Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients

Arslan, Burak; Bilici Salman, Reyhan; Babaoglu, Hakan; Atas, Nuh; Avanoglu Guler, Aslihan; KARADENİZ, HAZAN; Goker, Berna; öztürk, mehmet akif; TUFAN, ABDURRAHMAN; Satış, Hasan; HAZNEDAROGLU, SEMINUR; Güven, Serdar Can

doi:10.4274/raed.galenos.2023.92486

Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients

Hasan SATIŞ, (Gazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Reyhan BİLİCİ SALMAN, (Gazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Hakan BABAOĞLU, (Gazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Nuh ATAŞ, (Gazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Aslıhan AVANOĞLU GÜLER, (Gazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Hazan KARADENİZ, (Gazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Berna GÖKER, (Gazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Seminur HAZNEDAROĞLU, (Gazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Mehmet Akif ÖZTÜRK, (Gazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Abdurrahman TUFAN, (Gazi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Burak ARSLAN, (Gazi University, Faculty of Medicine, Department of Biochemistry, Ankara, Turkey)

Serdar Can GÜVEN, (Gazi University, Physical Therapy and Rehebilitation, Department of Rheumatology, Ankara, Turkey)

Diğer Yazarlar

Ulusal Romatoloji Dergisi

27 6

Yıl: 2023 Cilt: 15 Sayı: 1 Sayfa Aralığı: 1 - 5 Metin Dili: İngilizce DOI: 10.4274/raed.galenos.2023.92486 İndeks Tarihi: 31-05-2023

Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients

Öz:

Objective: Gastrointestinal problems are frequently encountered in systemic sclerosis (SSc) and primary Sjogren’s syndrome (pSS). It has been thought that the pancreas were affected by these diseases. It was aimed to investigate exocrine pancreatic insufficiency in SSc and pSS patients and its potential effect on patient’s gastrointestinal problems. Methods: Patients with a diagnosis of SSc or pSS patients, according to 2013 and 2016 American College of Rheumatology/European League Against Rheumatism criteria were consecutively examined. The gastrointestinal quality of life questionnaire was used for functional assessment. Fecal samples were taken from participants and fecal elastase level (fe), which were measured by the ELISA kit. Results: Forty SSc and forty-one pSS patients were enrolled in the study. Groups had similar disease duration, age, and sex distribution. Fe levels were not different between the groups, Healthy control groups had median fe level of 516 μg/g, whereas SSc patients had 437±128 μg/g and pSS patients had 428±149 μg/g. The proportion of patients exhibiting pathological fecal elastase levels were also the same between the groups (12.2% versus 7.5% respectively). However, the functional survey score was worse in the SSc group. Conclusion: Gastrointestinal problems were prevalent in connective tissue disorders, especially in SSc patients. Although pancreatic exocrine dysfunction is rare in these patient groups, its contribution to the development of these complaints is limited.

Anahtar Kelime:

Sistemik skleroz ve primer Sjögren sendromu hastalarında ekzokrin pankreas disfonksiyonu

Öz:

