.0, <30.0 ng/mL. Vitamin D deficiency as 25-(OH)D<20 ng/mL. Severe vitamin D deficiency 25-(OH)D<10 ng/ mL. Femoral neck and lumbar spine BMD were measured by dual-energy X-ray absorptiometry. For the diagnosis of BMD, a Z-score of <-2 was evaluated with “lower bone mineral density than expected” and “expected bone density for >-2 years of age.” Results: The mean ages of the patients and healthy controls were 34±10 and 29±9 years. Serum 25-(OH)D level was found to be low in the patient group (p<0.01). Low-intensity BMD was present in the low ferritin groups (p>0.05). Conclusion: Low vitamin D levels detected in reproductive women with anemia cause low BMD.

Anahtar Kelime:

Düşük Ferritin Düzeyine Sahip Reprodüktif Kadınlarda D Vitamini Düzeyleri Kemik Mineral Dansitesini Etkiler mi?

Öz:

Amaç: Reprodüktif kadınlarda demir eksikliği anemisi (DEA) sık gözlenir. 25-hidroksivitamin D [25-(OH)D] eksikliği DEA olanlarda yaygındır. Ferritin düşüklüğüne bağlı oluşan 25-(OH)D eksikliğinin kemik mineral yoğunluğu (KMY) üzerindeki etkisi tartışmalıdır. Bu çalışma, reprodüktif kadınlarda serum ferritin düşüklüğünün 25-(OH)D seviyelerine etkisi ve KMY arasındaki ilişkiyi değerlendirmek için yapıldı. Gereç ve Yöntem: Çalışmaya ferritin seviyeleri <15 ng/mL olan 140 üreme dönemindeki kadın (15-25 yaş, 25-35 yaş, 35-45 yaş olmak üzere 3 grup) ve 50 sağlıklı kadından oluşan bir kontrol grubu dahil edildi. Vitamin D düzeyi 25-(OH)D>30,0 ng/mL ise yeterli, 25-(OH)D≥20,0, <30,0 ng/mL ise D vitamini yetersizliği, 25-(OH)D <20 ng/mL ise D vitamini eksikliği ve <10 ng/mL ise şiddetli D vitamini eksikliği olarak tanımlandı. Femur boynu ve lomber omurga KMY’si çift enerjili X-ışını absorpsiyometrisi ile ölçüldü. KMY tanısı için Z-skoru kullanıldı. Z-skoru <-2 ise “beklenenden daha düşük KMY’ye sahip” ve >-2 ise “yaş için beklenen kemik yoğunluğu” olarak değerlendirildi. Bulgular: Hastaların ve sağlıklı kontrollerin ortalama yaşı 34±10 ve 29±9 yıldı. Serum 25-(OH)D düzeyi hasta grubunda anlamlı farklılık oluşturacak kadar düşüktü (p<0,01). Düşük ferritin gruplarında, düşük yoğunluklu KMY vardı (p>0,05). Sonuç: Anemisi olan reprodüktif kadınlarda saptanan düşük D vitamini seviyeleri düşük KMY’ye neden olur.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	hamarat h, Yorulmaz G, Ekim A, Gönüllü E, Musmul A, Gurcu S (2022). Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?. , 26 - 31. 10.4274/tod.galenos.2021.90582
Chicago	hamarat hatice,Yorulmaz Goknur,Ekim Ayşe,Gönüllü Emel,Musmul Ahmet,Gurcu Sinem Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?. (2022): 26 - 31. 10.4274/tod.galenos.2021.90582
MLA	hamarat hatice,Yorulmaz Goknur,Ekim Ayşe,Gönüllü Emel,Musmul Ahmet,Gurcu Sinem Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?. , 2022, ss.26 - 31. 10.4274/tod.galenos.2021.90582
AMA	hamarat h,Yorulmaz G,Ekim A,Gönüllü E,Musmul A,Gurcu S Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?. . 2022; 26 - 31. 10.4274/tod.galenos.2021.90582
Vancouver	hamarat h,Yorulmaz G,Ekim A,Gönüllü E,Musmul A,Gurcu S Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?. . 2022; 26 - 31. 10.4274/tod.galenos.2021.90582
IEEE	hamarat h,Yorulmaz G,Ekim A,Gönüllü E,Musmul A,Gurcu S "Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?." , ss.26 - 31, 2022. 10.4274/tod.galenos.2021.90582
ISNAD	hamarat, hatice vd. "Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?". (2022), 26-31. https://doi.org/10.4274/tod.galenos.2021.90582

APA	hamarat h, Yorulmaz G, Ekim A, Gönüllü E, Musmul A, Gurcu S (2022). Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?. Türk Osteoporoz Dergisi, 28(1), 26 - 31. 10.4274/tod.galenos.2021.90582
Chicago	hamarat hatice,Yorulmaz Goknur,Ekim Ayşe,Gönüllü Emel,Musmul Ahmet,Gurcu Sinem Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?. Türk Osteoporoz Dergisi 28, no.1 (2022): 26 - 31. 10.4274/tod.galenos.2021.90582
MLA	hamarat hatice,Yorulmaz Goknur,Ekim Ayşe,Gönüllü Emel,Musmul Ahmet,Gurcu Sinem Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?. Türk Osteoporoz Dergisi, vol.28, no.1, 2022, ss.26 - 31. 10.4274/tod.galenos.2021.90582
AMA	hamarat h,Yorulmaz G,Ekim A,Gönüllü E,Musmul A,Gurcu S Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?. Türk Osteoporoz Dergisi. 2022; 28(1): 26 - 31. 10.4274/tod.galenos.2021.90582
Vancouver	hamarat h,Yorulmaz G,Ekim A,Gönüllü E,Musmul A,Gurcu S Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?. Türk Osteoporoz Dergisi. 2022; 28(1): 26 - 31. 10.4274/tod.galenos.2021.90582
IEEE	hamarat h,Yorulmaz G,Ekim A,Gönüllü E,Musmul A,Gurcu S "Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?." Türk Osteoporoz Dergisi, 28, ss.26 - 31, 2022. 10.4274/tod.galenos.2021.90582
ISNAD	hamarat, hatice vd. "Do Vitamin D Levels Affect Bone Mineral Density in Reproductive Women with Low Ferritin Levels?". Türk Osteoporoz Dergisi 28/1 (2022), 26-31. https://doi.org/10.4274/tod.galenos.2021.90582