Amaç: Skleroderma (SSc) ve primer Sjögren sendromunda (pSS) gastrointestinal problemlerle sıklıkla karşılaşılır. Pankreasın bu hastalıklardan etkilendiği düşünülmektedir. Bu çalışmada, SSc ve pSS hastalarında ekzokrin pankreas yetmezliğinin ve hastanın gastrointestinal problemlerine olası etkisinin araştırılması amaçlandı. Yöntem: 2013 ve 2016 Amerikan Romatoloji Birliği/Avrupa Romatoloji Birliği kriterlerine göre SSc veya pSS hastası tanısı alan hastalar incelendi. Fonksiyonel değerlendirme için gastrointestinal yaşam kalitesi anketi kullanıldı. Katılımcılardan dışkı örnekleri alındı ve ELISA kiti ile ölçülen dışkı elastaz düzeyi (fe) bakıldı. Bulgular: Çalışmaya kırk SSc ve kırk bir pSS hastası alındı. Gruplar benzer hastalık süresine, yaş ve cinsiyet dağılımına sahipti. Fe düzeyleri gruplar arasında farklı değildi, SSc hastaları 437±128 μg/g ve pSS hastaları 428±149 μg/g idi. Patolojik fekal elastaz seviyeleri sergileyen hastaların oranı da gruplar arasında aynıydı (sırasıyla %12,2’ye karşı %7,5). Ancak, fonksiyonel anket puanları SSc grubunda daha kötüydü Sonuç: Gastrointestinal problemler, SSc hastalarında daha çok olmak üzere, bağ dokusu romatizması olan bireylerde yaygın olarak görülmektedir. Pankreatik ekzokrin disfonksiyonu bu hasta gruplarında nadir görülmekle beraber, bu şikayetlerin gelişmesine katkısı sınırldır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Satış H, Bilici Salman R, Babaoglu H, Atas N, Avanoglu Guler A, KARADENİZ H, Goker B, HAZNEDAROGLU S, öztürk m, TUFAN A, Arslan B, Güven S (2023). Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients. , 1 - 5. 10.4274/raed.galenos.2023.92486
Chicago	Satış Hasan,Bilici Salman Reyhan,Babaoglu Hakan,Atas Nuh,Avanoglu Guler Aslihan,KARADENİZ HAZAN,Goker Berna,HAZNEDAROGLU SEMINUR,öztürk mehmet akif,TUFAN ABDURRAHMAN,Arslan Burak,Güven Serdar Can Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients. (2023): 1 - 5. 10.4274/raed.galenos.2023.92486
MLA	Satış Hasan,Bilici Salman Reyhan,Babaoglu Hakan,Atas Nuh,Avanoglu Guler Aslihan,KARADENİZ HAZAN,Goker Berna,HAZNEDAROGLU SEMINUR,öztürk mehmet akif,TUFAN ABDURRAHMAN,Arslan Burak,Güven Serdar Can Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients. , 2023, ss.1 - 5. 10.4274/raed.galenos.2023.92486
AMA	Satış H,Bilici Salman R,Babaoglu H,Atas N,Avanoglu Guler A,KARADENİZ H,Goker B,HAZNEDAROGLU S,öztürk m,TUFAN A,Arslan B,Güven S Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients. . 2023; 1 - 5. 10.4274/raed.galenos.2023.92486
Vancouver	Satış H,Bilici Salman R,Babaoglu H,Atas N,Avanoglu Guler A,KARADENİZ H,Goker B,HAZNEDAROGLU S,öztürk m,TUFAN A,Arslan B,Güven S Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients. . 2023; 1 - 5. 10.4274/raed.galenos.2023.92486
IEEE	Satış H,Bilici Salman R,Babaoglu H,Atas N,Avanoglu Guler A,KARADENİZ H,Goker B,HAZNEDAROGLU S,öztürk m,TUFAN A,Arslan B,Güven S "Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients." , ss.1 - 5, 2023. 10.4274/raed.galenos.2023.92486
ISNAD	Satış, Hasan vd. "Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients". (2023), 1-5. https://doi.org/10.4274/raed.galenos.2023.92486

APA	Satış H, Bilici Salman R, Babaoglu H, Atas N, Avanoglu Guler A, KARADENİZ H, Goker B, HAZNEDAROGLU S, öztürk m, TUFAN A, Arslan B, Güven S (2023). Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients. Ulusal Romatoloji Dergisi, 15(1), 1 - 5. 10.4274/raed.galenos.2023.92486
Chicago	Satış Hasan,Bilici Salman Reyhan,Babaoglu Hakan,Atas Nuh,Avanoglu Guler Aslihan,KARADENİZ HAZAN,Goker Berna,HAZNEDAROGLU SEMINUR,öztürk mehmet akif,TUFAN ABDURRAHMAN,Arslan Burak,Güven Serdar Can Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients. Ulusal Romatoloji Dergisi 15, no.1 (2023): 1 - 5. 10.4274/raed.galenos.2023.92486
MLA	Satış Hasan,Bilici Salman Reyhan,Babaoglu Hakan,Atas Nuh,Avanoglu Guler Aslihan,KARADENİZ HAZAN,Goker Berna,HAZNEDAROGLU SEMINUR,öztürk mehmet akif,TUFAN ABDURRAHMAN,Arslan Burak,Güven Serdar Can Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients. Ulusal Romatoloji Dergisi, vol.15, no.1, 2023, ss.1 - 5. 10.4274/raed.galenos.2023.92486
AMA	Satış H,Bilici Salman R,Babaoglu H,Atas N,Avanoglu Guler A,KARADENİZ H,Goker B,HAZNEDAROGLU S,öztürk m,TUFAN A,Arslan B,Güven S Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients. Ulusal Romatoloji Dergisi. 2023; 15(1): 1 - 5. 10.4274/raed.galenos.2023.92486
Vancouver	Satış H,Bilici Salman R,Babaoglu H,Atas N,Avanoglu Guler A,KARADENİZ H,Goker B,HAZNEDAROGLU S,öztürk m,TUFAN A,Arslan B,Güven S Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients. Ulusal Romatoloji Dergisi. 2023; 15(1): 1 - 5. 10.4274/raed.galenos.2023.92486
IEEE	Satış H,Bilici Salman R,Babaoglu H,Atas N,Avanoglu Guler A,KARADENİZ H,Goker B,HAZNEDAROGLU S,öztürk m,TUFAN A,Arslan B,Güven S "Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients." Ulusal Romatoloji Dergisi, 15, ss.1 - 5, 2023. 10.4274/raed.galenos.2023.92486
ISNAD	Satış, Hasan vd. "Exocrine pancreatic dysfunction in systemic sclerosis and primary Sjogren’s syndrome patients". Ulusal Romatoloji Dergisi 15/1 (2023), 1-5. https://doi.org/10.4274/raed.galenos.2023.92486